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Ciência sem Fronteiras (Science Without Borders) PhD Project Template: PI name & contact details: Department Professor Phil Jakeman [email protected] +353(0)61202800 Physical Education and Sport Sciences Faculty of Education and Health Sciences Has project been agreed with head (or nominee) of proposed registration school? Research Centre / group affiliation: Research group / centre website: Human Science Research Unit Centre for Intervention in Infection, Inflammation and Immunity www.ul.ie/4i and www.ul.ie/altitude PI website / link to CV: http://www.ul.ie/4i/content/prof-philip-jakeman Brief summary of PI research / research group / centre activity (2 or 3 lines max): The Altitude Research Group (www.ul.ie/altitude) seek to explore the physiological adaptation to short-term and prolonged exposure to altitude (normobaric hypoxia). Research is conducted within the newly constructed Altitude Centre and spans across areas of sports physiology (e.g. altitude training), clinical (e.g. habilitation/rehabilitation) and occupation medicine (e.g. flight crew performance). Title & brief description of PhD project (suitable for publication on web): Title: The effect of intermittent high intensity exercise in hypoxia on skeletal muscle metabolism and exercise performance. Brief Description: Altitude training is a widely-practiced component of elite athlete training for enhanced endurance performance. This project with challenge the current Live High Train Low (LHTL) paradigm of altitude training. Working in the newly commissioned Residential Altitude Centre the research will undertake to contrast the HDHL paradigm against a high intensity intermittent hypoxia programme specifically designed for endurance based sports that require repeated sprint ability. In addition to the cardiovascular and oxygen carrying capacity (e.g. total Hb mass) changes in peripheral muscle metabolism will be measured using in vivo microdialysis of skeletal muscle tissue challenged to exercise in normoxic and hypoxic environment. Unique selling points of PhD project in UL: Structured PhD Programme. Critical Mass of PIs and Interdisciplinary Researchers with recurrent Funded Research Grant Programme and Publication Output. Excellent Resources including a newly commissioned residential Altitude Centre. Superb campus environment. Name & contact details for project queries, if different from PI named above: Please indicate the graduates of which disciplines that should apply: Biological Sciences, Physiology, Biochemistry, Life Sciences, Sport and Exercise Sciences Please indicate whether students can apply for: Sandwich programme only Full PhD programme only √ Either of the above Ciência sem Fronteiras / Science Without Borders Priority Area: Please indicate the specific programme priority area under which the proposed PhD project fits- choose only one (tick box): Engineering and other technological areas Pure and Natural Sciences (e.g. mathematics, physics, chemistry) Health and Biomedical Sciences √ Information and Communication Technologies (ICTs) Aerospace Pharmaceuticals Oil, Gas and Coal Renewable Energy Minerals Biotechnology Nanotechnology and New Materials Technology of prevention and remediation of natural disasters Biodiversity and Bioprospection Marine Sciences Creative Industry New technologies in constructive engineering