Download works of graduate student 2

Chemical biology approaches to investigate neuronal
ion channel function and disease mechanism
A
B
Yu et al. J Biol Chem (2011)
Li et al. J Biol Chem (2011)
C
&
Paw licking time (s)
250
Yu et al. Neuron (2010)
Highlighted by Previews in Neuron (2010)
Highlighted by News in Nature China (2010)
Li et al. Mol Pain (2011)
Duan et al. J Neurosci (2011)
Li & Xu. ACS Chem Neurosci (2011)
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200
150
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Saline
GMQ (100 M)
GMQ-Br (100 M)
GBO (10 mM)
AGM (10 mM)
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100
50
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0
asic3
+/+
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asic3
-/-
Methods, technology, and paradigms
Genetic/Chemical
Chemical biology
Covalent probes (pH 7.4)
E79C
0
DTNP
Amplitude (pA)
DTDP
-2000
DTDC
-4000
-6000
DTNB
-8000
0
120
240
360
480
600
Time (s)
Zhang et al. PLoS One (2008)
Physiology/Behavior
Yu et al. Neuron (2011)
Disease mechanisms
Duan et al. J Neurosci (2011)
Structural/Computational
Protein science