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SMALL INTESTINE DUODENUM JEJUNUM ILEUM SMALL INTESTINE • Serosa:Visceral peritoneum. • Muscularis externa:Thick inner and thin outer layer. • Sub mucosa:Brunner’s glands – in duodenum secretes fluid rich in bicarbonate. • Mucosa:• Villi: finger like projection. Duodenum– broad and ridge like. Jejunum –tall and leaf like. Ileum –short and finger like. • Valves of kerkring – large circular folds of mucosa. • Crypts of lieberkuhn – intestinal glands. • • • • Epithelium:1. Absorptive columnar cells or enterocytes. Each cell bears around 3,000 microvilli. 2. Goblet cell – mucous protects & lubricates intestinal wall. • Crypts of lieberkuhn (intestinal glands):• These are tubular pits opening in between the bases of villi. Types of cells in crypts:• Columnar cells:• Mucous (Goblet) cells:- • Paneth cells:Present in deeper part of intestinal glands. Rich in zinc and secretes lysozymes which is a antibacterial substance. • Stem cells: Undifferentiated mitotic cells. • Enteroendocrine cells: • • • • Pyramidal or columnar in shape with apical nuclei Infranuclear black granules that stain with silver salts. Also called argentaphil cells or enterochromaffin cells. Intestinal glands • Lamina propria: • Crypts of leiberkuhn in duodenum. • Contains Crypts of leiberkuhn and solitary lymphoid follicles in jejunum. • Peyers patches in ileum –10 to 250 lymphoid follicles DUODENUM JEJUNUM ILEUM Features Villi Duodenum Broad ridges Goblet cells Few Lamina Crypts of propria lieberkuhn Sub mucosa Brunner's glands Jejunum Tall foliate Few Crypts of lieberkuhn & diffuse lymphocytes Only connective tissue Ileum Short finger like More Crypts of lieberkuhn & Payers patches. Payers patches