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Chemical biology approaches to investigate neuronal ion channel function and disease mechanism A B Yu et al. J Biol Chem (2011) Li et al. J Biol Chem (2011) C & Paw licking time (s) 250 Yu et al. Neuron (2010) Highlighted by Previews in Neuron (2010) Highlighted by News in Nature China (2010) Li et al. Mol Pain (2011) Duan et al. J Neurosci (2011) Li & Xu. ACS Chem Neurosci (2011) ** 200 150 ** Saline GMQ (100 M) GMQ-Br (100 M) GBO (10 mM) AGM (10 mM) ** 100 50 ## 0 asic3 +/+ ## ## asic3 -/- Methods, technology, and paradigms Genetic/Chemical Chemical biology Covalent probes (pH 7.4) E79C 0 DTNP Amplitude (pA) DTDP -2000 DTDC -4000 -6000 DTNB -8000 0 120 240 360 480 600 Time (s) Zhang et al. PLoS One (2008) Physiology/Behavior Yu et al. Neuron (2011) Disease mechanisms Duan et al. J Neurosci (2011) Structural/Computational Protein science