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From: Cysteine-rich 61, a Member of the CCN Family, as a Factor Involved in the Pathogenesis of Proliferative Diabetic
Retinopathy
Invest. Ophthalmol. Vis. Sci.. 2009;50(7):3447-3455. doi:10.1167/iovs.08-2603
Figure Legend:
Effect of Cyr61 on retina neovascularization in the OIR model of retinopathy. (A, B) Representative histopathological
pictures from OIR mice retinas. Intraocular injection of anti-mouse Cyr61 antibody (1 μL at 200 μg/mL), performed as
mice were returned to room air, significantly decreased retinal neovascularization (arrow) compared with equivalent
injection of control IgG in the contralateral eye at P19. (C) Anti-mouse Cyr61 treatment resulted in decreased nuclei
number in retinal endothelial cells, shown as mean ± SD of number of neovascular tufts in the retina (n = 10). (D–F)
Representative pictures of retinal immunohistochemistry in formalin-fixed, paraffin-embedded tissues. Mice with OIR
showed
slight Cyr61
staining in the nerve
fiber layer,for
the
outer plexiform
and the inner Copyright
nuclear layers,
asAllwell
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strong Cyr61 expression in vascular ECs in the sensory retina and in the neovascular vessels (arrow, D); IgG staining of