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CURRICULUM VITAE PERSONAL DATA Francisco Bracho, MD Department of Pediatrics Division of Pediatric Hematology/Oncology Lombardi Cancer Center Georgetown University Hospital 3800 Reservoir Rd Washington DC 20007 EDUCATION 1984-1989 University of California at Los Angeles, CA Bachelor of Science, Microbiology 1989-1993 University of California at Los Angeles School of Medicine, Doctor of Medicine 1993-1996 University of Southern California, Dept of Pediatrics Pediatric Resident POST DOCTORAL TRAINING 1996-1998 1998-1999 APPOINTMENT 2000-present RESEARCH 2003-present 2004-present 2000-present Children’s Hospital Orange County California Fellow, Hematology/Oncology Pediatric Branch National Cancer Institute, Basic Research at Georgetown University Medical Center, Fellow Hematology/Oncology Assistant Professor of Clinical Pediatrics, Georgetown University Hospital Principal Investigator, US. A Randomized, Double Blind, Placebocontrolled, Multicenter Study of a Subcutaneous Formulation of Icatibant for the Treatment of Hereditary Angioedema. Sponsor Jerini AG Principal Investigator. GUH. A randomized, placebo-controlled, doubleblind Phase II study of the safety and efficacy of recombinant human C1 inhibitor for the treatment of acute attacks in patients with hereditary angioedema. Sponsor Pharming NV Co-Investigator, GUH. Children’s Oncology Group 2006 GRANT 2004 Principal Investigator GUH, Expanded Access Protocol: Safety and Efficacy of Varicella Zoster Immune Globulin (Human) (VariZIG™) in Patients At-Risk of Varicella Infection. Sponsor Cangene Corp. Jerini AG Principal Investigator, US. A Randomized, Double Blind, Placebo-controlled, Multicenter Study of a Subcutaneous Formulation of Icatibant for the Treatment of Hereditary Angioedema CERTIFICATION: Medical License, District of Columbia # MD313355 Medical License, California (1993-1998) 1993 Diplomate National Board of Medical Examiners 1996&2003 Diplomate National Board of Pediatrics 2002 Diplomate Subboard Pediatric Hematology/Oncology HONORS & AWARDS: 1984-1993 1989 1989 1992 1992 1993 1994 1998 Regent’s Scholar University of California (Awarded as undergraduate and Medical Student) Magna cum Laude University of California, Los Angeles Phi Beta Kappa, UCLA McLean Scholar, National Medical Fellowships Awardee National Hispanic Scholarship Fund Alpha Omega Alpha, UCLA SOM Recognition of Service to Community, UCLA Chicano Latino Medical Student Association Awarded Clinical Oncology Research Training Program Grant (K12), Lombardi Cancer Center TEACHING ACTIVITIES 2000-present Lecturer First Year: Clinical Correlate, Sickle Cell Anemia, Biochemistry, Georgetown University School of Medicine 2001-present Lecturer Second Year: Hematopoiesis and hematologic disorders, Pathology, Georgetown University School of Medicine COMMITTEE AND ADMINISTRATIVE SERVICE 2000—Present Member Clinical Research Committee, Lombardi Cancer Center 2000—Present Chair, Pediatric Tumor Board 2000—Present Quality Assurance, Pediatric Inpatient Floor 2004—Present Medical Board, Childhood Brain Tumor Foundation 2005—Present Member, MedStar Oncology Institutional Review Board PUBLICATIONS: 1. Bracho F. Hereditary angioedema. Curr Opin Hematol. 2005 Nov;12(6):493-8. Review 2. Bracho F, van de Ven C, Areman E, Hughes RM, Davenport V, Bradley MB, Cai JW, Cairo MS. A comparison of ex vivo expanded DCs derived from cord blood and mobilized adult peripheral blood plastic-adherent mononuclear cells: decreased alloreactivity of cord blood DCs. Cytotherapy. 2003;5(5):349-61. 3. Goldman SC, Bracho F, Davenport V, Slack R, Areman E, Shen V, Lanarsky C, Weinthal J, Hughes R. Cairo MS. Feasibility study of IL-II and granulocyte colony-stimulating factor after myelosuppressive chemotherapy to mobilize peripheral blood stem cells from heavily pretreated patients. J Pediatr Hematol Oncol. 2001 Jun-Jul;23 (5):300-5. 4. Houtenbos I, Bracho F, Devenport V, Slack R, van de Ven C, Suen Y, Killen R, Shen V, Cairo MS. Autologous bone marrow transplantation for childhood acute lymphoblastic leukemia: a novel combined approach consisting of ex vivo marrow purging, modulation of multi-drug resistance, induction of autograft vs leukemia effect, and post-transplant immuno-and chemotherapy (PTIC). Bone Marrow Transplant 2001 Jan;27 (2):145-53. 5. Bracho F, Krailo MD, Shen V. Bergeron S, Davenport V, Liu-Marces W, Blazer BR, Panoskaltsis-Mortari A. van de Ven C, Secola R, Ames MM, Reid JM, Reaman GH, Cairo MS. A phase I clinical, pharmacological, and biological trial of interleukim 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities. Clin Cancer Res. 2001 Jan;7(1):58-67. 6. Loh K, Matthay KK, Hoover M, Bracho FA, Cortez AB, Conte FA, Albanese CT, Miller TR, Price DC, Vlores AJ, Kaviani A, Shoback D. Hypercalcemia in malignant paraganglioma due to parathyroid hormone related protein. Horm Res. 1998;50(4):217-21. 7. Bracho F, Goldman S, Cairo MD. Potential use of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in neonates. Curr Opin Hematol. 1998 May; 5(3):215-20. Review. 8. Koo CH, Shin SS, Bracho F, Johnston WH, Rappaport H. Rosette-forming nonHodgkin’s lymphomas. Histopathology. 1996 Dec;29(6):557-63