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Upregulation of K2P3.1 K+ Current Causes Action Potential
Shortening in Patients With Chronic Atrial
FibrillationCLINICAL PERSPECTIVE
by Constanze Schmidt, Felix Wiedmann, Niels Voigt, Xiao-Bo Zhou, Jordi Heijman,
Siegfried Lang, Virginia Albert, Stefan Kallenberger, Arjang Ruhparwar, Gábor
Szabó, Klaus Kallenbach, Matthias Karck, Martin Borggrefe, Peter Biliczki, Joachim
R. Ehrlich, István Baczkó, Patrick Lugenbiel, Patrick A. Schweizer, Birgit C. Donner,
Hugo A. Katus, Dobromir Dobrev, and Dierk Thomas
Circulation
Volume 132(2):82-92
July 14, 2015
Copyright © American Heart Association, Inc. All rights reserved.
Cardiac expression and remodeling of K2P channel mRNA in patients with sinus rhythm (SR),
paroxysmal atrial fibrillation (pAF), and chronic atrial fibrillation (cAF).
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
Atrial expression profile of indicated ion channel subunits in patients with sinus rhythm (SR),
paroxysmal atrial fibrillation (pAF), and chronic atrial fibrillation (cAF).
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
Western blot analysis of K2P3.1 protein in human right atrium.
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
K2P3.1 current properties in sinus rhythm (SR), paroxysmal atrial fibrillation (pAF), and chronic
atrial fibrillation (cAF).
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
Characteristics of action potentials (APs) and electropharmacological effects of K2P3.1 current
blockade in right atrial myocytes.
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
Computational analysis of the impact of K2P3.1 channels on action potential duration (APD).
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
Correlation of right atrial K2P3.1 mRNA levels with cardiac function.
Constanze Schmidt et al. Circulation. 2015;132:82-92
Copyright © American Heart Association, Inc. All rights reserved.
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