Download Enz18 signal transduction

cAMP Controls Activity of Protein Kinase A
A
A
A
Active kinase
cAMP
A
R
R
C
A
C
A
A
Catalytic
subunits
Nucleus
R
R
C
CREB
P
CREB
DNA
A
C
Activation
C
Gene
expression
ON
Alberts et al (2002) Molecular Biology of the Cell (4e) p. 857, 858
Regulatory
subunits
cAMP Is the Second Messenger
Sutherland (1971)
Adenylate cyclase
結環脢 G protein
ATP
蛋白質激脢
Glucagon
Receptor
cAMP
A
G protein
Cyclic AMP (second messenger)
蛋白質激脢
Protein kinase A
Cascade
肝糖磷解脢激脢
肝糖磷解脢激脢
P
肝糖磷解脢 b
inactive
Active
肝糖磷解脢 a
P
Glycogen phosphorylase
Glycogen
肝糖
Glc-1-P
Juang RH (2007) BCbasics
Glycogen phosphorylase kinase
The Reception and Transduction of Signals
Gilman, Rodbell (1994)
Adenylate cyclase
a
a
GTP
GTP
G-protein-linked Receptor
Glucagon
+ Signal
-GDP
+GTP
a
g
b
GDP
a
GDP
b
g
G protein
Glycogen breakdown
A
The third group:
Ion-channel-linked Receptor
active
Glycogen
Synthase
P
P
+ Signal
Activation P
Protein
Phosphatase
Glycogen
P
kinase
P
P
SH2
domain
b
Juang RH (2007) BCbasics
Glycogen
Synthase
Enzyme-linked Receptor
a
Insulin
Signal Transduction Network (Ras vs. P53)
Cell function are controlled by protein interactions
Signal
Receptor
Cell membrane
Cytosol
Ras
Regulator protein
Transcription
Effector
enzyme
Signal protein
Ribosome
Inhibitor
Apoptosis
Nucleus
P53
E2F
Transcription
factor
Target gene
mRNA
Transcription
mRNA
Cell division ON
Juang RH (2007) BCbasics
Phosphatase
GP kinase
GP b
Glucagon
GP kinase P
GP a
Glycogen synthase
Glycogen synthase
A
PKA
P
Glycogen
Protein phosphatase-1
Protein phosphatase-1 P
Protein phosphatase inhibitor-1
active
Protein phosphatase inhibitor-1
P
inactive
Adapted from Kleinsmith & Kish (1995) Principles of Cell and Molecular Biology (2e) p.217