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DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Etiology of cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis. DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Biology of tumor growth. • Kinetics of tumor cell growth. • Tumor angiogenesis. • Tumor progression and heterogeneity. • Tumor invasion and spread. DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Kinetics Of Tumor Cell Growth Doubling time : that of normal cells. Growth fraction : pool , rarely >20%. equal or more than cells in replicative Production vz loss : Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Angiogenesis Tumor-associated angiogenic factors : -bFGF , VEGF……etc. Macrophage derived growth factors: -TNF-α. Weak angiogenic inhibitors: -Angiostatin , thrombospondin ( p53 upregulated) . DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Kinetics Of Tumor Cell Growth Clinical implications: 1- cancer therapey: Targeting cycling cells. Effect of radiation & debulking. 2- latent period of tumors : Months to years. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR Tumor Progression and Heterogeneity. DEPARTMENT OF PATHOLOGY, KAUH DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Invasion and Spread. Methods of spread : - Direct. -Through blood vessels. -Through lymph vessels. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH DR OSAMA I NASSIF FRCPC Neoplasia VI CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Etiology of Cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens. Neoplasia VI Chemical Carcinogens DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI Chemical Carcinogens DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI Chemical Carcinogens DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemotherapy Induced Malignancies
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