Download Guidance Note 18 - Therapeutic Drug Monitoring information

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project

Document related concepts
no text concepts found
Transcript 
CLINICAL BIOCHEMISTRY
Guidance Note # 18
Document CI-CB-337-GN18 (TDM) Version 4
Reviewed biennially. Last review August 2015
Prepared by: Dr Anne Dawnay, Consultant Biochemist
Authorised by: Dr Anne Dawnay, Consultant Biochemist
Therapeutic Drug Monitoring information
All tests available 24/7 except cyclosporin, methotrexate and tacrolimus that are batched for analysis as indicated.
Test
Carbamazepine
Ciclosporin
Digoxin
Sample
Container
Gold top tube
Serum
Lavender top
tube
EDTA whole
blood
Gold top tube
Serum
Therapeutic range
4-12 mg/L
Oral: Ideal sampling time is pre-dose.
Dependent on patient type, dose
route and clinical application.
Oral or iv bolus: Ideal sampling time is
pre-dose. Same day service if received
by 11.00 Monday to Friday and by
08.00 Saturday. No Sunday service.
Oral: Ideal sampling time pre-dose or
at least 6-8 hours post administration
of dose.
Oral: Ideal sampling time is 12 hours
post administration of dose
0.9-2.0 μg/L dependent on clinical
application (0.5-1.0 μg/L in heart
failure)
0.6 - 1.0mmol/L (at lower end for
maintenance therapy and the
elderly)
Dependent on patient type and
dose route.
Lithium
Gold top tube
Serum
Methotrexate
Gold top tube
Serum
Phenobarbitone
Gold top tube
Serum
Gold top tube
Serum
10-40 mg/L
Tacrolimus
Lavender top
tube
EDTA whole
blood
Dependent on clinical application
Theophylline
Gold top tube
Serum
<1 month of age 5.0-13.0 mg/L
>1 month of age 10.0-20.0 mg/L
Valproate
Gold top tube
Serum
less than 100 mg/L
Phenytoin
Information
10-20 mg/L
Sampling time determined by protocol.
Daily service, including Saturday and
Sunday, sample must be received by
2pm.
Oral: Ideal sample time is pre-dose
Ideal sampling time:
Oral: For query adequate therapy the
pre-dose level is most useful.
Oral: For query intoxication a 4-5 hour
post dose level is most useful.
Ideal sampling time:
Pre-dose (trough level)
Not valid during IV infusion
Same day service if received by 10.00
on weekdays and Sunday. No
Saturday service.
Ideal sampling time:
Oral - Rapid release: 2 – 4 hours after
dose administration
Oral - Slow release: 3 - 5 hours after
dose administration
Oral; Ideal sampling time is pre-dose
For further information about this leaflet, or any other aspect of the Clinical Biochemistry
service, please telephone our HelpDesk. 020344 79405; (UCLH, Ext 79405)
Related documents