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CURRICULUM VITAE
Hsi-Hsun Lin, M.D.
Male
April 16, 1959
1, E-Da Road, Yan-chau Shiang,
Kaohsiung County, Taiwan, 824
886-7-6150011 ext5550
[email protected]
1977-1984 M.D., National Defense Medical Center,
Taipei, Taiwan, R.O.C.
1985-1990 Resident in Department of Medicine,
Naval General Hospital, Kaohsiung
1987-1989
Chief Resident, Section of Infectious Diseases,
Veterans General Hospital, Taipei
1990-1995
Attending physician, Section of Infectious Diseases
Naval General Hospital, Kaohsiung
1995-1997
Chief Resident, Section of infectious Diseases,
Kaohsiung Veterans General Hospital, Kaohsiung
1998-1999
Research fellowship in Aaron Diamond AIDS
Research Center, The Rockefeller University,
New York, N.Y
1997-2004
Attending physician, Section of Infectious Diseases,
Kaohsiung Veterans General Hospital, Kaohsiung
2004-2007
Assistant professor, I-Shou University
2007- 2009
Adjunct assistant researcher, division of clinical
research, National Health Research Institude,
Taiwan
2007- present Chief, Section of Infectious Diseases, E-Da Hospital
2007-present Associate professor, I-Shou University
2009-present Associate Director, Department of Internal Medicien,
E-Da Hospital, Taiwan
8. Publication in Journals (recent 5 years): (*correspondence)
1. Lin JN, Lai CH, Chen YH, Chang LL, Lu PL, Lin HL, Huang CK, Lin HH*. Characteristics
and outcomes of polymicrobial bloodstream infection in the emergency department: A
matched case-control study. Acad Emerg Med. 2010 Oct;17(10):1072-1079.
2. Ko NY, Yen CF, Chen CH, Lee HC, Ko WC, Lin HH, Hsu ST. Applying the transtheoretical
model to the readiness to change blood-borne virus transmission behaviors among drugdependent inmates. Am J Addict. 2010 Sep;19(5):433-9.
3. Lee SS, Chou KJ, Dou HY, Huang TS, Ni YY, Fang HC, Tsai HC, Sy CL, Chen JK, Wu KS,
Wang YH, Lin HH, Chen YS*. High prevalence of latent tuberculosis infection in dialysis
patients using the interferon-γ release assay and tuberculin skin test. Clin J Am Soc Nephrol.
2010 Aug;5(8):1451-7.
4. Lai CH, Lin JN, Chang LL, Chen YH, Lin HH*. Circulating cytokines and procalcitonin in
acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course
steroid therapy: a case report. BMC Infect Dis. 2010 Jul 1;10(1):193.
5. Liang SH, Chen TJ, Lee SS, Tseng FC, Huang CK, Lai CH, Chiou CP, Wang JL, Chung HC,
Lin JN, Kuo YC, Lin HH*. Risk factors of isolated antibody against core antigen of hepatitis
B virus: Association with HIV infection and age, but not hepatitis C virus infection. J Acquir
Immune Defic Syndr. 2010 Jun 1;54(2):122-128.
6. Chien ST, Hsueh JC, Lin HH, Shih HY, Lee TM, Ben RJ, Chou ST, Fone CM, Lin YE*,
Tseng LR, Chiang CS. Epidemiological investigation of a case of nosocomial Legionnaires’
disease in Taiwan: implications for routine environmental surveillance. Clin Microbiol Infect.
2010 Jun:16(6):761-3.
7. Chen YS#, Lin HH#, Mu JJ, Chiang CS, Chen CH, Buu LM, Lin YE, Chen YL*.
Distribution of melioidosis cases and viable Burkholderia pseudomallei in soil: Evidence for
emerging melioidosis in Taiwan. J Clin Microbiol. 2010 Apr;48(4): 1432-4. (# equal
contribution)
8. Huang CK, Huang TS, Lin HH, Lee SS, Liu YC*. Comparison of the AMPLICOR
MYCOBACTERIUM Test with Microscopy and Culture for Diagnosis of Pulmonary
Tuberculosis. J Intern Med Taiwan. 2010 Apr;21(2):117-124.
9. Lin JN, Lai CH, Chen YH, Lin HL, Huang CK, Chen WF, Wang JL, Chung HC, Liang SH,
Lin HH*. Sphingomonas paucimobilis bacteremia in humans: 16 cases reports and a
literature review. J Microbiol Immunol Infect. 2010 Feb;43(1):35-42.
10. Lin JN, Lin HH, Lai CH, Wang JL, Yu TJ. Renal transplant recipient infected with
Penicillium marneffei. Lancet Infect Dis. 2010 Feb;10(2):138.
11. Liu YC, Lin HH, Chen YS, Su IJ, Huang TS, Tsai HC, Wann SR, Lee SS*. Reduced health
provider delay and mortality of tuberculosis due to improved TB service program at a hospital.
Int J Tuberc Lung Dis. 2010 Jan;14(1):72-8.
12. Lin JN, Lin HL, Huang CK, Lai CH, Chung HC, Liang SH, Lin HH*. Endometriosis
presenting as bloody ascites and shock. J Emerg Med. 2010 Jan;38(1):30-2.
13. Lai CH, Chen YH, Lin JN, Chang LL, Chen WF, Lin HH*. Acute Q fever and scrub typhus
coinfection, southern Taiwan. Emerg Infect Dis. 2009 Oct;15(10):1659-61.
14. Lin JN, Lai CH, Chen YH, Huang CK, Wang JL, Chung HC, Liang SH, Lin HH*. Gasforming liver abscess caused by Klebsiella pneumonia. BMJ Case Reports. 2009;
doi:10.1136/bcr.08.2008.0638.
15. Lin JN, Lai CH, Chen YH, Huang CK, Lin HF, Eng HL, Lin HH*. Urinary Mycobacterium
szulgai infection in an immunocompetent patient. South Med J. 2009 Sep;102(9):979-81.
16. Lin JN, Tsai YS, Lai CH, Chen YH, Tsai SS, Lin HL, Huang CK, Lin HH*. Risk factors for
mortality of bacteremic patients in the emergency department. Acad Emerg Med. 2009
Aug;16(8):749-55.
17. Lai CH, Huang CK, Chen YH, Chang LL, Weng HC, Lin JN, Chung HC, Liang SH, Lin
HH*. Epidemiology of acute Q fever, scrub typhus, and murine typhus, and identification of
their clinical characteristics compared to patients with acute febrile illness in southern Taiwan.
J Formos Med Assoc. 2009 May;108(5):367-76.
18. Lin JN, Lai CH, Chen YH, Lee SSJ, Tsai SS, Huang CK, Chung HC, Liang SH, Lin HH*.
Risk factors for extra-pulmonary tuberculosis comparative to pulmonary tuberculosis. Int J
Tuberc Lung Dis. 2009 May;13(5):620-5. (SCI, IF 2.548, 15/43=34.9%, Respiratory system)
19. Lai CH, Huang CK, Weng HC, Chung HC, Liang SH, Lin, JN, Lin CW, Hsu CY, Lin HH*.
The difference in clinical characteristics between acute Q fever and scrub typhus in southern
Taiwan. Int J Infect Dis. 2009 May;13(3):387-93.
20. Lin JN, Lai CH, Huang CK, Chung HC, Liang SH, Lin HH*. Salmonella infection after
surgery of small intestine foreign bodies. Med Princ Pract. 2009;18(3):242-4.
21. Lee SS, Chou KJ, Su IJ, Chen YS, Fang HC, Hung TS, Tsai HC, Wann SR, Lin HH, Liu
YC*. High prevalence of latent tuberculosis infection in patients in end-stage renal disease on
hemodialysis: comparison of QuantiFERON-TB GOLD, ELISPOT and tuberculin skin test.
Infection. 2009 Apr;37(2):96-102.
22. Lin JN, Huang CK, Lai CH, Chung HC, Liang SH, Lin HH*, Lin HL. Reply to letter entitled
"Comparing Bromism with methyl bromide toxicity". Clin Toxicol (Phila). 2009
Apr;47(4):372.
23. Chen YS, Lin HH, Wu CH, Hsiao YS, Hsu NS, Chen YL*. Colonization of a medical center
in southern Taiwan by epidemic strains of carbapenem- and
multidrug-resistant Acinetobacter baumannii and the genetic organization of their integrons.
Jpn J Infect Dis. 2009 Mar;62(2):155-7.
24. Chen YS, Lin HH, Hung CC, Mu JJ, Hsiao YS, Chen YL*. Phenotypic characteristics and
pathogenic ability across distinct morphotypes of Burkholderia pseudomallei DT. Microbiol
Immunol. 2009 Mar;53(3):184-9.
25. Lin JN, Lin HL, Huang CK, Lai CH, Chung HC, Liang SH, Lin HH*. Myoclonic jerks due to
acute bromovalerylurea intoxication. Clin Toxicol (Phila). 2008 Nov; 46(9):861-3.
26. Lai CH, Huang CK, Weng HC, Chung HC, Liang SH, Lin, JN, Lin CW, Hsu CY, Lin HH*.
Clinical characteristics of acute Q fever, scrub typhus, and murine typhus with delayed
defervescence despite doxycycline treatment. Am J Trop Med Hyg. 2008 Sep; 79(3):441-446.
27. Chung HC, Lee CT, Lai CH, Huang CK, Lin JN, Liang SH, Lin HH*. Non-septicemic
melioidosis presenting as cardiac tamponade. Am J Trop Med Hyg. 2008 Sep;79(3): 455-457.
28. Lee SS, Chen YS, Tsai HC, Wann SR, Lin HH, Huang CK, Liu YC*. Predictors of Septic
Metastatic Infections and Mortality in Patients with Klebsiella pneumoniae Liver Abscess.
Clin Infect Dis. 2008 Sep 1, 47(5): 642-650.
29. Yu PY, Lin YE, Lin WR, Shih HY, Chuang YC, Ben RJ, Huang WK, Chen YS, Liu YC,
Chang FY, Yen MY, Liu CC, Ko WC, Lin HH, Shi ZY. The high prevalence of Legionella
pneumophila contamination in hospital potable water systems in Taiwan: implications for
hospital infection control in Asia. Int J Infect Dis. 2008 Jul; 12(4): 416-20.
30. Liu JY, Lin HH*, Liu YC, Lee SS, Chen YL, Hung CC, Ko WC, Huang CK, Lai CH, Chen
YS, Shih YL, Chung HC, Liang SH, Lin JN. Extremely high prevalence and genetic diversity
of hepatitis C virus infection among HIV-1 infected injection drug users in Taiwan. Clin
Infect Dis. 2008 Jun 1; 46(11):1761-1768.
31. Liang SH, Lo YC, Lin HH, Chang SY, Chen MY, Hsieh SM, Sheng WH, Sun HY, Hung
CC*, Chang SC. Seroprevalence of viral hepatitis and infectious complications among human
immunodeficiency virus-infected injection drug users at a referral hospital. J Microbiol
Immunol Infect. 2008 Jun;41(3):200-8.
32. Lin HH, Lin JN. Tender nodules on the palms and soles after chemotherapy. Can Med Assoc
J. 2008 Jun 3;178(12):1543-4.
33. Lee SS, Liu YC*, Huang TS, Chen YS, Tsai HC, Wann SR, Lin HH. Comparison of the
interferon- gamma release assay and the tuberculin skin test for contact investigation of
tuberculosis in BCG-vaccinated health care workers. Scand J Infect Dis. 2008 Apr; 40(5):37380.
34. Tsai WL, Lo GH, Hsu PI, Lai KH, Lin CK, Chan HH, Chen WC, Cheng JS, Liu YC, Huang
TS, Ger LP, Lin HH. Role of genotype and precore/basal core promoter mutations of hepatitis
B virus in patients with chronic hepatitis B with acute exacerbation. Scand J Gastroenterol.
2008 Feb;43(2):196-201.
35. Lai CH, Huang CK, Chin C, Chung HC, Huang WS, Lin CW, Hsu CY, Lin HH*. Acute Q
fever: An emerging and endemic disease in southern Taiwan. Scand J Infect Dis. 2008
Jan;40(2):105-110. 36. Lai CH, Huang CK, Chin C, Chen WF, Yang YT, Chen YL, Lin HH*.
Acute septicemic melioidosis presenting with acute cholangitis. Infection. 2007 Dec;
35(6):461-4.
37. Lai CH, Chin C, Huang CK, Chen WF, Yang YT, Chen W, Lin HH*. Acute Q fever hepatitis
in patients with and without underlying hepatitis B or C virus infection. Clin Infect Dis. 2007
Sep 1;45(5):e52-9.
38. Su HP, Yang HW, Chen YL*, Ferng TL, Chou YL, Chung TC, Chen CH, Chiang CS, Kuan
MM, Lin HH, Chen YS. Prevalence of melioidosis in the Er-Ren River Basin, Taiwan:
implications for transmission. J Clin Microbiol. 2007 Aug;45(8):2599-2603.
39. Lin HH, Huang SP, Hsieh HC, Chen CS, Chen YL*. Performance characteristics of the
limulus amebocyte lysate assay and Gas Chromatography-Mass Spectrum analysis of
liposaccharides relative to Nitric Oxide production by peritoneal exudates of cells. J Hazard
Mater. 2007 Jul 16;145(3):431-6.
40. Lai CH, Yen CM, Chin C, Chung HC, Kuo HC, Lin HH*. Eosinophilic meningitis caused by
Angiostrongylus cantonensis after ingestion of raw frogs. Am J Trop Med Hyg. 2007 Feb;
76(2):399-402.
41. Lai CH, Chin C, Chung HC, Liu H, Hwang JC, Lin HH*. Clonorchiasis associated perforated
eosinophilic cholecystitis. Am J Trop Med Hyg. 2007 Feb; 76(2):396-398.
42. Lai CH, Huang CK, Chin C, Yang YT, Lin HF, Lin HH*. Indigenous case of disseminated
histoplasmosis, Taiwan. Emerg Infect Dis. 2007 Jan;13(1): 127-129.
43. Chen YL, Chen YS, Lin HH, Chan CW, Chen SC, Chen CH*. Immunostimulatory Flagellin
from Burkholderia pseudomallei Effects on an Increase in the Intracellular Calcium
Concentration and Up-Regulation of TNF-alpha by Mononuclear Cells. Microbiol Immunol.
2007 Jan;51(1):81-6.
44. Lin HH, Huang SP, Teng HC, Ji DD, Chen YS, Chen YL*. Presence of the exoU gene of
Pseudomonas aeruginosa is correlated with cytotoxicity in MDCK cells but not with
colonization in BALB/c mice. J Clin Microbiol. 2006 Dec;44(12):4596-4597.
45. Lai CH, Wong WW, Chin C, Huang CK, Lin HH*, Chen WF, Yu KW, Liu CY. Central
venous catheter-related Stenotrophomonas maltophilia bacteremia and associated relapsing
bacteremia in hematology and oncology patients. Clin Microbiol Infect. 2006 Oct;12(10):986991.
46. Tang HJ, Liu YC *, Yen MY, Chen YS, Wann SR, Lin HH, Lee SS, Lin WR, Huang CK, Su
BA, Chang PC, Li CM, Tseng HH. Opportunistic infections in adults with acquired
immunodeficiency syndrome: a comparison of clinical and autopsy findings. J Microbiol
Immunol Infect. 2006 Aug;39(4):310-315.
47. Lai CH, Lin HH*. Cases of Histoplasmosis Reported in Taiwan. J Formos Med Assoc. 2006
July;105(7):527-528.
48. Lin HH*, Shih YL, Liu YC, Lee SS, Huang CK, Chen YL, Chin C, Lai CH, Tsai HC, Guo
YC, Zhang L. An Epidemic of HIV Type 1 CRF07_BC Infection among Injection Drug Users
in Taiwan. J Acquir Immune Defic Syndr. 2006 Jun;42(2):248-255.
49. Lin HH, Gaschen BK, Collie M, EL-Fishaway M, Chen Z, Korber BT, Beatrice ST, Zhang
L*. Genetic Characterization of Diverse HIV-1 Strains in an Immigrant Population Living in
New York City. J Acquir Immune Defic Syndr. 2006 Apr;41(4):399-404.
50. Chen YS, Hsiao YS, Lin HH, Liu Y, Chen YL*. CpG modified plasmid DNA encoding
flagellin improves immunogenicity and protection against Burkholderia pseudomallei infection
in Balb/c mice. Infect Immune. 2006 Mar;74(3):1699-1705.
51. Chen YS, Hsiao YS, Lin HH,Yen CM, Chen SC, Chen YL*. Immunogenicity and antiBurkholderia pseudomallei activity in Balb/c mice immunized with plasmid DNA encoding
flagellin. Vaccine. 2006 Feb;24(6):750-758.
52. Lai CH, Huang CK, Chin C, Lin HH*, Chi CY, Chen HP. Acute acalculous cholecystitis: a
rare presentation of typhoid fever in adults. Scand J Infect Dis. 2006 Mar;38(3):196-200.
53. Chin C, Chen YS, Lee SS, Wann SR, Lin HH, Lin WR, Huang CK, Tsai HC, Kao CH, Yen
MY, Liu YC*. Fever of Unknown Origin in Taiwan. Infection. 2006 Apr; 34(2):75-80.
54. Lai CH, Hwang CK, Chin C, Lin HH*, Wong WW, Liu CY. Severe watery diarrhoea and
bacteraemia caused by Vibrio fluvialis. J Infect. 2006 Mar;52(3): e95-8.