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Transcript 
Physics of charged particle therapy
lecture #8
26 June 2017
[email protected]
Treatment planning tutorial
• Monday, XX July 2017 (not next week)
• 4.15pm
• Room H1.00.028
• Ground floor, behind reception desk
• Please have a working Matlab installation on your laptop
https://public.urz.uni-heidelberg.de/service-katalog/software/lizenzen/matlab.html
x
An experiment with a spread-out Bragg peak: setup
Gerwick & Paganetti: Radiobiology of charged particles https://radiologykey.com/radiobiology-of-charged-particles/
An experiment with a spread-out Bragg peak: setup
Gerwick & Paganetti: Radiobiology of charged particles https://radiologykey.com/radiobiology-of-charged-particles/
Cell survival curves for different C12 energies and cell lines
K. Weyrather, S. Ritter, M. Scholz, G. Kraft, W. "RBE for carbon track-segment irradiation in cell lines of differing repair capacity." International journal of radiation biology 75.11 (1999): 1357-1364.
Cell survival curves for different particles
Maeda, Junko, Ian M. Cartwright, Jeremy S. Haskins, Yoshihiro Fujii, Hiroshi Fujisawa, Hirokazu Hirakawa, Mitsuru Uesaka et al. "Relative biological effectiveness in canine osteosarcoma cells
irradiated with accelerated charged particles." Oncology letters 12, no. 2 (2016): 1597-1601.
Track structure
Scholz, Michael. "Effects of ion radiation on cells and tissues." Radiation effects on polymers for biological use (2003): 95-155.
Track structure
Scholz, Michael. "Effects of ion radiation on cells and tissues." Radiation
effects on polymers for biological use (2003): 95-155.
Track structure
Jakob, B., M. Scholz, and G. Taucher-Scholz. "Biological imaging of heavy charged-particle
tracks." Radiation research 159.5 (2003): 676-684.
JJ Wilkens: Evaluation of Radiobiological Effects in Intensity Modulated Proton Therapy : New Strategies for Inverse Treatment Planning 2004 Universitätsbibliothek Heidelberg
JJ Wilkens: Evaluation of Radiobiological Effects in Intensity Modulated Proton Therapy : New Strategies for Inverse Treatment Planning 2004 Universitätsbibliothek Heidelberg
M Frese: Potentials and risks of advanced radiobiological treatment planning for proton and carbon ion therapy 2011 Universitätsbibliothek Heidelberg
M Frese: Potentials and risks of advanced radiobiological treatment planning for proton and carbon ion therapy 2011 Universitätsbibliothek Heidelberg
RBE vs. LET for different ion species
M Scholz: Radiation quality in ion beam therapy: How to take into account variable RBE? @ EURADOS Winter school 2014 http://www.eurados.org//media/Files/Eurados/actions/7thwinterschool/5_Scholz-Michael_Radiation-Quality-in-Ion-Beam-Therapy-How-to-take-into-account-the-RBE.pdf
M Frese: Potentials and risks of advanced radiobiological treatment planning for proton and carbon ion therapy 2011 Universitätsbibliothek Heidelberg
Oxygen enhancement ratio
Wenzl, Tatiana, and Jan J. Wilkens. "Modelling of the oxygen enhancement ratio for ion beam radiation therapy." Physics in medicine and biology 56, no. 11 (2011): 3251.
Dose response variability
Glowa, Christin, Christian P. Karger, Stephan Brons, Dawen Zhao, Ralph P. Mason, Peter E. Huber, Jürgen Debus, and Peter Peschke. "Carbon ion radiotherapy decreases
the impact of tumor heterogeneity on radiation response in experimental prostate tumors." Cancer letters 378, no. 2 (2016): 97-103.
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