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Notch signaling regulates the fate of cells in the developing cerebral cortex. Notch signaling has several roles in cell differentiation in the developing cerebral cortex. The activation of Notch signaling in glial progenitor cells results in the differentiation as astrocytes and inhibits differentiation as oligodendrocytes (left pathway). Notch signaling also inhibits progenitor cells from differentiating into neurons (right pathway). (Photo on left reproduced, with permission, from David H. Rowitch; middle photo reproduced, with permission, from Edward Nyatia and Dirk Michael Lang/SA Science Lens Competition(SAASTA); photo on right reproduced, with permission, from Masatoshi Takeichi, Riken Center for Developmental Biology. Source: Differentiation and Survival of Nerve Cells, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: http://mhmedical.com/ Accessed: August 10, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved