Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download Table S1.
Document related concepts
no text concepts found
Transcript
Table S1. List of Selected Genes Modulated by BMI1-supression in CaP Cells. Gene Symbol Downregulated Cyclin D1 Cdk4 Bcl-2 Akt-1 PI3K u-PA Erbb2 Src c-Myc c-Jun H-Ras VEGF MMP-9 NFB1 HIF-1 IGF1 IGF2 IL-2 GGT2 PKC PKC Fold Changes Function Potential implication in CaP pathogenesis 26.0 7.5 20.0 3.5 3.0 6.5 7.0 2.5 8.5 2.5 2.0 6.5 11.0 4.0 3.0 8.0 9.0 10.0 3.5 2.5 2.0 Cell cycle, cell growth and/or maintenance Regulation of cell cycle; protein Kinase activity Mitochondrial protein that blocks the apoptotic death Survival factors; suppress apoptosis Pro-survival factor Involved in degradation of the extracellular matrix Kinase activity, phosphorylation, receptor activity Regulation of cell growth and development Transcription factor Transcription factor Signal transduction Growth factor Endopeptidases degrades extracellular matrix Signal transduction, transcription factor Transcription factor Growth factor receptor binds insulin-like growth factors Growth factor receptor binds insulin-like growth factors Inflammation response, cell proliferation Glutathione homeostasis Cell signaling, phosphorylation Cell Signaling Cell proliferation Cell Proliferation Cell proliferation and chemoresistance Cell proliferation and chemoresistance Cell Proliferation Cell migration and proliferation Cell proliferation and tumorigenesis Cancer progression Cell proliferation and tumorigenesis Cell survival and tumorigenesis Tumorigenesis Promoting cell migration, and inhibiting apoptosis Metastasis Survival, invasion and chemoresistance Tumor angiogenesis Cell survival and tumorigenesis Tumorigenesis Inflammation, cell growth Tumorigenesis Cell growth Cell growth, tumorigenesis 22.0 9.0 10.0 3.0 4.0 2.5 2.0 Tumor suppressor, cell-cycle arrest in G1 & G2 phase Cell growth regulator, controls cell cycle Stem cell localization to the bone marrow Negatively regulating cell proliferation Calcium-dependent cell-cell adhesion Metalloendopeptidase inhibitor activity Sumoylation Proliferation inhibition Growth inhibition Proliferation inhibition Negative regulator of cell proliferation Invasion and metastasis inhibition Induces apoptosis, inhibits invasion Cytokine inhibitors, Inflammation inhibitors Upregulated p16/Ink4 p15 p57 CD164 Cadherin-9 TIMP-3 PIas2
Related documents