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CURRICULUM VITAE
BAREND JACOBUS (BEN) MARAIS
NATIONALITIES:
AUSTRALIAN & SOUTH AFRICAN
DATE OF BIRTH:
28 FEBRUARY 1970
MARRIED:
KAREN EDITH MARAIS (nee FRIEMELT)
CHILDREN:
RICHARD CARL MARAIS (29/03/2000)
JACOBUS MARTHINUS MARAIS (29/05/2002)
EMPLOYMENT RECORD
Current Appointment
From 01/06/2011
Prior appointments
01/02/11-31/05/2011
- Associate Professor, University of Sydney, Australia; DeputyDirector, Marie Bashir Institute for Infectious Diseases and
Biosecurity (www.sydney.edu.au/mbi)
- Senior Clinical Academic and Infectious Diseases specialist;
The Children’s Hospital at Westmead
- External Professor, Paediatrics and Child Health, Health
Sciences Faculty, Stellenbosch University, South Africa
Academic fellow, Clinical School, The Children’s Hospital at
Westmead, Australia
01/03/10–31/01/2011
Professor – Department of Paediatrics and Child Health, Health
Sciences Faculty, Stellenbosch University, South Africa
Principal consultant paediatrician (Infectious Diseases),
Tygerberg hospital, South Africa
01/01/09-28/02/2010
Associate Professor – Department of Paediatrics and Child
Health, Stellenbosch University, South Africa
Principal consultant paediatrician, Tygerberg hospital
01/01/07-31/12/2008
Acting Director, Ukwanda Centre for Rural Health &
Associate Professor – Department of Paediatrics and Child
Health, Stellenbosch University, South Africa
Senior consultant paediatrician, Tygerberg hospital
01/01/06-31/12/2006
Research Director, Ukwanda Centre for Rural Health,
Stellenbosch University, South Africa
Associate Professor – Child TB research coordinator, Desmond
Tutu TB Centre, Stellenbosch University, SA
Consultant paediatrician, Tygerberg and Karl Bremer hospitals
01/01/03-31/12/2005
PhD student, Desmond Tutu TB Centre, University of
Stellenbosch, South Africa
Consultant paediatrician at Tygerberg and Karl Bremer hospitals
Health 24 - on-line Paediatric Expert
01/07/01-31/12/2002
Senior Registrar Paediatrics, Stellenbosch University,
Tygerberg Children’s Hospital, South Africa
01/01/01-30/06/2001
Exchange Registrar Paediatrics, Utrecht University,
Wilhelmina Children’s Hospital, Netherlands
01/07/98-31/12/2000
Registrar Paediatrics, Stellenbosch University,
Tygerberg Children’s Hospital, South Africa
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01/01/98-31/05/1998
General Practitioner
Kindersley, Saskatchewan, Canada
06/07/96-08/08/1997
Senior SHO Paediatrics and Neonatology
St. Mary’s Hospital, Isle of Wight, UK
04/02/96-05/07/1996
SHO Paediatrics
St. Mary’s Hospital, Isle of Wight, UK
01/01/95-31/12/1995
Internship
George Provincial Hospital, South Africa
Sabbatical
01/08/08-31/12/08
NIH Pediatric Infectious Diseases Training fellowship, Denver
Children’s Hospital, Colorado, USA
ACADEMIC QUALIFICATIONS
FRACP (Paed)
Royal Australian College of Physicians (F12845) - 2012
Post-grad Dipl Infect Dis
London School of Hygiene and Tropical Medicine - 2010
PhD
University of Stellenbosch, South Africa - 2006
MMed (Paed)
University of Stellenbosch, South Africa - 2002
FCP (Paed)
College of Medicine of South Africa - 2000
MRCP (Paed)
Royal College of Physicians United Kingdom (Edinburgh) - 1997
MBChB
University of Stellenbosch, South Africa - 1994
BMedSc
University of Stellenbosch, South Africa - 1991
PUBLICATION RECORD
Review articles in peer reviewed journals
Graham SM, Cuevas LE, Jean-Philippe P, Casenghi M, Browning R, Detjen AK,
Gnanashanmugam D, Kampmann B, Mandalakas A, Marais BJ, Schito M, Spiegel H, Starke
JR, Worrell C, Hesseling AC, Zar HJ. Clinical Case Definitions for Classification of
Intrathoracic Tuberculosis in Children: An Update. Clin Infect Dis 2015; In Press
Grobler LA, Mabunda S, Marais BJ. Interventions for increasing the proportion of health
professionals practising in rural and other underserved areas. Cochrane Database Syst Rev.
2015. In Press
Nachman S, Ahmed A, Amanullah F, Becerra MC, Botgros R, Brigden G, Browning R,
Gardiner E, Hafner R, Hesseling A, How C, Jean-Philippe P, Lessem E, Makhene M, Mbelle
N, Marais B, McIlleron H, Mc Neeley D, Mendel C, Murray S, Navarro E, Oramasionwu GE,
Porcalla AR, Powell C, Powell M, Rigaud M, Rouzier V, Samson P, Schaaf HS, Shah S,
Starke J, Swaminathan S, Wobudeya E, Worrell C. Towards earlier inclusion of Children in
Tuberculosis drugs trials: Consensus statements from an Expert Panel. Lancet Infect Dis
2015; 15: 711-20
Oliwa J, Karumbi J, Marais BJ, Madhi SA, Graham S. Tuberculosis as a cause or comorbidity
of childhood pneumonia in tuberculosis-endemic countries: a systematic review. Lancet Resp
Med 2015; 3: 235-43
Trinh MQ, Nguyen HL, Nguyen VN, Nguyen VA, Sintchenko V, Marais BJ. Tuberculosis and
HIV co-infection – focus on the Asia-Pacific region. Int J Infect Dis 2015; 32: 170-8
Islam T, Marais BJ, Nhung NV, Chiang C-Y, Yew WW, Yoshiyama T, Mira NR, van den Broek
J, Lumb R, Nishikiori Nobuyuki, Reichman L. Western Pacific Regional Green Light
Committee: progress and way forward. Int J Infect Dis 2015; 32: 161-5
von Delft A, Dramowski A, Khosa C, Kotze K, Lederer P, Mosidi T, Peters JA, Smith J, van
der Westhuizen H, von Delft D, Willems B, Bates M, Craig G, Maeurer M, Marais BJ, Mwaba
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P, Nunes E, Nyirenda T, Oliver M, Zumla A. Why Healthcare Workers are Sick of
Tuberculosis. Int J Infect Dis 2015; 32: 147-51
Brigden G, Furin J, van Gulik C, Marais B. Getting it right for children: improving TB treatment
access and new treatment options. Expert Review of Anti-infective Therapy 2015; 13: 451-61
Bates M, Marais BJ, Zumla A. Tuberculosis Comorbidity with Communicable and
Noncommunicable Diseases. Cold Spring Harb Perspect Med 2015; Feb 6. pii: a017889. doi:
10.1101/cshperspect.a017889
Marais BJ, Schaaf HS. Tuberculosis in Children. Cold Spring Harb Perspect Med 2014; Jul 18
4(9): a017855. doi: 10.1101/cshperspect.a017855
Bissell K,Viney K, Brostrom R, Gounder S, Graham S, Hill P, Khogali M, Kishore K, Kool B,
Kumar AMV, Manzi M, Marais B, Marks G, Nguyen L, Ram S, Reid S, Roseveare C, TaylerSmith K, van den Bergh R, Harries AD. Operational Research Capacity Building in the Pacific.
Public Health Action 2014; 4 Suppl 1: S2-13
Harries AD, Marais B, Kool B, Ram S, Kumar AMV, Gounder S, Viney K, Brostrom R,
Roseveare C, Bissell K, Reid T, Zachariah R, Hill PC. Mentorship for operational research
capacity building: hands-on or hands-off? Public Health Action 2014; 4 Suppl 1: S56-58
Marais BJ. Tuberculosis in children. J Paed Child Health 2014; 50; 759-67
Siberry GK, Abzug MJ, Nachman S, Brady MT, Dominguez KL, Handelsman E, Mofenson
LM, Nesheim S; and the Panel on Opportunistic Infections in HIV-Exposed and HIV-Infected
Children (Bhattacharya D; Bohannon B; Clarke D.; Edwards KM; Esbenshade JC; Flynn P;
Gaur A; Gigliotti F; Harrison G; Hobbs CV; Kimberlin D; Kleiman MB; Koumans EH; Kroger A;
Levin MJ; Mack CL; Marais BJ; Maron G; McAuley J; Menzies HJ; Moscicki A; Narkewicz MR;
Rutstein R; Seward J; Shimamura M; Steinbach WJ; Wilson GJ). Guidelines for the
Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected
Children: Recommendations from the National Institutes of Health, Centers for Disease
Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of
America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics.
Pediatr Infect Dis J 2013; 32 (Suppl 2): i-KK4. doi: 10.1097/01.inf.0000437856.09540.11.
Khatami A, Isaacs D, Marais B. Fever in the returned child traveller. Medicine Today 2013;
14: 27-38
Seddon J, Schaaf HS, Furin JF, Marais BJ, Tebruegge M, Detjen A, Hesseling AC, PerezVelez CM, Shah S, Adams L, Starke JR, Becerra MC, Swaminathan S. Consensus statement
on research definitions for drug-resistant tuberculosis in children. J Ped Infect Dis Soc 2013;
2:100-09
Abubakar I, Ford N, Cox H, Masham S, Lawn SD, Marais B, Mchugh T, McNerney R, Sarda
K, Mwaba P, Bates M, Migliori GB, Memish Z, Payam N, Logan S, Kim P, Hafner R, Cole S,
Maeurer M, Schito M, Zumla A. The rising tide of drug-resistant tuberculosis – time for
visionary leadership. Lancet Infect Dis 2013; 13: 529-39
Van den Driessche K, Persson A, Marais BJ, Fink PJ, Urdahl KB. Immune vulnerability of
infants to tuberculosis. Clin Developm Immunol 2013; 2013: 781320 (1-16)
http://dx.doi.org/10.1155/2013/781320
Ho J, Marais B, Ralph A, Gilbert G. Diagnosing Tuberculous Meningitis – Have We Made Any
Progress? Trop Med Int Health 2013: 18: 783-93
Marais B, Lönnroth K, Lawn S, Migliori GB, Mwaba P, Glaziou P, Colagiuri R, Bates M,
Zijenah L, Swaminathan S, Memish Z, Pletschette M, Hoelscher M, Abubakar I, Hasan R,
Zafar A, Pantaleo G, Craig G, Kim P, Maeurer M, Schito M, Zumla A. Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services
and control efforts. Lancet Infect Dis 2013; 13: 436-48
Britton P, Perez-Velez CM, Marais BJ. Diagnosis, treatment and prevention of tuberculosis in
children. NSW Public Health Bulletin 2013; 24: 15-21
Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, Marais BJ, Cuevas LE, Mchugh T,
Zinejah L, Hoelscher M, Memish Z, McNerney R, Migliori GB, Abubakar I, Hafner R, Kim P,
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Maeurer M, Schito M, Zumla A. Advances in diagnostic assays for tuberculosis: The Xpert
MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis 2013; 13: 34961
Perez-Velez CM, Marais BJ. Tuberculosis in children. N Engl J Med 2012: 367: 348-61
Al-Dabbagh M, van den Driessche K, Marais BJ, Kollmann TR. Management of multidrug
resistant tuberculosis in children. Eur Infect Dis 2012; 6: 35-40
Raviglione M, Marais B, Floyd K, Lönnroth K, Getahun H, Migliori GB, Harries AD, Nunn P,
Lienhardt C, Graham S, Chakaya J, Weyer K, Cole S, Kaufmann SHE, Zumla A. Scaling up
of interventions to achieve global tuberculosis control: progress, new developments and
update. Lancet 2012: 379: 1902-13
Zumla A, Abubakar I, Raviglione M, Ditiu L, Hoelscher M, Mchugh TD, Squire SB, Cox H,
Ford N, McNerney R, Marais B, Grobusch M, Lawn S, Migliori GB, Mwaba P, O’Grady J,
Pletschette M, Ramsay A, Chakaya J, Schito M, Swaminathan S, Memish Z, Maeurer M, Atun
R. Drug resistant TB – current dilemmas, unanswered questions, challenges and priority
needs. J Infect Dis 2012; 205: S228-40
McNerney R, Maeurer M, Weyer K, Marais B, Ford N, Casenghi M, Cox H, Lawn S, Memish
Z, Grobusch M, Squire B, Chakaya J, Mchugh T, Migliori GB, Mwaba P, Zinejah L,
Pletschette M, Swaminathan S, Kim P, Schito M. O’Grady J, Bates M, Schwanck S, Abubakar
I, Atun R, Zumla A. Tuberculosis Diagnostics and Biomarkers: needs, challenges, recent
advances and opportunities. J Infect Dis 2012; 205: S147-58
Cuevas LE, Ahmed T, Amanullah F, Browning R, Cardenas V, Casenghi M, Gale M, Graham
SM, Gie RP, Grzemska M, Handelsman E, Hatherill M, Hesseling AC, Jean-Philippe P,
Kampmann B, Kabra SK, Lienhardt C, Lighter-Fisher J, Madhi S, Makhene M, Marais BJ,
McNeeley DF, Menzies H, Mitchell C, Modi S, Mofenson L, Musoke P, Nachman S, Powell C,
Rigaud M, Rouzier V, Starke JR, Swaminathan S, Wingfield C. Evaluation of TB diagnostics
in children: Methodological issues for conducting and reporting research evaluations of TB
diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel. J Infect
Dis 2012; 205: S209-215
Graham SM, Ahmed T, Amanullah F, Browning R, Cardenas V, Casenghi M, Cuevas LE,
Gale M, Gie RP, Grzemska M, Handelsman E, Hatherill M, Hesseling AC, Jean-Philippe P,
Kampmann B, Kabra SK, Lienhardt C, Lighter-Fisher J, Madhi S, Makhene M, Marais BJ,
McNeeley DF, Menzies H, Mitchell C, Modi S, Mofenson L, Musoke P, Nachman S, Powell C,
Rigaud M, Rouzier V, Starke JR, Swaminathan S, Wingfield C. Evaluation of TB diagnostics
in children: Proposed clinical case definitions for classification of intrathoracic tuberculosis
disease. Consensus from an expert panel. J Infect Dis 2012; 205: 199-208
Seddon J, Hesseling AC, Marais BJ, Peloquin C, McIlleron H, Donald PR, Schaaf HS.
Paediatric use of second-line anti-tuberculosis agents: a review. Tuberculosis 2012; 92: 9-17
Obihara CC, Marais BJ, Detjen AK, van Furth AM. A brief overview of mycobacterial diseases
in children. Eur J Infect Dis 2011; 5: 102-11
Marais BJ, Schaaf HS, Donald PR. Management of tuberculosis in children and new
treatment options. Infect Disord Drug Targets 2011;11: 144-156
Marais BJ, Childhood tuberculosis: epidemiology and natural history of disease. Indian J Ped
2011; 78: 321-327
Marais BJ, Rabie H, Cotton MF. TB and HIV in children – advances in prevention and
management. Paediatr Respir Rev 2011; 12: 39-45
Al-Dabbagh M, Lapphra K, McGloin R, Inrig K, Schaaf HS, Marais BJ, Sauve L, Kitai I,
Kollmann TR. Drug-Resistant tuberculosis - Pediatric guidelines. Ped Infect Dis J 2011; 30:
501-5
Teasdale C, Marais BJ, Abrams EJ. HIV: prevention of mother-to-child transmission? BMJ Clin Evid
2011; Jan 17: 0909 www.clinicalevidence.bmj.com
Schaaf HS, Marais BJ. Management of multidrug-resistant tuberculosis in children: a survival
guide for paediatricians. Paediatr Respir Rev 2011; 12: 31-8
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Marais BJ, Raviglione M, Donald PR, Harries AD, Kritski AL, Graham SM, Atun R, El-Sadr W,
Churchyard G, Harrington M, Mwaba P, Sanne I, Kaufmann SE, Whitty CJM, Zumla A. Scaleup of services and research priorities for diagnosis, management and control of tuberculosis Call to action. Lancet 2010; 375: 2179-91
Marais BJ, Schaaf HS. Childhood Tuberculosis: an emerging and previously neglected
problem. Infect Dis Clin N Am 2010; 24: 727-49
Marais S, Pepper DJ, Marais BJ, Torok ME. HIV-associated tuberculous meningitis – diagnostic and
therapeutic challenges. Tuberculosis 2010; 90: 367-74
Marais S, Thwaites G, Schoeman J, Torok E, Misra UK, Prasad K, Donald PR, Wilkinson RJ,
Marais BJ. Tuberculosis Meningitis: defining a uniform case definition for use in clinical
research. Lancet Infect Dis 2010; 10: 803-12
Marais BJ, Ayles H, Graham SM, Godfrey-Faussett P. Screening and preventive therapy for
tuberculosis. Chest Clin N Am 2009; 30: 827-46
Hesseling AC, Caldwell J, Cotton MF, Eley BS, Jaspan HB, Jennings K, Marais BJ, Nuttall J,
Rabie H, Roux P, Schaaf HS. Western Cape paediatric HIV/TB advisory group consensus
statement on BCG vaccination in South African HIV-exposed infants. South Afr Med J 2009:
95: 598-600
Marais BJ, Schaaf HS, Donald PR. Pediatric tuberculosis: Issues related to current and future
treatment options. Future Microbiol 2009; 4: 661-75
Moore DP, Schaaf HS, Nuttall J, Marais BJ. Childhood tuberculosis guidelines of the
Southern African Society of Paediatric Infectious Diseases. South Afr J Epidemiol Infect
2009; 24: 57-68
Wilson NW, Couper I, de Vries E, Reid S, Fish T, Marais BJ. A critical review of interventions to redress
the inequitable distribution of medical professionals to rural and remote areas. Rural Remote Health 2009;
9:1060. Epub 2009 Jun 12
Marais BJ. Childhood intra-thoracic tuberculosis. Adv Exp Med Biol 2009; 634: 129-146
Wright CA, Warren RW, Marais BJ. Fine needle aspiration biopsy: an undervalued diagnostic modality in
pediatric mycobacterial disease. Int J Tuberc Lung Dis 2009; 13: 1467-75
Rowe JS, Shah SS, Marais BJ, Steenhoff AP. Diagnosis and Management of Tuberculous
Meningitis in HIV-Infected Pediatric Patients. Ped Infect Dis J 2009; 28: 147-8
Grobler LA, Marais BJ, Mabunda S, Marindi P, Reuter H, Volmink J. Interventions for
increasing the proportion of health professionals practising in rural and other underserved
areas. Cochrane Database Syst Rev. 2009 Jan 21; 1: CD005314
Marais BJ, Esser M, Godwin S, Rabie H, Cotton MF. Poverty and HIV in children a view from
the Western Cape, South Africa. Ann N Y Acad Sci. 2008; 1136: 21-7
Marais BJ. Tuberculosis in children. Ped Pulmonol 2008; 43: 322-9
Marais BJ, Volmink J. HIV:mother-to-child transmission. BMJ Clin Evid 2008; 1: 909
www.clinicalevidence.bmj.com
Rabie H, Marais BJ, van Toorn R, Nourse P, Nel ED, Goussard P, Sellers N, Cotton MF.
Important HIV-associated conditions in HIV–infected infants and children. SA Fam Pract
2007; 49: 19-23
Rabie H, Marais BJ, van Toorn R, Nel ED, Cotton MF. Common opportunistic infections in
HIV-infected children; Part 2 - non-respiratory infections. SA Fam Pract 2007; 49: 40-5
Marais BJ. Childhood Tuberculosis – Risk assessment and diagnosis. S Afr Med J 2007; 97:
978-82
Marais BJ, Cotton M, Graham S, Beyers N. Diagnosis and management challenges of
childhood TB in the era of HIV. J Infect Dis 2007; 196 (Suppl 1): S76-S85
Marais BJ. Adult-type TB in children. Salud i Ciencia (Expertos Invitados) 2007; 15: 977-82
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Marais BJ, Pai M. New Approaches and emerging technologies in the diagnosis of childhood
tuberculosis. Paediatr Respir Rev 2007; 8: 124-33
Marais BJ, Pai M. Recent advances in the diagnosis of childhood tuberculosis. Arch Dis Child
2007; 92: 446-52
Marais BJ, Rabie H, Schaaf HS, Cotton MF. Common opportunistic infections in HIV-infected
infants and children; Part 1- respiratory infections. SA Fam Pract 2006; 48: 52-6
Marais BJ, Pai M. Specimen collection methods in the diagnosis of childhood tuberculosis.
Indian J Med Microbiol 2006; 24: 249-251
Marais BJ, Gie RP, Schaaf HS, Donald PR, Beyers N, Starke J. Childhood pulmonary
tuberculosis – Old wisdom and new challenges. Am J Resp Crit Care Med 2006;173: 1078-90
Marais BJ. Intra-thoracic tuberculosis in children. Arch Dis Child Ed Pract 2006; 91: ep1-7
Rabie H, Marais BJ, Cotton MF. Maintaining infants and children on anti-retroviral therapy. SA
Fam Pract 2006; 48: 55-60
Rabie H, Marais BJ, Cotton MF. Initiating anti-retroviral therapy in HIV-infected infants and
children. SA Fam Pract 2006; 48: 54-8
Rabie H, Marais BJ, Cotton MF. Preventing and diagnosing HIV infection in infants and
children. Prof Nursing Today 2006; 10: 33-6
Rabie H, Marais BJ, Cotton MF. Preventing and diagnosing HIV infection in infants and
children. SA Fam Pract 2006; 48: 35-41
Marais BJ, Obihara CC, Warren RW, Schaaf HS, Gie RP, Donald PR. The burden of
childhood tuberculosis: a public health perspective. Int J Tuberc Lung Dis 2005; 9: 1305-13
Marais BJ. Childhood tuberculosis – reflections from the frontline. Ped Ann 2004; 33: 695-8
Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Obihara C, Starke JR, Enarson DA, Donald
PR, Beyers N. The natural history of childhood intra-thoracic tuberculosis – A critical review of
the pre-chemotherapy literature. Int J Tuberc Lung Dis. 2004; 8: 392-402.
Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Obihara C, Nelson LJ, Enarson DA, Donald
PR, Beyers N. The clinical epidemiology of childhood pulmonary tuberculosis – A critical
review of the pre-chemotherapy literature. Int J Tuberc Lung Dis. 2004; 8: 278-85
Original research articles in peer reviewed journals
Gurjav U, Jelfs P, Hill-Cawthorne GA, Marais BJ, Sintchenko V. Mycobacterium interspersed
repetitive unit genotype heterogeneity within geospatial hotspots of tuberculosis in a low
incidence setting. Infection, Genetics and Evolution 2015; In press
Gurjav U, Burneebaatar B, Narmandah E, Tumenbayar O, Ochirbat B, Hill-Cawthorne GA,
Marais BJ, Sintchenko V. Spatio-temporal dynamics of multi-drug resistant tuberculosis in
Mongolia. Int J Tuberc Lung Dis 2015; In press
Vanden Driessche K, Hens N, Tilley P, Quon BS, Chilvers MA, de Groot R, Cotton MF,
Marais BJ, Speert DP, Zlosnik JEA. Surgical masks reduce airborne spread of Pseudomonas
aeruginosa in colonized cystic fibrosis patients. Am J Resp Crit Care Med 2015; In press
Khatami A, Sparks RT, Marais B. Paediatric Q fever osteomyelitis managed without
antibiotics. Pediatrics 2015; In press
Dobler CC, Korver S, Batbayar O, Nyamdulam B, Oyuntsetseg S, Bold Tsolmon B, Surmaajav
B, Bayarjargal B, Marais BJ. Multidrug-resistant tuberculosis among first-line treatment failures
in Mongolia. Emerg Infect Dis 2015; In press
Solomons RS, Visser DH, Donald PR, Marais BJ, Schoeman JF, van Furth AM. The
diagnostic value of cerebrospinal fluid chemistry results in childhood tuberculous meningitis.
Child’s Nerv Syst 2015; May 15 [E-pub ahead of print]
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García-Basteiro AL, López-Varela E, Augusto OJ, Gondo K, Muñoz J, Macete E, Jahit
Sacarlal J, Marais B, Alonso PL, Ribó JL. Radiological findings in young children investigated
for tuberculosis in Mozambique. PLoS One 2015; 10(5): e0127323
Dobler CC, Korver S, Batbayar O, Oyuntsetseg S, Tsolmon B, Wright C, Solongo B, Marais BJ.
Success of community-based directly observed TB treatment in Mongolia. Int J Tuberc Lung Dis
2015; 19: 657-62
Thompson K, Marais B, Kesson A, Isaacs D. Malaria in Sydney, Australia: lessons learned
from case management. J Paed Child Health 2015; March 25 [E-pub ahead of print]
Outhred AC, Jelfs P, Suliman B, Hill-Cawthorne GA, Crawford ABH, Marais BJ, Sintchenko V.
Added value of whole genome sequencing for management of highly drug resistant
tuberculosis. J Antimicrob Chemother 2014. Dec 9 [E-pub ahead of print]
Byrne AL, Marais BJ, Mitnick CD, Lecca L, Marks GB. Tuberculosis and chronic respiratory
disease: a systematic review and meta-analysis. Int J Infect Dis 2015; 32: 138-46
Solomons R, Goussard P, Visser DH, Marais BJ, Gie RP, Schoeman JF, van Furth AM.
Chest radiograph findings in childhood tuberculous meningitis. Int J Tuberc Lung Dis
2015; 19: 200-4
Solomons RS, Visser DH, Friedrich SO, Diacon AH, Hoek KGP, Marais BJ, Schoeman JF,
van Furth AM. Improved diagnosis of childhood tuberculous meningitis using more than one
nucleic acid amplification test. Int J Tuberc Lung Dis 2015; 19: 74-80
Portevin D, Moukambi F, Clowes P, Bauer A, Chachage M, Ntinginya NE, Mfinanga E, Said
K, Haraka F, Rachow A, Saathoff E, Mpina M, Jugheli L, Lwilla F, Marais BJ, Hoelscher M,
Daubenberger C, Reither K, Geldmacher C. Performance of the novel TAM-TB assay to
diagnose active tuberculosis in children: a prospective, multi-centre study. Lancet Infect Dis
2014; 10: 931-8
Gurjav U, Jelfs P, Holmes N, Marais BJ, Sintchenko V. Temporal dynamics of prevalent M.
tuberculosis genotypes in New South Wales, Australia. BMC Infect Dis 2014; 14: 455 (p1-8)
Solomons RS, Wessels M, Visser DH, Donald PR, Marais BJ, Schoeman JF, van Furth
AM. Uniform research case definition criteria differentiate tuberculous and bacterial
meningitis in children. Clin Infect Dis 2014; 59: 1574-8
Hill PC, Dye C, Viney K, Tabutoa K, Bissell K, Williams BG, Rony Zachariah R, Brostrom R,
Marais BJ, Harries AD. Mass treatment to eliminate tuberculosis – a neglected strategy. Int J
Tuberc Lung Dis 2014; 18: 899-904
Tagaro M, Harries AD, Kool B, Ram S, Viney K, Marais B, Tarivonda L. Tuberculosis case
burden and treatment outcomes in Vanuatu: reflecting the full age spectrum. Public Health
Action 2014; 4 Suppl 1; S14-8
Matoto V, Viney K, Roseveare C, Colaguiri R, Vivili R, Marais BJ. Burden and spectrum of
disease in people with diabetes in Tonga. Public Health Action 2014; 4 Suppl 1; S44-9
Fanai S, Viney K, Tarivonda L, Roseveare C, Tagaro M, Marais BJ. Profile of tuberculosis
patients with delayed sputum smear conversion in the Pacific island of Vanuatu. Public Health
Action 2014; 4 Suppl 1; S19-24
Morkel G, Bekker A, Marais BJ, Kirsten G, van Wyk J, Dramowski A. Bloodstream infections
and antimicrobial resistance patterns in a South African neonatal intensive care unit. Paediatr
Int Child Health 2014; 34: 108-14
Solomons RS, Elsland SL, Visser DH, Hoek KGP, Marais BJ, Schoeman JF, van Furth AM.
Commercial nucleic acid amplification tests in tuberulous meningitis – a meta-analysis. Diagn
Microbiol Infect Dis 2014: 78: 398-403
Britton PN, Yeung V, Lowbridge C, Isaacs D, Marais BJ. Spectrum of disease in children
treated for tuberculosis at a tertiary children’s hospital in Australia. J Ped Infect Dis 2013: 2:
224-31
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Murray E, Bond V, Marais BJ, Godfrey-Faussett P, Ayles H, Beyers N. High levels of
vulnerability and anticipated stigma reduce the impetus for tuberculosis diagnosis in Cape
Town, South Africa. Health Policy Plan 2013; 28: 410–8
Marais BJ, Mlambo CK, Rastogi N, Zozzio T, Duse A, Victor T, Marais E, Warren RM.
Epidemic spread of multidrug-resistant (MDR) tuberculosis in Johannesburg, South Africa. J
Clin Microbiol 2013; 51: 1818-25
Mandalakas A, Hesseling AC, Schaaf HS, Gie RP, Marais BJ, Sinanovic E. Modeling the
cost-effectiveness of strategies to prevent tuberculosis in child contacts in a high-burden
setting. Thorax 2013; 68: 247-55
Walters E, Reichmuth K, Dramowski A, Marais BJ, Cotton MF, Rabie H. Antiretroviral
regimens containing a single protease inhibitor increase risk of virological failure in young
HIV-infected children. Ped Infect Dis J 2013; 32: 361-3
Kapata N, Chanda-Kapata P, O’Grady J, Bates M, Mwaba P, Janssen S, Marais B, Cobelens
F, Grobusch M, Zumla A. Trends in childhood TB in Zambia: a situation analysis. J Trop
Pediatr 2013; 59: 134-9
Vanden Driessche K, Marais BJ, Wattenberg M, Magis-Esxcurra C, Reijers M, Tuinman IL,
Boeree MJ, van Soolingen D, de Groot R, Cotton MF. The cough cylinder: a tool to study
measures against airborne spread of (myco-) bacteria. Int J Tuberc Lung Dis 2013; 17: 46-53
Cotton M, Marais BJ, Andersson M, Eley B, Rabie H, Slogrove AL, Dramovski A, Schaaf HS,
Mehtar S. Minimizing the risk of nonvertical, nonsexual HIV infection in children – beyond
mother to child transmission. J Int AIDS Soc 2012; 15: 17377
Bhargava A, Pai M, Bhargava, M, Marais BJ, Menzies R. Can social interventions prevent
tuberculosis? – the Papworth experiment (1918-1943) revisited. Am J Resp Crit Care Med
2012: 186: 443-9
Seddon J, Hesseling AC, Marais BJ, Victor T, Schaaf HS. The evolving epidemic of drugresistant tuberculosis among children in Cape Town, South Africa. Int J Tuberc Lung Dis
2012; 16: 928-33
Mukinda F, Theron D, vd Spuy G, Nachega J, Marais BJ, Warren RM, Schaaf HS. Rise in
rifampicin monoresistant tuberculosis in the Western Cape. Int J Tuberc Lung Dis 2012; 16:
196-202
Talukder K, Salim MAH, Jerin I, Sharmin F, Talukder MQ, Marais BJ, Nandi P, Cooreman E,
Rahman MA. Intervention to increase detection of childhood TB in Bangladesh. Int J Tuberc
Lung Dis 2012; 16: 70-7
du Preez K, Hesseling AC, Mandalakas AM, Marais BJ, Schaaf HS. Opportunities for
chemoprophylaxis in children with culture-confirmed tuberculosis. Ann Trop Paediatr 2011;
31: 301-10
Ligthelm LJ, Nicol MP , Hoek KG,Jacobson R, van Helden P, Marais BJ, Warren RM, Wright
CA. Xpert® MTB/RIF for the rapid diagnosis of tuberculous lymphadenitis from fine needle
aspiration biopsy specimens. J Clin Microbiol 2011; 49: 3967-70
Uys P, Marais BJ, Robertson S, Hargrove J, Wood R. Transmission elasticity in communities
hyperendemic for tuberculosis. Clin Infect Dis 2011; 52: 1399-404
Dramowski A, Rabie H, Marais BJ, Kirsten GF, Cotton MF. A case of congenital measles
during the 2010 South African epidemic. Ann Trop Paediatr 2011: 31: 185-8
Rose PC, Schaaf HS, Marais BJ, Gie RP, Stefan DC. Value of bone marrow biopsy in
children with suspected disseminated mycobacterial disease. Int J Tuberc Lung Dis 2011; 15:
200-04
Van Wyk A, Marais BJ, Warren RM, van Wyk S, Wright CA. The value of LED fluorescence
microscopy in fine needle aspiration biopsies of paediatric lymph nodes. Int J Tuberc Lung
Dis 2011; 15: 56–60
Solomons R, Schoeman JF, Marais BJ, van Zyl G, Maritz J, van Toorn R. Acute
extrapyramidal dysfunction in two HIV-infected children. J Trop Ped 2011; 57: 227-31
9
Hesseling AC, Marais BJ, Kirchner HL, Mandalakas AM, Brittle W, Victor TC, Warren RM,
Schaaf HS. Mycobacterial genotype is associated with disease phenotype in children. Int J
Tuberc Lung Dis 2010; 14: 1252-8
Stefan DC, Dippenaar A, Detjen A, Schaaf HS, Marais BJ, Walzl G, Hesseling AC. Interferon–
gamma release assays for detection of Mycobactrium tuberculosis infection in children with
cancer. Int J Tuberc Lung Dis 2010; 14: 689–94
Marais BJ, Hesseling AC, Schaaf HS, Gie RP, van Helden P, Warren RM. Mycobacterium
tuberculosis infection is not related to household genotype in a highly endemic setting. J Clin
Microbiol 2009; 47: 1338-43
Wright CA, Hoek KGP,van Helden P, Marais BJ, Warren RM. Combining Fine Needle
Aspiration Biopsy and High Resolution Melt Analysis to reduce diagnostic delay in
Mycobacterial Lymphadenitis. Diagn Cytopath 2009. 38: 482-8
Wright CA, Hesseling AC, Bamford C, Burgess SM, Warren RW, Marais BJ. Fine needle
aspiration biopsy – a first line diagnostic procedure in pediatric tuberculosis suspects with
peripheral lymphadenopathy. Int J Tuberc Lung Dis 2009; 13: 1373-9
Wright CA, Bamford C, Prince Y, Vermaak A, Hoek KGP, Marais BJ, Warren RM.
Mycobacterial transport medium for routine culture of fine needle aspiration biopsies. Arch Dis
Child 2010; 95: 48-50
Schaaf HS, Victor TC, Engelke E, Brittle W, Hesseling AC, Marais BJ, van Helden PD,
Donald PR. Ethionamide cross- and co-resistance in children with isoniazid-resistant
tuberculosis. Int J Tuberc Lung Dis 2009; 13: 1355-9
Webb EA, Hesseling AC, Schaaf HS, Gie RP, Lombard CJ, Spitaels A, Delport S, Marais BJ,
Donald K, Hindmarsh P, Beyers N. High prevalence of Mycobacterium tuberculosis infection
and disease in children and adolescents with type 1 diabetes mellitus. Int J Tuberc Lung Dis
2009; 13: 868-74
Warren RM, Streicher EM, Gey van Pittius NC, van der Spuy GD, Marais BJ, Victor TC, Sirgel
F, Donald PR, van Helden PD. The clinical relevance of mycobacterial pharmacogenetics.
Tuberculosis 2009; 89: 199-202
Murray EJ, Marais BJ, Mans G, Beyers N, Ayles H, Godfrey-Faussett P, Wallman S, Bond V.
A multidisciplinary approach to map potential TB transmission ‘hot spots’ in high burden
communities. Int J Tuberc Lung Dis 2009; 13: 767-74
Hesseling AC, Johnson LF, Jaspan H, Cotton MF, Whitelaw A, Schaaf HS, Fine PEM, Eley
BS, Marais BJ, Nuttall J, Rabie H, Beyers N, Godfrey-Faussett P. Disseminated bacilli
Calmette-Guerin disease in HIV-infected South African infants. Bull WHO 2009; 87: 505-511
Brittle EW, Marais BJ, Hesseling AC, Schaaf HS, Kidd M, Wasserman E, Botha T. Improved
mycobacterial yield and reduced time-to-detection in pediatric samples using a nutrient broth
growth supplement. J Clin Microbiol 2009; 47: 1287-9
Schaaf HS, Marais BJ, Hesseling AC, Brittle W, Donald PR. Surveillance of antituberculosis
drug resistance amongst children from the Western Cape Province of South Africa – an
upward trend. Am J Public Health 2009; 99: 1486-90
Van der Spuy GD, Kremer K, Ndabambi SL, Beyers N, Dunbar R, Marais BJ, van Helden PD,
Warren RM. Changing Mycobactrium tuberculosis population highlights clade-specific
pathogenic characteristics. Tuberculosis 2009, 81: 120-5
Hesseling AC, Mandalakas AM, Marais BJ, Chegou N, Les Kirchner H, Zhu X, Black G,
Stanley K, Beyers N, Walzl G. Highly discordant T cell responses in individuals with recent
exposure to household tuberculosis. Thorax 2009; 64: 840-6
Marais BJ, Brittle W, Painczyk K, Hesseling AC, Beyers N, Wasserman E, van Soolingen D,
Warren RM. Use of light emitting diode fluorescence microscopy to detect acid-fast bacilli in
sputum. Clin Infect Dis 2008; 47: 203-7
Kruk A, Gie RP, Schaaf HS, Beyers N, Marais BJ. Symptom-based screening of child
tuberculosis contacts: improved feasibility in resource-limited settings. Pediatrics 2008;
121:e1646-52
10
Walters E, Cotton MF, Rabie H, Schaaf HS, Walters LO, Marais BJ. Clinical presentation and
outcome of TB in HIV-infected children on HAART. BMC Pediatrics 2008; 8: 1
Wilson NW, Bouhuijs P, Conradie HH, Reuter R, van Heerden BB, Marais BJ. Perceived
educational value and enjoyment of a rural clinical rotation for medical students. Rural
Remote Health 2008; 8: 999 (1-13)
Wright CA, van der Burg M, Noordzij JG, Burgess SM, Marais BJ. Diagnosing mycobacterial
lymphadenitis in children using fine needle aspiration biopsy: cytomorphology, ZN staining
and autoflourescence – making more of less. Diagnostic Cytopathology 2008, 36: 245-51
Mandalakas AM, Hesseling AC, Chegou N, Kirshner HL, Zhu X, Marais BJ, Stanley K, Beyers
N, Black G, Walzl G. High level of discordant IGRA results in HIV-infected adults and children.
Int J Tuberc Lung Dis 2008, 12: 417-23
Wright CA, Pienaar JP, Marais BJ. Fine needle aspiration biopsy in children – Diagnostic
utility in resource-limited settings. Ann Trop Paediatr 2008; 28: 65-70
Marais BJ, de Villiers M, Kruger J, Conradie H, Jenkins L, Reuter H. The role of educational
strategies to reverse the inverse performance spiral in academically isolated rural hospitals.
SA Fam Pract 2007; 49: 15
Schaaf HS, Marais BJ, Whitelaw A, Hesseling AC, Eley B, Gie RP, Hussey GD, Beyers N,
Donald PR. Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of
596 cases. BMC Infect Dis 2007; 7: 140
Schaaf HS, Victor TC, Engelke E, Brittle W, Marais BJ, Hesseling AC, van Helden PD,
Donald PR. Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium
tuberculosis isolates from children. Eur J Clin Microbiol Infect Dis 2007; 26: 203-5
Den Boon S, Verver S, Marais BJ, Enarson DA, Lombard CJ, Bateman ED, Irusen E, Jithoo
A, Borgdorff MW, Beyers N. Association of passive smoking and Mycobacterium tuberculosis
infection in children. Pediatrics 2007; 119: 724-39
Maree F, Hesseling AC, Schaaf HS, Marais BJ, van Helden P, Beyers N, Schoeman JF,
Warren RM. Absence of an association between Mycobacterium tuberculosis genotype and
clinical features in children with tuberculous meningitis. Ped Inf Dis J 2007; 26: 13-8
Hesseling AC, Marais BJ, Gie RP, Schaaf HS, Fine PEM, Godfrey-Faussett P, Beyers N. The
risk of disseminated bacilli Calmette-Guerin (BCG) disease in HIV-infected children. Vaccine
2007; 25: 14-18
Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Lombard C. Enarson DA, Beyers N. A refined
symptom-based approach to diagnose pulmonary tuberculosis in children. Pediatrics 2006;
118: e1350-9
Marais BJ, Victor T, Hesseling C, Hanekom A, Jooste A, Brittle W, Reuter H, Beyers N, van
Helden P, Warren R, Schaaf HS. Beijing and Haarlem genotype families are over-represented
among children with drug resistant tuberculosis in the Western Cape, South Africa. J Clin
Microbiol 2006; 44: 3539-43
Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Enarson DA, Beyers N. The spectrum of
childhood tuberculosis in a highly endemic area. Int J Tuberc Lung Dis 2006; 10: 732-8
Marais BJ, van Zyl S, Schaaf HS, van Aardt M, Gie RP, Beyers N. Adherence to isoniazid
preventive chemotherapy in children: a prospective community based study. Arch Dis Child
2006; 91: 762-5
Heyns L, Gie RP, Goussard P, Beyers N, Warren RM, Marais BJ. Nosocomial transmission of
M.tuberculosis in kangaroo mother care units: a risk in tuberculosis endemic areas. Acta
Paediatrica 2006; 95: 535-9
Marais BJ, Hesseling AC, Gie RP, Schaaf HS, Enarson DA, Beyers N. Bacteriologic yield in
children with intra-thoracic tuberculosis. Clin Infect Dis 2006. 42:e69-71
Marais BJ, Gie RP, Hesseling AC, Schaaf HS, Enarson DA, Beyers N. Radiographic signs
and symptoms in children treated for tuberculosis: possible implications for symptom-based
screening in resource-limited settings. Ped Infect Dis J 2006; 25: 237-40
11
Marais BJ, Hesseling AC, Gie RP, Schaaf HS, Beyers N. The burden of childhood
tuberculosis and the accuracy of routine surveillance data in a high-burden setting. Int J
Tuberc Lung Dis 2006; 10: 259-63
Marais BJ, Wright CA, Gie RP, Hesseling AC, Schaaf HS, Enarson D, Beyers N. Tuberculous
lymphadenitis as a cause of persistent cervical lymphadenopathy in children from a
tuberculosis-endemic area. Pediatr Inf Dis J 2006; 25: 142-6
Schaaf HS, Marais BJ, Hesseling AC, Gie RP, Beyers N, Donald PR. Childhood drugresistant tuberculosis in the Western Cape Province of South Africa. Acta Paediatrica 2006;
95: 523-8
Obihara CC, Beyers N, Gie RP, Hoekstra M, Fincham JE, Marais BJ, Lombard CJ, Potter PC,
Dini LA, Kimpen JLL. Respiratory atopic disease, Ascaris- IgE and tuberculin testing in urban
South African children. Clin Exp Allergy 2006. 36: 640-8
Engelbrecht AL, Marais BJ, Donald PR, Schaaf HS. A critical look at the diagnostic value of
culture-confirmation in childhood tuberculosis. J Infect 2006; 53: 364-9
Hesseling AC, Rabie H, Marais BJ, Manders M, Lips M, Schaaf HS, Warren RM, Gie RP,
Cotton MF, van Helden P, Beyers N. Bacille Calmette-Guerin vaccine-induced disease in
HIV-infected and HIV-uninfected children. Clin Inf Dis 2006; 42: 548-58
Van Zyl S, Marais BJ, Hesseling AC, Gie RP, Beyers N, Schaaf HS. Adherence to
antituberculosis chemoprophylaxis and treatment in children. Int J Tuberc Lung Dis 2006.
10:13-8
Obihara CC, Kimpen JLL, Gie RP, van Lill SW, Hoekstra MO, Marais BJ, Schaaf HS,
Lawrence K, Potter PC, Bateman ED, Lombard CJ, Beyers N. Mycobacterium tuberculosis
infection may protect against allergy in a tuberculosis endemic area. Clin Exp Allergy 2006;
36: 70-6
Theart AC, Marais BJ, Gie RP, Hesseling AC, Beyers N. Criteria used for the diagnosis of
childhood tuberculosis at primary health care level in a high-burden, urban setting. Int J
Tuberc Lung Dis 2005; 9: 1210-4
Marais BJ, Gie RP, Obihara CC, Hesseling AC, Schaaf HS, Beyers N. Well-defined
symptoms are of value in the diagnosis of childhood pulmonary tuberculosis. Arch Dis Child
2005; 90: 1162-5
Marais BJ, Obihara CC, Gie RP, Schaaf HS, Hesseling AC, Lombard C, Enarson D, Bateman
E, Beyers N. The prevalence of symptoms associated with pulmonary tuberculosis in
randomly selected children from a high-burden community. Arch Dis Child 2005; 90: 1166-70
Marais BJ, Gie RP, Hesseling AC, Beyers N. Adult-type pulmonary tuberculosis in children
aged 10-14 years. Pediatr Inf Dis J 2005; 24: 743-4
Marais BJ, Donald PR, Gie RP, Schaaf HS, Beyers N. Diversity of disease manifestations in
childhood pulmonary tuberculosis. Ann Trop Paed 2005; 25: 79-86
Obihara CC, Beyers N, Gie RP, Potter P, Marais BJ, Lombard C, Enarson D, Kimpern JLL.
Inverse association between M. tuberculosis infection and atopic rhinitis in children. Allergy
2005; 60: 1121-5
Obihara CC, Marais BJ, Gie RP, Potter P, Bateman ED, Lombard C, Kimpen JLL, Beyers N.
The association of prolonged breastfeeding and allergic disease in poor urban children. Eur
Resp J 2005; 25:970-7
Marais BJ, Gie RP, Schaaf HS, Starke JR, Hesseling AC, Donald PR, Beyers N. A proposed
radiologic classification of childhood intra-thoracic tuberculosis. Pediatr Rad 2004; 33: 886-94
Hesseling AC, Schaaf HS, Victor T, Beyers N, Marais BJ, Cotton MF, Wiid I, Gie RP, van
Helden P, Warren R. Resistant M.bovis BCG disease: implications for management of BCGdisease in HIV infected children. Pediatr Inf Dis J 2004; 23: 476-9
Marais BJ, Pienaar J, Gie RP. Kaposi Sarcoma presenting with upper airway obstruction and
bilateral chylothoraces. Pediatr Inf Dis J 2003; 22: 926-7
12
Marais BJ, Cotton M. Occupational exposure to HIV amongst paediatricians, a previously
undescribed high-risk group. Pediatr Inf Dis J 2003; 22: 382-3
Hesseling AC, Schaaf HS, Hanekom WD, Beyers N, Cotton MF, Gie RP, Marais BJ, van
Helden P, Warren RM. Danish BCG Vaccine: Induced Disease in HIV-Infected Children. Clin
Inf Dis 2003; 37: 1226-33
Hesseling AC, Marais BJ, Cotton M. Neurobrucellosis a case report. Ann Trop Paediatr
2003; 23: 145-8
Marais B, Kalis NN, Shipton S, vd Merwe P-L. Complete atrioventricular septal defect.
Cardiovasc. J South Afr. 2000; 11: 210-4
Strijdom JG, Marais BJ, Koeslag JH. Ascorbic acid causes spuriously low blood glucose
measurements. S Afr Med J 1993; 83: 64-5
Editorials/commentaries
Marais BJ. Strategies to improve TB case finding in children. Public Health Action 2015; 5:
90-1
Marais BJ, Graham SM. Childhood tuberculosis – a roadmap towards zero deaths. J Paed
Child Health 2014; June 13 [Epub ahead of print]
Zumla A, Mauerer M, Marais B, Chakaya J, Wesje C, Lipman M, Mc Hugh T, Petersen E.
Commemorating World Tuberculosis Day 2015. Int J Infect Dis 2015; 32: 1-4
Negin J, Abimbola S, Marais BJ. Tuberculosis among older adults – time to take notice. Int J
Infect Dis 2015; 32: 135-7
Graham SM, Grzemska M, Brands A, Nguyen H, Amini J, Triasih R, Talukder K, Ahmed S,
Amanullah F, Detjen A1, Marais B, Hennig C, Islam T. Regional initiatives to address the
challenges of tuberculosis in children: perspectives from the Asia-Pacific region. Int J Infect
Dis 2015; 32: 166-9
Marais BJ. 12-Dose regimen now also an option for preventing tuberculosis in children and
adolescents. JAMA Ped 2015; 169: 208-10
Marais BJ. Urine lipoarabinomannan testing in children with tuberculosis. Lancet Global
Health 2014; 2(5): e245–6
Marais BJ. Quantifying the tuberculosis disease burden in children. Lancet 2014: 383: 1530-1
Graham SM, Sismanidis C, Menzies HJ, Marais BJ, Detjen AK, Black RE. Importance of
tuberculosis to address child survival. Lancet 2014; 383: 1605-7
Marais BJ, Schaaf HS, Graham SM. Child health and tuberculosis. Lancet Resp Med 2014; 2:
254-6
Majumdar SS, Marais BJ, Denholm J, Britton W. Drug-resistant tuberculosis: collaborative
regional leadership required. Med J Austr 2014; 200: 241-2
Marais BJ, Tadolini M, Zignol M, Migliori GB. Paediatric TB – lessons from Denmark and
inclusive strategies to consider. Eur Resp J 2014; 43: 678-84
Marais B, Graham S, Maeurer M, Zumla A. Progress and challenges in childhood
tuberculosis. Lancet Infect Dis 2013; 13: 287-9
Raviglione M, Zumla A, Marais B, Horton H, Matsoaledi A. Advancing a sustainable agenda
for TB control and research. Lancet 2012; 379: 1077-8
Marais BJ. The impact of tuberculosis on maternal and child health. J Infect Dis 2011; 203:
304-5
Atun R. Raviglione M, Marais B, Zumla A. Tuberculosis control is critical to achieving the
MDGs. Lancet 2010; 376: 940-1
Marais BJ, Gupta A, Starke JR, El-Sony A. Tuberculosis in women and children. Lancet 2010;
375: 2057-9
13
Donald PR, Marais BJ, Barry CE 3rd. The influence of age on the epidemiology and pathology
of tuberculosis. Lancet 2010; 375:1852-4
Marais B, Hoelscher M, Mwaba P, Dheda K, Zumla A, World TB Day 2010 – Eradicating
Tuberculosis in sub-Saharan Africa needs effective and committed north-south partnerships.
South Afr Med J 2010; 100: 153-4
Marais BJ. Performing TB research in children; issues to consider. Indian Pediatr 2008; 45:
737-9
Marais BJ. Advances in the clinical diagnosis of TB in children. Pediatr Res 2008; 63: 116
Marais BJ, Kangwana B, Rabie H. Caring for our children. SA Fam Pract 2007; 49: 18
Marais BJ, Pai M. Specimen collection methods in the diagnosis of childhood tuberculosis.
Indian J Med Microbiol 2006; 24: 249-51
Scientific letters
Byrne A, Marais BJ, Mitnick CD, Lecca L, Marks GB. Risk factors for and origins of COPD.
Lancet 2015; 385: 1723-4
Esposito S, D'Ambrosio L, Tadolini M, Schaaf HS, Caminero Luna J, Marais B, Centis R,
Dara M, Matteelli A, Blasi F, Migliori GB. ERS/WHO Tuberculosis Consilium assistance with
extensively drug-resistant tuberculosis management in a child: case study of compassionate
delamanid use. Eur Respir J 2014; 44: 811-5
Marais BJ. Challenges in the use of tests to diagnose tuberculosis infection – in reply. NSW
Public Health Bull 2013; 24: 92-3
Marais BJ, Zumla A. History of tuberculosis and drug resistance. N Engl J Med 2013; 368: 88
Marais BJ, Perez-Velez CM. Tuberculosis in Children – in reply. N Engl J Med 2012; 367:
1568-9
Marais B, Crawford J, Iredell J, Ward M, Simpson S, Gilbert L, Kamradt-Scott A, Jones C,
Sorrell T. One world – One health: beyond the Millennium Development Goals. Lancet 2012;
380: 805-6
Konstantinos A, Simpson G, Sorrell TC, Marais BJ. Doing the right thing for tuberculosis
control in the Torres Strait Islands. Med J Aust 2011; 195: 512
Marais BJ. The role of chest CT in tuberculosis outbreak investigation. Chest 2011; 139: 229
Marais BJ, van Helden PD, Donald PR. Adequacy of 6 month follow-up in chemotherapy
therapy trials. Int J Tuberc Lung Dis 2010; 14: 927-30
Marais BJ. Does finding M. tuberculosis in sputum always equal tuberculosis disease? Am J
Resp Crit Care 2010; 181: 195-6
Marais BJ, Schaaf HS, Gie RP, Donald PR. TB contact screening – which way to go? Int J
Tuberc Lung Dis 2009, 13:1576-9
Marais BJ, van Helden PD. Reconsidering global targets for TB control. Bull WHO 2009, 87:
296-7
Marais BJ. The elephant in the room: the rising cost of healthcare in America. J Ped 2009;
154: 625
Marais BJ, Hesseling AC, Cotton MF. Poverty and TB: is it truly a simple inverse linear
correlation? Eur Resp J 2009; 33: 943-4
Marais BJ, Parker SK, Verver S, van Rie A, Warren RM. Primary and post-primary or
reactivation TB: time to revise confusing terminology? Am J Roentgen 2009; 192: W198
Marais BJ, Schaaf HS, Hesseling AC, Gie RP. TB case definition: time for critical reassessment? Int J Tuberc Lung Dis 2008; 12: 1218-9
Gqada Z, Marais BJ, Bamford C, Orth H, Wasserman E. Clinical rationale for treatment of
endocarditis caused by methicillin-susceptible Staphylococcus aureus developing
nonsusceptibiity to daptomycin. J Clin Microbiol 2008; 46: 2471
14
Hesseling AC, Cotton M, Marais BJ, Gie RP, Schaaf HS, Beyers N, Fine PEM, Abrams EJ,
Godfrey-Fausset P, Kuhn L. BCG and HIV reconsidered: moving the research agenda
forward. Vaccine 2007; 25: 6565-8
Marais BJ, Adams LV. Researchers call for new diagnostic approach to TB. Infect Dis
Children 2004; 17: 36
Marais BJ. Ethics – the third dimension. Arch Dis Child 2004, 89: 1077-8
Marais BJ. Judged by our legacy. Arch Dis Child 2004; 89: 796
Marais BJ. On the definition of relevant disease. Arch Dis Child 2004; 89: 497
Member of author group
Kamradt-Scott A, Harman S, Nunes J, Roemer-Mahler A, Wenham C, on behalf of 95
signatories. WHO must remain a strong global health leader post Ebola. Lancet 2015; 385:
111
Lodha R, Mukherjee A, Singh V, Singh S, Friis H, Faurholt-Jepsen D, Bhatnagar S, Saini S,
Kabra SK, Grewal HM; Delhi Pediatric TB Study Group. Effect of micronutrient
supplementation on treatment outcomes in children with intrathoracic tuberculosis: a
randomized controlled trial. Am J Clin Nutr 2014; 100: 1287-97
Khandelwal D, Gupta N, Mukherjee A, Lodha R1, Singh V, Grewal HM, Bhatnagar S, Singh S,
Kabra SK; Delhi Pediatric TB Study Group. Vitamin D levels in Indian children with
intrathoracic tuberculosis. Indian J Med Res 2014; 140: 531-7
Mukherjee A, Saini S, Kabra SK, Gupta N, Singh V, Singh S, Bhatnagar S, Saini D, Grewal
HM, Lodha R, Delhi Pediatric TB Study group. Effect of micronutrient deficiency on
QuantiFERON-TB Gold In-Tube test and tuberculin skin test in diagnosis of childhood
intrathoracic tuberculosis. Eur J Clin Nutr 2014; 68: 38-42
Lodha R, Mukherjee A, Saini D, Saini S, Singh V, Singh S, Grewal HM, Kabra SK; Delhi
Pediatric TB Study Group. Role of the QuantiFERON®-TB Gold In-Tube test in the diagnosis
of intrathoracic childhood tuberculosis. Int J Tuberc Lung Dis 2013; 17: 1383-8
Mukherjee A, Singh S, Lodha R, Singh V, Hesseling A, Grewal HM, Kabra S; for the Delhi
Pediatric TB Study Group. Ambulatory Gastric Lavages Provide Better Yields of
Mycobacterium Tuberculosis than Induced Sputum in Children with Intra-Thoracic
Tuberculosis. Pediatr Infect Dis J 2013; 32: 1313-7
Parashar D, Kabra SK, Lodha R, Singh V, Mukherjee A, Arya T, Grewal HMS, SinghS, Delhi
Pediatric TB Study Group. Does neutralization of gastric aspirates from children with
suspected intrathoracic tuberculosis affect mycobacterial yields on MGIT culture? J Clin
Microbiol 2013; 51: 1753-6
Siberry GK, Abzug MJ, Nachman S; Panel on Prevention and Treatment of Opportunistic
Infections in HIV-Exposed and HIV-Infected Children. Executive summary: 2013 update of the
guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and
HIV-infected children. Pediatr Infect Dis J. 2013; 32: 1303-7
Siberry GK, Abzug MJ, Nachman S on behalf of the Panel on Guidelines for Prevention and
Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children. Executive
Summary: Guidelines for the Prevention and Treatment of Opportunistic Infections in HIVExposed and HIV-Infected Children. Recommendations from the National Institutes of Health,
the Centers for Disease Control and Prevention, the HIV Medicine Association of the
Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the
American Academy of Pediatrics. J Ped Infect Dis Soc 2013; Nov 27: 1–16
DOI:10.1093/jpids/pit074
Hatherill M, Verver S, Mahomed H; the Taskforce on Clinical Research Issues, Stop TB
Partnership Working Group on TB Vaccines. Consensus Statement on Diagnostic End Points
for Infant Tuberculosis Vaccine Trials. Clin Infect Dis. 2012; 54: 493-501
15
Contribution acknowledged
Seddon JA, Hesseling AC, Finlayson H, Fielding K, Cox H, Hughes J, Godfrey-Faussett P,
Schaaf HS. Preventive therapy for child contacts of multidrug-resistant tuberculosis: a
prospective cohort study. Clin Infect Dis 2013; 57: 1676-84
Schaaf HS, Collins A, Bekker A, Davies PDO. Tuberculosis at the extremes of age.
Respirology 2010; 15: 747-63
Atkins S, Biles D, Lewin S, Ringsberg K, Thorson A. Patients’ experiences of an intervention
to support tuberculosis treatment adherence in South Africa. J Health Serv Res Policy 2010:
163–70
Bakir M, Dosanjh DPS, Deeks JJ, Soysal A, Millington KA, Efe S, Asaln Y, Polat D, Kodalli N,
Yagci A, Barlan I, Bahceciler N, Demiralph EE, Lalvani A. Use of T cell-based diagnosis of
tuberculosis infection to optimize interpretation of tuberculin skin testing for child tuberculosis
contacts. Clin Infect Dis 2009; 48: 302-12.
Cooke ML, Goddard EA, Brown KA. Endoscopy findings in HIV-infected children from subSaharan Africa. J Trop Ped 2009; Jan 15: e1-6
Cotton MF, Schaaf HS, Lottering G, Wever HL, Coetzee J, Nachman S. Tuberculosis
exposure in HIV-exposed infants in a high-prevalence setting. Int J Tuberc Lung Dis 2008; 12:
225-7
Richeldi L, Ewer K, Losi M, Begamini BM, Millington K, Fabbri LM, Lalvani A. T-cell-based
diagnosis of neonatal multidrug-resistant latent tuberculosis infection. Pediatrics 2007; 119:
e1-5
Pai M, O’Brien R. Tuberculosis diagnostics trials: do they lack methodological rigor? Expert
Rev Mol Diagn 2006; 6: 509-14
Ewer K, Millington KE, Deeks JJ, Alvarez L, Bryant G, Lalvani A. Dynamic antigen-specific T
cell responses after point-source exposure to Mycobacterium tuberculosis. Am J Resp Crit
Care Med 2006; 174: 831-9
Ferrara G, Losi M, D’Amico R, Roversi P, Piro R, Meacci M, Meccugni B, Marchetti I,
Andreani A, Bergamini BM, Mussini C, Fabbri LM, Richeldi L. Direct comparison of two
commercial interferon gamma blood tests for the diagnosis of M. tuberculosis infection in
routine clinical practice. Lancet 2006: 367: 1328-34
Soysal A, Millington K, Bakir M, Dosanjh D, Aslan Y, Deeks JJ, Efe S, Staveley I, Ewer K,
Lalvani A. Effect of BCG vaccination on risk of Mycobacterium tuberculosis infection in
children with household tuberculosis contact: a prospective community-based study. Lancet
2005; 366: 1443-51
Diagnostics for tuberculosis – Global demand and market potential. WHO/TDR report 2006.
WHO press, Geneva, Switzerland. ISBN 9241563303
Other publications
Series/Books edited/co-edited
Section editor, Infectious diseases
Current Pediatrics Reports (Elsevier), 2014/15
Lancet TB theme series 2010
Academic editors (Zumla A, Raviglione M, Marais BJ)
Launched during the World Health Assembly – Geneva May 2010
Atlas of Pediatrics in the Tropics
2009, American Academy of Pediatrics; ISBN 978-1-581110-303-8
Chief editors; Spector JM, Gibson TE
Associate editor: Marais BJ
16
Books chapters
PG Textbook of Paediatrics (3 volume set)
2015, Jaypee Brothers Medical Publishers, India
ISBN …….
Chief editors: Gupta P, Menon PSN, Ranji S, Lodha R
Swaminathan S, Pooranagangadevi N, Marais BJ. Tuberculosis. pp 1136-1145
Tuberculosis in Adults and Children
ISBN 978-3-319-19131-7
2015, SpringerBriefs Public Health
Heemskerk D, Caws M, Marais B, Farrar J
Paediatrics and Child Health, 7th edition
2015, Oxford University Press, South Africa
ISBN 978-0-19-90539-4
Chief editor: Green RJ
Cotton MF, Schaaf HS, Rabie H, Marais BJ. Tuberculosis. pp 354-78
Tuberculosis en ninos y jovenes.
2015, Atheneu Hispanica, Sao Paulo, Brazil
ISBN 978-85-388-0572-4
Chief editors: Sant’Anna SC, Loboguerrero MA
Marais BJ. Childhood tuberculosis updates
Tuberculosis
2014, Cold Spring Harbour, USA, ISBN 978-1-621820-73-4
Chief editors: Kaufmann S, Rubin, Zumla A
Marais BJ, Schaaf HS, Graham S. Tuberculosis in children. pp 557-78
Bates M, Marais BJ, Zumla A. Tuberculosis co-morbidity with communicable and noncommunicable diseases. pp 615-30
European Respiratory Monograph
2012, European Respiratory society, Norwich, UK
ISBN 978-1-84984-027-9
Chief editors: Lange C, Migliori GB, Welte T
Marais BJ, Schaaf HS, Menzies D. Prevention of tuberculosis in areas of high incidence. pp
84-94
Progress in Respiratory Research - Antituberculosis chemotherapy
2011, Karger, Basel, Switzerland; ISBN 978-3-8055-9627-5
Chief Editors: Donald PR, van Helden PD
McNeely D, Lin J, Raouf A, Marais BJ. The regulatory environment for the evaluation of new
tuberculosis drugs in children. pp 235-42
Hot Topics in Infection and Immunity in children VIII
2011, Springer USA
ISBN 978-1-4614-0203-9
Chief Editors: Curtis N, Finn A, Pollard A
Marais BJ. What do we know about how to treat TB? pp 171-84
Essentials of tuberculosis in children, 4th edition
2011, Jaypee Brothers Medical Publishers, India
ISBN 978-93-5025-252-9
Chief editors: Seth V, Kabra SK
Marais BJ, Donald PR. Tuberculous lymphadenitis. pp 122-7
Marais BJ, Donald PR. Tuberculosis in HIV-infected children. pp 218-22
Marais BJ, Ling D, Pai M. New approaches to TB diagnosis in children. pp 380-91
Integrated management of HIV/TB/STIs – a training manual for nurses in South Africa
2010, Juta Health publishers, South Africa
ISBN 978-0-70-218664-6
Contributed to and reviewed chapters on HIV & TB
17
Oxford Handbook of HIV medicine, 2nd edition
2009, Oxford University Press, South Africa
ISBN 978-0-19-576135-1
Jeena P, Marais BJ, Schaaf HS. Paediatric tuberculosis. pp 162-72
Coovadia’s Paediatrics and Child Health, 6th edition
2009, Oxford University Press, South Africa
ISBN 978-0-19-598843-7
Cotton MF, Schaaf HS, Rabie H, Marais BJ. Tuberculosis. pp 362-86
Tuberculosis - a comprehensive clinical reference
2009, Elsevier, UK; ISBN 978-1-4160-3988-4
Chief Editors: Schaaf HS, Zumla A
Marais BJ, Donald PR. Natural history of tuberculosis infection and disease in children. pp
133-45
Graham S, Marais BJ, Gie RP. Clinical features and index of suspicion of TB in children. pp
154-63
Marais BJ, Donald PR, Schaaf HS. Management algorithms for paediatric tuberculosis. pp
323-31
Marais BJ, Graham S. Tuberculosis lymphadenitis and involvement of the reticulo-endothelial
system in children. pp 391-6
Marais BJ, Wright CA. Extrapulmonary tuberculosis in children – an illustrative case report. pp
823-5
Tuberculosis
2009, 2nd edition, Jaypee Brothers Medical Publishers, India
ISBN 978-81-8448-514-1
Chief editors: Sharma SK, Mohan A
Marais BJ, Pai M. Diagnosis of childhood tuberculosis: recent advances and applicability of
new diagnostic tools. pp 602-14
Pediatric Practice: Infectious Diseases
2009, McGraw-Hill, USA
ISBN 978-0-07-148924-9
Chief editor: Samir Shah
Marais BJ. Childhood tuberculosis. pp 332-49
Hot topics in infection and immunity in children V
2009, Springer, USA
ISBN 978-0-387-79837-0.
Chief Editors: Finn A, Curtis N, Pollard A
Marais BJ. Childhood intra-thoracic tuberculosis. pp129-46
BMJ Clinical Evidence Handbook, December 2008
2008, BMJ Publishing Group Ltd, UK
ISBN 978-1-905545-33-9
Volmink J, Marais BJ. HIV: mother to child transmission. pp 244-51
Tuberculosis management for doctors: Paediatric module
2007, Foundation for professional development, SA
Essentials of tuberculosis in children, 3rd edition
2006, Jaypee Brothers Medical Publishers, India
ISBN 81-8061-709-2
Chief editors: Seth V, Kabra SK
Marais BJ, Donald PR. Tuberculous peripheral lymphadenitis. pp 134-42
How to live with TB? - A guide for people with TB and their friends
2006, Booklet published by the Treatment Action Campaign (TAC), South Africa
Assisted with content and editing
Diagnostics for tuberculosis – Global demand and market potential. WHO/TDR report 2006.
WHO press, Geneva, Switzerland. ISBN 9241563303
18
On-line talks
Marais, B.J. (2013), "TB in children", in Raviglione, M. and Nunn, P. (eds), Tuberculosis: The
Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London
(online at http://hstalks.com/?t=BL1533266-Marais )
Non-peer reviewed journals
Marais BJ. Tuberculosis in children. Australian Doctor; 6 December 2013; pp25-32
Marais BJ. Update on childhood tuberculosis. Pulmao RJ (Rio de Janeiro Lung) 2013; 22: 5864
Marais BJ. How to treat: tuberculosis. Australian Doctor; 30 August 2013: pp27-34
Marais BJ, Sorrel T, Britton W. Drug-resistant tuberculosis in Papua New Guinea and the
Torres Strait islands. The Conversation; November 2012. http://theconversation.edu.au/drugresistant-tuberculosis-in-png-and-torres-strait-islands-10754
Triccas J, Marais B. New vaccines, drugs and diagnostics urgently needed to halt the spread
of tuberculosis. Croakey blog; October 2012
http://blogs.crikey.com.au/croakey/2012/11/08/new-vaccines-drugs-and-diagnostics-urgentlyneeded-to-halt-the-spread-of-tuberculosis/
Dramowski A, Finlayson H, Marais BJ, Rabie H, du Preez M, Malek E, Kruger M, Cotton MF.
Tygerberg Children’s Hospital perspective of the Western Cape’s measles epidemic. FIDSSA
Quaterly, June 2010.
Marais BJ. Childhood intra-thoracic tuberculosis. Specialist Forum 2007; 4: 26-35
Official reports/guidelines
2015
Assistance with the Australian Respiratory Council (ARC) training module for the Pacific
Islands on “TB in children – maternal and paediatric TB”
WHO childhood tuberculosis program review and assessment of new Child TB action plan
Indonesia
Contributed to the WHO rGLC mission report on drug-resistant tuberculosis in Papua New
Guinea (drafted the executive summary)
Contributed to the TB information brochure distributed at the World TB day event in Canberra
2014
Contributed to the WHO Joint TB program review report for Papua New Guinea (drafted the
executive summary)
Composed the TB information brochure distributed at the World TB day event in Canberra
Contributed to the Child TB Roadmap – launched in Washington, USA
Contributed to 2014 revision of “Management of multidrug-resistant tuberculosis in children: a
field guide. The Sentinel Project on Drug-Resistant Tuberculosis. Boston, USA”
2013
Contributed to British All Party Parliamentary Group on Global TB (APPG-GTB). Drug
Resistant Tuberculosis: Old Disease - New Threat. April 2013
Contributed to the WHO Child TB Fact Sheet – distributed on World TB day 2013, which was
dedicated to children
Lead author of the Mycobacterium tuberculosis section in Guidelines for the Prevention and
Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children. Available at
http://aidsinfo.nih.gov/contentfiles/lvguidelines/oi_guidelines_pediatrics.pdf.
Recommendations from the Centers for Disease Control and Prevention (CDC), the National
Institutes of Health (NIH), the HIV Medicine Association of the Infectious Diseases Society of
America (IDSA), the Pediatric Infectious Diseases Society (PIDS), and the American
Academy of Pediatrics (AAP)
19
2012
Contributed to Management of multidrug-resistant tuberculosis in children: a field guide. The
Sentinel Project on Drug-Resistant Tuberculosis. Boston, USA; November 2012
Contributed to WHO Joint TB program review report Cambodia
Assisted Malaysia with updating their national guidance documents for tuberculosis
2011
Contributed to a briefing paper for UNICEF, WHO and UNAIDS on the impact of and
response to TB and HIV-related TB in pregnant women and mothers – linking the “3 I’s” and
PMTCT
Contributed to WHO MDR-TB program review report Vietnam
2010
Assisted with the formulation of national guidance documents for childhood tuberculosis in
Bangladesh, Botswana, Ethiopia, Indonesia, Lesotho, Philippines & Swaziland
WHO reviews: Child TB program review Bangladesh / Assisted with formulation of a national
strategy to improve childhood TB service delivery in Bangladesh
Contributed to the Western Cape guidance on TB prevention in infants born to mothers with
TB and the National consensus statement on INH preventive therapy in HIV infected children
2009
Coordinator of the South African National TB Control Program guidance on childhood
tuberculosis
MANUSCRIPTS/PROPOSALS/THESES REVIEWED
Manuscripts reviewed for the following journals
Acta Paediatrica
AIDS
American Journal of Respiratory and Critical Care Medicine
American Journal of Tropical Medicine and Hygiene
Antimicrobial Agents and Chemotherapy
Archives of Diseases in Childhood
Archives of Pediatrics & Adolescent Medicine
BMC Infectious Diseases
BMC Micobiology
BMC Pediatrics
BMC Public Health
British Medical Journal
Bulletin of the World Health Organization
Canadian Medical Association Journal
Chest
Clinical Infectious Diseases
Cochrane Effective Practice and Organisation of Care (EPOC) Group
Emerging Infectious Diseases
European Respiratory Journal
European Journal of Pediatrics
European Journal of Clinical Microbiology and Infectious Diseases
Expert Review Microbiology
Expert Review Respiratory Medicine
Genes and Immunity
International Journal of Infectious Diseases
International Journal of Tuberculosis and Lung Disease
Lancet
Lancet Neurology
Lancet Infectious Diseases
Lancet Global Health
Journal of Infection
20
Journal of Infectious Diseases
Journal of Pediatric Infectious Diseases
Journal of the Pediatric Infectious Diseases Society
Journal of Paediatrics and Child Health
Journal of Tropical Medicine
Medical Principles and Practice
Pediatric Infectious Diseases Journal
Pediatrics
Pediatrics International
PLoS Medicine
PLoS One
Respiratory Care
Respiratory Medicine
Rural and Remote Health
Scandinavian Journal of Infectious Diseases
South African Medical Journal
South African Journal of Epidemiology and Infection
Thorax
Transactions of the Royal Society of Tropical Medicine and Hygiene
Tropical Medicine and International Health
Vaccine
World Journal of Pediatrics
Yonsei Medical Journal
Project proposals reviewed for the following funding bodies
British Medical Research Council
FIDELIS – Fund for Innovative DOTS Expansion through Local Initiatives to Stop TB
AERAS – Coordinating TB vaccine development and assessment
Italian Ministry of Health
Medical Research Council (MRC) of South Africa
National Research Foundation (NRF) of South Africa
National Institutes of Allergy and Infectious Diseases (NIAID) & Johns Hopkins University as
Expert Scientific Panel member of the Clinical Diagnostics Research Consortium (CDRC)
Research Council of Norway
Rolex awards
SATBAT TB/HIV research support project
The Thrasher Research Fund
Australian National Health and Medical Research Council (NHMRC)
External project reviewer – 2011, 12, 13, 14, 15
Vice-chair project review panel (group 4D) – 2013
Project review panel member (Microbiology & virology) - 2014
Theses reviewed for the following universities / institutes
All India Institute of Medical Science (AIIMS), New Delhi, India
Aarhus University, Denmark
Macquarie University, Australia
Monash University, Australia
Stellenbosch University (SU), South Africa
University of the Witwatersrand (WITS), South Africa
University of Cape Town (UCT), South Africa
University of Copenhagen, Denmark
University of Malawi (College of Medicine), Malawi
University of Melbourne, Australia
University of New South Wales (UNSW), Australia
AWARDS
2012
Top ranked applicant NHMRC career development fellowship (level 1)
2011
Post-doctoral Fellow, University of Sydney
2010
South African National Science and Technology Forum (NSTF) awards – finalist
21
(Category - Individual through research and its output)
*National Research Foundation of South Africa (NRF) – B1 rating
World Society of Pediatric Infectious Diseases (WSPID) world conference Buenos
Aires, Argentina – best oral presentation
2007
Outstanding review award from Clinical Infectious Diseases (CID)
Stellenbosch University, Award for Research Excellence
2006
Colleges of Medicine of SA, Phyllis Knocker/Bradlow award for research excellence
2003-05 Medical Research Council (MRC) PhD fellowship
AstraZeneca Respiratory Research Fellowship awarded by the South African
Thoracic Society (SATS)
Alwyn Zoutendyk Scholarship Trust research award
2009
RESEARCH FUNDING
2014
Australian NHMRC project grant - APP1081443
Prevention of multi-drug resistant tuberculosis in a high prevalence setting: ‘Connecting the
DOTS’ in Vietnam
$3.6 million (2014-2018)
CI-A Greg Fox G – CI-E
Australian NHMRC Centre of Research Excellence (CRE)
Infectious Diseases Modelling to Inform Policy
$2.5 million (2014-2019)
CI-A Jodie McVernon (University of Melbourne) - AI
2012
Australian NHMRC Centre of Research Excellence (CRE)
Tuberculosis Control: From Discovery to Public Health Practice and Policy
$2.5 million (2012-2016)
CI-A Warwick Britton (Centenary Institute, University of Sydney) - CI-B
Australian NHMRC project grant - APP1044986
Mechanisms and markers of tuberculosis transmission within Australia
$772 199 (2013-2015)
CI-A Vitali Sintchenko (CIDM Public Health & University of Sydney) - CI-B
NHMRC Career Development Fellowship – APP 1053911
Tuberculosis – transmission, drug resistance and strain emergence
$278 407 (2013-2016)
2011
Canadian Research Council funding
A randomized trial to compare effectiveness of 4 months Rifampin (4 RIF) with 9 months
Isoniazid (9 INH) in the prevention of active TB in children: The P4v9 Trial
$ 1 million (2011–2015)
PI. Dick Menzies (McGill University, Canada) - Child TB expert advisor
Australian NHMRC Centre of Research Excellence (CRE)
Immunization in under-studied and special risk populations
$2.5 million (2011-2019)
CI-A Raina MacIntyre (University of New South Wales) - AI
2010
European Union funding - EDCTP 38822
TB Child - Evaluation of new and emerging diagnostics for childhood in high burden countries
$2 million (2010-2013)
PI Klaus Reither, Swiss Tropical Institute - Child TB expert advisor
2009
USA National Institutes of Health (NIH) - DMID 07-0061
The utility of interferon-gamma release assays in TB-HIV co-infected children
22
$200 000 (2009-2011)
PIs Anneke Hesseling (Stellenbosch University), Anna Mandalakas (Case Western Reserve
University, USA) – Co-investigator
South African National Research Foundation (NRF)
Direct research support as an internationally rated scientist
$80 000 (2009-2012)
2006
Western Province Department of Health (South Africa)
Maintenance of Competence (MoComp) project
$200 000 (2006-2007) - Principal investigator
2005
South African Medical Research Council (MRC)
Telemedicine project
$100 000 (2005-2007) - Co-investigator
2004
Norwegian Research Council funding
TB in the 21st century – evaluating the impact of strain evolution on the global TB epidemic
$ 250 000 (2004-2008)
PI Gunnar Bjune, Oslo University, Norway – South African coordinator ($80 000)
2003
South African Medical Research Council (MRC) PhD Scholarship
Childhood tuberculosis – evaluating the diagnosis and burden of disease
$90 000 (2003-2005)
EDITORIAL BOARD / EXPERT ADVISORY GROUP / CONSULTANT
Editorial Board
PLoS ONE
- Editorial Board (2007-2012)
JAMA Pediatrics
– International Advisory Board (2009 to date)
European Journal of Pediatrics
– International Advisory Board (2010 to date)
Scientific Advisory Board
NHMRC Centre for Research Excellence in Critical Infections (2011 to date)
Medicins Sans Frontieres (MSF) Epicentre; TB scientific advisory board (2010 to date)
Expert advisory group member
NSW Health Tuberculosis Advisory Committee (TBAC) (2011 to date)
International Scientific Advisory Expert Group to the UK All Party Parliamentary Group on
Global Tuberculosis (APPG TB) (2011 to date)
WHO Western Pacific (WPRO) regional Green Light Committee (rGLC) for multidrug resistant
TB (2011 to date)
Steering Committee of the Sentinel Project on Pediatric Drug-Resistant Tuberculosis (2011 to
date)
WHO Child TB working group (2009 to date)
23
WHO TB Expert group (2009 to date)
US-CDC Global Technical assistance partner (CDC-RFA-GH13-1369); with University of
Columbia (ICAP); areas of PMTCT & HIV pediatric care and treatment (2013)
The National Institutes of Allergy and Infectious Diseases (NIAID) & Johns Hopkins University
- Expert Scientific Panel for the Tuberculosis Clinical Diagnostics Research Consortium
(CDRC) (2010-12)
NIAID Pediatric HIV group, Opportunistic infections - Tuberculosis (2010 to 2012)
Expert advisor to the Child Health and Nutrition Knowledge Network (CHNKN), New Delhi,
India (2010-12)
Consultant to
WHO Tuberculosis Control Programme (2009 to date)
LEADERSHIP
Common purpose – Meridian graduate 2010
Health Sciences Faculty, Leadership Circle program 2010
2013-14
Founding member Australian Tuberculosis Forum (ATF) and the Western
Pacific region Child TB Task Force
2006-10
- Chairman of the Childhood TB working group of the International Union
Against Tuberculosis and Lung Disease (IUATLD)
- Coordinator of IUATLD endorsed annual International Child TB training
course, Cape Town, South Africa
2008-10
- Founding & executive committee member of the Southern African
Society of Pediatric Infectious Diseases (SASPID), African Pediatric
Infectious Diseases Society (AfSPID) co-founder in 2010
- Executive committee member; Western Cape Provincial Paediatric HIV &
TB advisory committee
- Departmental coordinator of the annual Academic Year Day
2007-08
- Coordinator of the revised 2008 SA National Child TB Guidelines
- Coordinator of the Rural Clinical School working group and Acting
Director of the Ukwanda Centre for Rural Health, Stellenbosch University
2003-08
Child TB research group convener, Desmond Tutu TB Research Centre,
Stellenbosch University
1999-2000
Registrar Representative, Tygerberg Hospital, South Africa
1997
SHO representative, St. Mary’s Hospital, United Kingdom
1995
Intern Representative, George Provincial Hospital, South Africa
1993
- Stellenbosch University Colours for Leadership
- Chairman, Medical Residence Committee
1992
- Chairman of the Federation of African Medical Students’ Associations
(FAMSA- East, Central and Southern Africa)
- Vice-Chairman, Medical Students’ Council, Stellenbosch University
- Executive committee South African Medical Students’ Association
- Vice-Chairman, Medical Residence Committee, Stellenbosch University
CONFERENCES/COURSES (Presented and/or organized – since 2008)
2015
World Society of Pediatric Infectious Diseases (WSPID) conference, Rio de Jainero,
Brazil – Invited speaker
24
5th Asia Pacific conference of the International Union Against Tuberculosis and Lung
Disease (IUALTD), Sydney, Australia – Scientific Programme Committee, Invited
speaker
Tuberculosis Drug Development Workshop, Sydney, Australia – Invited speaker
International Tuberculosis Meningitis Meeting, Dalat, Vietnam (Oxford group) –
Invited speaker, Session chair
IUATLD World Conference, Cape Town South Africa; Child TB session - Chair
2014
WHO Seventh TB control meeting for the Pacific Islands, Nadi, Fiji - Invited
speaker/facilitator
Global consultation on Childhood TB in High Burden countries of the Eastern
Mediterranean, South East Asia and Western Pacific Regions, Jakarta, IndonesiaInvited speaker/facilitator
Australian Institute of Tropical Health and Medicine (AITHM) and Queensland
Tropical Health Alliance (QTHA) meeting, Cairns Australia – Invited speaker
Tuberculosis seminar, Aarhus University, Denmark – Invited speaker
Global Health seminar, Swiss Tropical and Public Health Institute, University of
Basel, Switzerland – Invited speaker
European Respiratory Society conference, Munich, Germany - Invited speaker,
Session chair
McGill TB research methods course, Montreal, Canada - Invited speaker
International AIDS Society (IAS) conference, Melbourne, Australia - Invited speaker
Tuberculosis Modeling and Clinical Care, Woolcock Institute, Sydney, Australia Invited speaker, Session chair
Sydney, Australia - Invited speaker, Session chair
Ministry of Health Malaysia, Programmatic Management of Drug Resistant TB
workshop, Kuala Lumpur, Malaysia, Invited speaker
International Society of Infectious Diseases (ISID) conference, Cape Town, South
Africa - Invited speaker, Session chair
WHO workshop to develop a Childhood TB strategic plan for the Western Pacific
region. Ho Chi Ming City, Vietnam - Invited speaker/facilitator
2013
World Society of Pediatric Infectious Diseases (WSPID) conference, Cape Town,
South Africa, Invited speaker
INDVAC, 4th Advanced Vaccinology Course, CMC Vellore, India - Invited
speaker/facilitator
Pacific Islands Operational Research Course, Auckland, New Zealand – Invited
facilitator/mentor
Burnet Institute TB symposium. Advances in tuberculosis: Australian and regional
perspectives. Melbourne, Australia – Invited speaker / panel member
Woolcock, Advanced course in Tuberculosis, Sydney, Australia - Invited speaker,
Session chair
NIH/NIAID workshop. Towards earlier involvement of children and pregnant women
in trials of new TB drugs. Washington, USA – Invited speaker
World TB Day seminar - launch of the Lancet ID TB series, UCL London, UK Invited speaker
International Meeting on Childhood Tuberculosis, Padua, Italy – Invited speaker
2012
6th Asian Congress of Pediatric Infectious Diseases (ACPID), Colombo, Sri Lanka Invited speaker, Session chair
25
14th Asia Pacific Congress of Pediatrics and Pediatric Nursing, Kuching, Sarawak
Malaysia – Invited speaker, Session chair
Pacific Islands Operational Research Course, Nadi, Fiji – Invited facilitator/mentor
Woolcock, Advanced course in Tuberculosis, Sydney, Australia - Invited speaker
Australia’s Global Role in Child Survival; RESULTS International and the University
of Sydney. Sydney – Invited speaker
Pediatric Infectious Diseases Society of the Philippines (PIDSP) annual conference,
Manila, Philippines – Invited speaker
University of Copenhagen Global Health seminar, Denmark– Invited speaker
Medicins Sans Frontieres (MSF) TB scientific advisory committee meeting, Paris,
France
2011
World Society of Pediatric Infectious Diseases (WSPID) conference, Melbourne,
Australia - Invited speaker / Session chair
IUATLD World Conference, Lille, France; Child TB workshop & session - Chair
European Society for Paediatric Infectious Diseases (ESPID) conference, The
Hague, Netherlands – Invited speaker
ANZAHPE Medical Education conference, Alice Springs, Australia – speaker
Woolcock, Advanced course in Tuberculosis, Sydney, Australia - Invited speaker
National TB Control Program Conference and Pediatric Respirology meeting,
Jakarta, Indonesia - Invited speaker/facilitator
WHO/ECDC Child TB working group, Stockholm, Sweden – Invited speaker
2010
IUATLD world conference, Berlin, Germany – Invited speaker
Child TB working group - Convenor
MSF Epicentre research project Mbarara, Uganda – Child TB advisor
WHO – Bangladesh Child TB training initiative – Consultant/organizer
IUATLD International Child TB training workshop, SA - Course organizer
Asian Society of Pediatric Infectious Diseases (ASPID), Taipei, Taiwan – Invited
speaker
WHO expert, Child TB trainer/course facilitator – Dhaka, Bangladesh
Trainer - South to South and PEPFAR TB/HIV Integration Projects
Infection and Immunity, Oxford, UK - Invited speaker
2nd SA National TB conference, Durban, South Africa
URC & CDC Child TB workshops – Invited speaker
Lancet TB series launch at World Health Assembly (WHA) Geneva, Switzerland
Invited speaker / co-editor
Philippines Child TB Training Guidance – Expert advisor
Rede-TB International TB Symposium, Rio de Janeiro, Brazil
Child TB workshop – Invited speaker / workshop facilitator
US-SA joint research forum on TB, Johannesburg, SA
Organized by the NIH and MRC - Invited speaker / participant
WHO/TDR Child TB “Diagnostic reference standard” working group meeting,
Geneva, Switzerland – Invited speaker / participant
Summer Institute in Clinical Trials Research Methods, University of Cape Town in
collaboration with George Washington University, Cape Town, SA – Invited speaker
26
COURSES/WORKSHOPS (ATTENDED)
2011
Post-graduate supervision course, University of Sydney, Australia
Effective clinical skills teaching workshop, University of Sydney, Australia
2010
Infection and Immunity in Children 2010, Keble College, Oxford, UK
Undergraduate teaching workshop, Stellenbosch University, South Africa
2008
The Denver TB course, National Jewish Health, Denver, Colorado, USA
Advanced Neonatal Life Support course, Cape Town, South Africa
Basic Life Support (refresher) course, Cape Town, South Africa
2007
Post-graduate supervision course, Stellenbosch University, South Africa
Good Clinical Practice (GCP) update, SAPCRA, Stellenbosch, South Africa
Summer Institute in Clinical Trials Research Methods, Fogarty funded training
program with George Washington University, Cape Town, South Africa
2006
IRENSA Research Ethics course (Fogarty Center), Cape Town, South Africa
Post-graduate supervision course, Stellenbosch, South Africa (SA)
2005
Innate Immunity in the lung, Embo Novartis foundation workshop, Cape Town, SA
IUATLD training course, Monitoring tuberculosis control services, Cape Town, SA
Infection and Immunity in Children 2005, St. Catherine’s College, Oxford, UK
2004
IRENSA Research Ethics course (Fogarty Center), Cape Town, SA
Infection and Immunity in Children 2004, Keble College, Oxford, UK
Pediatric AIDS Clinical Trials Group (PACTG) International Clinical Training
Program, Red Cross Children’s Hospital, Cape Town, SA
Grantsmanship course, Stellenbosch, SA
2003
Good Clinical Practice (GCP) Course, SAPCRA, Stellenbosch University, SA
2002
Research Methods for the Promotion of Lung Health, IUATLD, Nairobi, Kenya
ISID HIV/AIDS training program, NIH, Bethesda, Maryland, USA
2001
Epidemiology and Biostatistics course, Stellenbosch University, SA
1999
Advanced Paediatric Life Support (APLS) course, Cape Town, SA
1997
MRCP 2 (Paeds) training course, UK
MRCP 1 (Paeds) training course, UK
1996
Advanced Cardiac Life Support (ACLS) course, Salisbury, UK
TEACHING
University of Sydney (present)
Sydney Medical Program (lecturer in paediatric infectious diseases)
BMedSci (lecturer)
Master in Paediatrics – On-line course facilitator (lecturer)
Master in Infection & Immunity - Global Control of Infectious Diseases (lecturer)
Master of Medicine (HIV, STIs and Sexual Health) – Paediatric aspects (lecturer)
Masters in International Public Health - Global Communicable Disease Control (lecturer)
Mater in Health Security - Assisted with course development
Stellenbosch University (past)
Undergraduate course coordinator for Paediatrics
Masters in Clinical epidemiology – Assisted with course development; Module coordinator
PROFESSIONAL MEMBERSHIPS
Founding member Australasian Tuberculosis Forum (ATF)
Member Australasian Society of Infectious Diseases (ASID)
Member International Society of Infectious Diseases (ISID)
Member International Union Against Tuberculosis and Lung Disease (IUATLD; The Union)