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TGFβ-Receptor 1/ALK5
NEIL MEHTA
BIOL 445.001
http://www.bcm.edu/pediatrics/cardiology/TGFBR2
http://en.wikipedia.org/wiki/TGF_beta_receptor_1
CELL SIGNALING PATHWAYS
HETERO-TETRAMERIC RECEPTOR COMPLEX FORMS
UPON BINDING TO LIGAND (TGFβ)
http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway
SARA MEDIATES RECEPTOR INTERNALIZATION
AND PHOSPHORYLATION OF SMAD2 (R-SMAD)
http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway
PHOSPOHRYLATED R-SMAD/SMAD4 ENTERS NUCLEUS
AND CAUSES TRANSCRIPTION OF DNA
http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway
TGFβ-RECEPTOR 1 INDUCES EPITHELIAL TO MESENCHYMAL
TRANSITION (EMT)
Valcourt et. al. Mol Biol Cell. 2005 April; 16(4): 1987–2002.
TβRI–/– MICE DIE AT MIDGESTATION DUE TO IMPAIRED YOLK SAC CIRCULATION
Larson et. al. EMBO J. 2001 April 2; 20(7): 1663–1673.
LOH OF TGF-βRI GENE IN PANCREATIC AND
BILIARY CANCERS
Goggins et. al. Cancer Res 1998;58:5329-5332
TREATMENT FOR PANCREATIC CANCER USING A TGFβR-1 INHIBITOR
Gaspar et. al. Molecular Pharmacology 2007: (72), 152–161.
ROLE OF TGFβ-RECEPTOR I IN OTHER
PATHWAYS
Lee et. al. EMBO J 2007, 26:3957-3967.
REFERENCES
Gaspar, Nicholas J., et al. (2007) Inhibition of Transforming Growth Factor β Signaling
Reduces Pancreatic Adenocarcinoma Growth and Invasiveness. Molecular
Pharmacology, 72(1): 152-161.
Goggins, Michael, et al. (1998) Genetic Alterations of the Transforming Growth Factor
β Receptor Genes in Pancreatic and Biliary Adenocarcinomas. Cancer Research, 58:
5329-5332.
Larsson, Jonas, et al. (2001) Abnormal angiogenesis but intact hematopoietic potential
in TGF-β type I receptor-deficient mice. The Embo Journal, 20(7): 1663-1673.
Lee, Matt K., et al. (2007) TGF-β activates Erk MAP kinase signaling through direct
phosphorylation of ShcA. The Embo Journal, 26(17): 3957–3967.
Massague, Joan S. (1998) TGFβ Signal Transduction. Annual Review of Biochemistry,
67: 753-791.
Valcourt, Ulrich. (2005) TGF-β and the Smad Signaling Pathway Support Transcriptomic
Reprogramming during Epithelial-Mesenchymal Cell Transition. Molecular Biology
of the Cell, 16(4): 1987–2002.
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