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Supplemental Table S4. Individual metabolite LC-MS geometric mean peak areas by season of blood drawa Percentage difference in peak area Peak area for Metabolite category Metabolite May-Jul vs FebAug-Oct vs FebNov-Jan vs Feb-Apr Feb-Apr Apr Apr Amines acetylcarnitine 6242155.4 0.8 4.0 2.4 Amines betaine 7151050.9 9.5 12.1 3.0 Amines carnitine 4288671.2 -1.2 2.2 -2.0 Amines putrescine 55536.1 -13.4 -13.9 -6.8 Amines trimethylamine-N-oxide 159181.5 -8.0 3.7 -15.8 Amino acid derivatives ADMA/SDMA 362870.2 1.3 6.2 -0.6 Amino acid derivatives aminoisobutyric acid 16459.9 -2.4 -7.4 -10.7 Amino acid derivatives anthranilic acid 2781.9 3.4 6.9 -7.0 Amino acid derivatives dimethylglycine 121623.2 6.0 14.0 -1.5 Amino acid derivatives indoxylsulfate 3432485.4 -10.0 6.3 -7.3 Amino acid derivatives kynurenic acid 8425.9 -0.9 7.6 -9.9 Amino acid derivatives kynurenine 568784.6 3.3 3.3 0.5 Amino acid derivatives NMMA 36464.8 5.0 5.6 -5.2 Amino acid derivatives quinolinate 295506.2 11.3 14.6 -4.4 Amino acid derivatives thyroxine 4867.9 1.9 3.4 3.1 Amino acid derivatives 2-aminoadipate 40505.2 2.5 1.6 -4.6 Amino acid derivatives 3-hydroxyanthranilic acid 4004.1 3.2 7.7 4.2 Amino acid derivatives xanthurenate 40856.4 -2.1 4.1 -0.3 Amino acids acetylglycine 24184 11.7 10.4 8.5 Amino acids alanine 1153662.1 -0.1 3.2 -4.9 Amino acids arginine 537313.3 -20.9 -21.4 5.5 Amino acids asparagine 160438.1 3.4 3.9 -3.2 Amino acids aspartate 10590 4.3 5.6 -3.5 Amino acids butyrobetaine 514949.9 0.0 9.7 -2.6 Amino acids cis/trans hydroxyproline 95224.8 -2.1 8.0 1.6 Amino acids citrulline 153445.3 5.2 6.6 2.2 Amino acids glutamate 238414.5 24.8 25.4 -1.8 Amino acids glutamine 4616874.1 -2.6 -1.7 -0.9 Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Amino acids Bile acids Bile acids Bile acids Bile acids Bile acids Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites glycine histidine isoleucine leucine lysine methionine methionine sulfoxide N-carbamoyl-beta-alanine ornithine phenylalanine pipecolic acid proline pyroglutamic acid serine threonine tryptophan tyrosine valine chenodeoxycholate/deoxycholate glycocholate glycodeoxycholate/ glycochenodeoxycholate taurocholate taurodeoxycholate/ taurochenodeoxycholate C14:0 LPC C14:0 SM C16:0 LPC C16:0 SM C16:1 CE C16:1 LPC C16:1 SM 16645.3 1791809.3 2236143.5 3309511.8 2858016.7 169263.7 5015.2 8663.4 865755.5 4433086.8 66318.4 7932779.5 62267.5 362700.6 523706.1 198998.2 35163.7 3718340 329867.2 161423.5 244902.6 4.2 4.8 1.2 -0.5 -0.4 -2.7 10.3 4.0 19.0 1.0 3.6 1.7 23.2 3.9 -3.4 0.4 1.6 0.2 0.2 8.6 27.2 6.3 8.5 3.2 3.9 -0.8 0.1 17.6 8.1 23.9 3.9 5.1 5.3 28.4 5.4 1.1 1.1 5.3 2.5 47.6 21.2 53.7 0.1 2.0 -5.9 -6.4 -3.9 -4.9 0.5 -4.0 -3.1 -3.6 2.6 -0.5 -10.6 -5.3 -8.9 0.0 -5.8 -4.7 30.2 0.5 15.0 27808.4 72654.5 15.0 13.7 27.8 45.7 -6.6 2.5 43278605.5 293184806.4 1665398361 1047473673 43336124.5 113676370.3 403435555.5 5.5 -0.7 2.9 -0.8 -1.6 2.9 -4.1 1.8 1.4 2.0 0.3 1.7 2.9 -2.6 -3.3 5.0 -1.8 1.3 -3.3 -3.0 1.9 Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites C18:0 CE C18:0 LPC C18:0 LPE C18:0 SM C18:1 LPC C18:1 SM C18:2 CE C18:2 LPC C18:2 SM C18:3 CE C20:3 CE C20:3 LPC C20:4 CE C20:4 LPC C20:5 CE C20:5 LPC C22:0 SM C22:6 CE C22:6 LPC C22:6 LPE C24:1 SM C32:0 PC C32:1 PC C32:2 PC C34:1 DAG C34:1 PC C34:2 DAG C34:2 PC C34:3 PC C34:4 PC C36:1 DAG C36:1 PC 144200348.5 898060412.2 28600150.6 220818112.8 684791226.6 150657455.2 1071030935 751600378.3 13184913.3 146445030.1 89974397.3 304870481.8 426789510.4 394886080.1 87704917.5 10854709.2 1682795578 52437119.2 69041137.7 281349793.8 224672132.4 179739064.4 227491428.4 108148781.3 28674668.9 1174763392 18819765.2 1429481989 350034724.6 66193484.1 22824700.5 486145600.8 -1.9 5.1 6.5 -4.0 2.5 -5.3 0.9 1.0 -3.0 1.5 -4.4 5.0 -0.4 2.3 -1.0 1.0 -1.0 -0.5 -1.3 6.0 -3.2 -4.6 -6.4 -4.7 5.0 -1.6 6.0 -3.6 -3.4 -5.6 0.5 -0.3 -2.7 3.6 7.4 0.1 2.3 -2.5 2.6 0.6 -1.7 6.1 -0.7 3.9 4.8 1.8 6.3 5.6 -0.5 9.8 0.4 4.4 -0.2 -2.3 -3.8 -2.3 -3.5 -0.3 -6.1 -3.3 -2.9 -3.1 -8.0 2.9 4.0 -0.3 2.5 2.1 0.4 1.0 -0.3 2.5 1.0 -1.6 0.2 1.5 1.1 0.4 -7.4 3.7 0.1 -1.4 -2.0 0.5 1.6 -1.5 -3.0 1.2 -8.6 -0.3 -6.2 -1.7 0.1 -0.8 -5.0 0.9 Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites C36:2 DAG C36:2 PC C36:3 PC C36:4 PC-A C36:4 PC-B C38:2 PC C38:3 PC C38:4 PC C38:5 PC C38:6 PC C40:6 PC C46:1 TAG C46:2 TAG C48:0 TAG C48:1 TAG C48:2 TAG C48:3 TAG C48:4 TAG C50:0 TAG C50:1 TAG C50:2 TAG C50:3 TAG C50:4 TAG C50:5 TAG C52:1 TAG C52:2 TAG C52:3 TAG C52:4 TAG C52:5 TAG C52:6 TAG C54:2 TAG C54:3 TAG 51621460.4 1283146029 1155385005 374732406.1 1208274356 205078296.7 350889685.1 881349728.3 715919833 729090826.6 299793982.8 50661791.6 40499795.5 34464297.5 161374005.4 180783618.1 102932155.6 99787414.9 42456275.8 250478426.5 446906814.7 421411886.8 213971805.8 105513155.3 201399077.9 568933753.3 852504286.7 782090435.9 373735014.5 95681830.4 158703985.2 231709729.3 -1.4 -1.9 -4.6 -2.5 -1.4 -1.3 -2.2 -2.3 -3.7 -3.3 -2.3 -5.1 -2.9 -4.7 -3.4 -2.9 -3.9 -7.4 -2.9 -0.4 -1.2 -2.0 -2.4 -4.8 -2.0 0.5 0.4 -0.3 0.1 -1.6 0.7 -1.7 -8.3 -3.2 -2.6 -3.2 -1.1 0.7 1.3 -1.8 -3.8 -3.1 -0.9 -4.0 2.4 -3.8 -3.6 -7.7 -10.0 0.0 -7.0 -4.0 -3.1 -8.4 -14.1 -9.9 -6.3 -2.8 -1.6 -7.5 -13.3 -12.7 -4.9 -8.8 -4.8 -0.3 -2.8 -2.1 0.3 -3.8 -0.3 -0.1 0.7 -3.9 -3.5 -6.0 -0.3 -12.2 -6.4 -5.4 -2.8 2.8 -12.9 -7.6 -3.8 -3.0 -4.1 -7.6 -8.1 -3.0 -0.9 -0.9 -2.9 -8.9 -2.2 -2.7 Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Lipids and lipid metabolites Organic acids Organic acids Organic acids Organic acids Organic acids Organic acids Organic acids Organic acids Organic acids Organic acids Organic acids Purines and pyrimidines Purines and pyrimidines Purines and pyrimidines C54:4 TAG C54:5 TAG C54:6 TAG C54:7 TAG C54:8 TAG C56:2 TAG C56:3 TAG C56:4 TAG C56:5 TAG C56:6 TAG C56:7 TAG C56:8 TAG C56:9 TAG C58:10 TAG C58:7 TAG C58:8 TAG C58:9 TAG aconitate alpha-hydroxybutyrate beta-hydroxybutyrate citrate fumarate/maleate/alphaketoisovalerate isocitrate lactate malate methylmalonate 2-hydroxyglutarate 3-methyladipate/pimelate urate uridine 1-methylnicotinamide 357719886.8 430078905.7 318761085.4 187502547.7 70833369.3 24961752.6 16135488.8 28806682.1 54836680.1 130755849.3 176741419.9 135146879.4 51248372.1 23064241.4 19576298 29590758.8 31388994.1 567636.2 579161.2 221880.9 24649850.5 575712.3 2.5 1.9 2.0 -6.4 -0.5 0.7 -10.1 -0.8 3.4 -1.3 -1.9 -2.8 0.2 4.6 1.0 -3.4 -1.8 5.4 -5.0 9.3 2.5 34.4 -2.9 -5.8 -11.3 -15.7 -10.2 -2.4 -18.6 -8.4 -8.6 -3.9 -6.1 -9.5 -5.2 1.6 2.9 -3.9 -5.4 5.6 -5.2 0.1 3.5 30.4 1.1 2.1 0.3 -11.3 -7.4 2.4 -13.4 -2.5 -1.8 -1.6 -1.2 -4.4 -3.2 0.8 -0.2 -1.3 -4.4 -1.9 -0.1 8.2 3.9 9.5 963125.4 31631267.4 2327998.9 525513 369740.2 38935.5 51859867.1 8555420.3 88399.3 4.3 17.7 41.5 5.3 37.3 -0.6 0.5 8.4 5.9 6.2 26.4 44.0 16.0 35.0 4.8 0.5 10.9 20.4 -1.9 -1.1 7.6 -0.1 20.6 -2.9 -0.4 3.1 8.7 Vitamins Vitamins Vitamins Other Other Other Other Other Other Other Other Other Other a pantothenate thiamine 4-pyridoxate allantoin cotinine creatine creatinine hippurate hydroxyphenylacetate phenylethylamine salicylurate sorbitol uracil 2043624.6 11342.4 484009.4 7109.5 6282.4 1248807.1 1457919.9 1999178.4 48734.1 282.8 1571183.7 3839645.9 623820.2 Geometric means were adjusted for the same variables as Supplemental Table S1. 3.9 15.4 16.9 17.0 24.7 5.5 0.9 -22.1 0.0 17.8 -31.5 3.0 7.9 -5.0 12.3 7.6 11.6 2.3 5.8 5.8 -5.1 -2.7 27.6 -3.7 3.9 7.9 2.7 -1.1 27.3 -13 -21.3 -8.2 0.2 -3.9 4.8 -0.1 -12.3 3.1 1.4