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Figure 1 A schematic diagram that illustrates the steps involved in content generation, processing and data analysis for antigen microarrays Modified with permission from Macmillan Publishers Ltd. Nat Biotechnol © (2003) 13 Robinson WH et al. (2003) Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol 21: 1033–1039 Sharp V and Utz PJ (2007) Technology Insight: can autoantibody profiling improve clinical practice? Nat Clin Pract Rheumatol 3: 96–103 doi:10.1038/ncprheum0404