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Endocardial Notch Signaling in Cardiac Development and Disease by Guillermo Luxán, Gaetano D’Amato, Donal MacGrogan, and José Luis de la Pompa Circulation Research Volume 118(1):e1-e18 January 8, 2016 Copyright © American Heart Association, Inc. All rights reserved. The Notch signaling pathway. Guillermo Luxán et al. Circ Res. 2016;118:e1-e18 Copyright © American Heart Association, Inc. All rights reserved. Key events in cardiac development. Guillermo Luxán et al. Circ Res. 2016;118:e1-e18 Copyright © American Heart Association, Inc. All rights reserved. Endocardial Notch activity during cardiac development. Guillermo Luxán et al. Circ Res. 2016;118:e1-e18 Copyright © American Heart Association, Inc. All rights reserved. Developmental processes in cardiac valve development. Guillermo Luxán et al. Circ Res. 2016;118:e1-e18 Copyright © American Heart Association, Inc. All rights reserved. Endocardial Notch signaling is essential for chamber development. Guillermo Luxán et al. Circ Res. 2016;118:e1-e18 Copyright © American Heart Association, Inc. All rights reserved.