Download Supplementary file S1. Sequences for ClustalO alignment of RXR

Supplementary file S1. Sequences for ClustalO alignment of RXR sequences from selected species
shown in Fig.1.
(in FASTA format)
>sp|P20153|USP_DROME Protein ultraspiracle OS=Drosophila melanogaster GN=usp PE=1 SV=1
-------------------------------------------------------------------------MDNCDQDASFRLSHIKEEVK-------PDISQLNDSNNSS--------------------FSPKAESPVPFMQAMSMVHVL-----------PGSNSA------SSNNNSAGDAQ-MAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHLCSICGDRASGKHYGVY
SCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQ
RGARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFS
IERIIEAEQRAETQCGDRALTFLRV-GPYSTVQPDYKGAVSALCQVVNKQLFQMVEYARM
MPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPG
LQPQQLFLNQSFSYHRNSAIKAGVSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNP
DIRGIKSRAEIEMCREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFL
FRITSDRPLEELFLEQLEAPPPPGLAMKLE
>tr|S5ZWR0|S5ZWR0_AURAU Retinoid X receptor OS=Aurelia aurita GN=RXR PE=2 SV=1
---------------MEISYCDST----------------------------------------------------TDR----------EELH--LP---EKVPGME------Y----A
CEE----------------------DGSSMNMVDSC-------LPEPPPLESI----DSY
SPLSGSDGTPGSSSS-------SLSFFPQNSSPNSNGSERQMLPCAVCSDKAYVKHYGVV
ACEGCKGFFKRSVRNNRKYQCLGNQRCDIDRKSRNKCQYCRFQKCIEVGMKPEAVQDETL
KKEKRESTKRKAANPVSSGSK---GSP-------------------VEVTSSRVEMPLVP
IDLVVSAESMVEPSIQ----LFA----------NTAVDPIRHVCLAADKQLASLAEWAKK
LPHFTSLDITDQVVLLQWSWPELLIGGFCHRSAAVR--------------------------DGILLATGLHLTRENLKKAGVGAIIDKIFAEVIEKMQEMQLDRAEWGCLRAVMLFSP
DAKNLKDVQQVETYREMYSATLEDYMKKNRPDQPDRFTKVILRVPALKSIGLQALEHLYF
FKLIGDVPMETFLLDMLEVTQP------->tr|O96562|O96562_TRICY Retinoic acid X receptor OS=Tripedalia cystophora PE=2 SV=1
---------------MA-VQCNSS------------------------------------
-----------------TANDVVSKEVSEETKLQ--IV---KEEETSAPSCDSSV----S
AMS----------------------KEGGLAMVDSC-------LKEASPLESI----HPY
SPLASDASGSSTSPI-------ASSSLLQ-LPSLTADSQRPVQPCSVCSDKAYVKHYGVF
ACEGCKGFFKRSVRNNRKYSCLGKRHCDTDKKSRNRCQYCRFQKCVQVGMKPEAVQDETL
KKERKDYRKRL-----PSTPK---GSP-------------------AEVTSSKVDLPMIP
IESIIAAETLVDPGIQ----TFA----------SANTDPIRHVCLAADKQLASLAEWAKR
LPHFRDLSIADQVVLLQWSWPELLIGGFCHRSCAVK--------------------------DGILLSTGLHLTRDNLKKAGVGAIIDKIFSEVIEKMQEIQMDRAEWGCLRAIMLFSP
DAKGLTAIDQVENYRELYTSTLEDHVKRKHPEQPDRFTKVILRIPALKSIGLQALEHLYF
FKLIGDVPMDTFLLDMLEVDRS------->TaRXR ID 53515
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDRSFKKEAQADKSNGNCLVCNDRASGRHYGVY
SCEGCKGFFKRTVRKNLTYTCRDNRNCDIDKKQRNRCQYCRYQKCLQVGMKQEAVQEERV
KNSTPTSKTTLPIAIAD-------G-----------------------FPLPTYGNDEMP
VEAIRDAESTLNMNSV----PYVEM----------QSNPVLNICQAADKQLFNLVEWAKK
IPHFCDLCVDDQVILLRSGWNELLIAAFSFRSIAVE--------------------------DGLLLSTGHYIHRTSAHNAGIGAIFDRILTELVNQMRYLKMDKTELGCLRAIILFNP
DVRGLTSADRVEKYRELVYGALEAYVKKRFPDQLCRFAKLLLRLPALRAISLKTLEHLFF
YKLIGDPPIDTFLMEMLETGSS*------>sp|P28702|RXRB_HUMAN Retinoic acid receptor RXR-beta OS=Homo sapiens GN=RXRB PE=1 SV=2
MSWA--ARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQ
QTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLG-------GSGAPP-------PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQIN
STVSLPGGGSGPPEDVKPPVLGVRGL---HCPPPPGGPGAGKRLCAICGDRSSGKHYGVY
SCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQ
RGKDKDG-D---------------------------------------GEGAGGAPEEMP
VDRILEAELAVEQKSD----QGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKR
IPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVR--------------------------DGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP
DAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFF
FKLIGDTPIDTFLMEMLEAPHQLA----->sp|P48443|RXRG_HUMAN Retinoic acid receptor RXR-gamma OS=Homo sapiens GN=RXRG PE=1 SV=1
---------------------------------MYGNYSHFMKFPAGY--------GGS-------------------------------PGHTGS-------TSMSPSAALSTGKPMD
SHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQL
NVVNS----VSSSEDIKPL-PGLPGIGNMN-YPSTSPGSLVKHICAICGDRSSGKHYGVY
SCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQ
RSRERAESE---------------------------------------AECATSGHEDMP
VERILEAELAVEPKTE----SYGDM--NME---NSTNDPVTNICHAADKQLFTLVEWAKR
IPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQ--------------------------DGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP
DAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFF
FKLIGDTPIDTFLMEMLETPLQIT----->sp|P19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha OS=Homo sapiens GN=RXRA PE=1 SV=1
-----MDTKHFLP----------L--------------------------------DFST
QVNS----------------------S-LTSPTGRGS----MAAPSLHPSLGP----------GIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLS
SPMNP----VSSSEDIKPP-LGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVY
SCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQ
RGKDRNENE---------------------------------------VESTSSANEDMP
VERILEAELAVEPKTE----TYVEA--NMGLNPSSPNDPVTNICQAADKQLFTLVEWAKR
IPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVK--------------------------DGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP
DSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFF
FKLIGDTPIDTFLMEMLEAPHQMT------
>sp|P51128|RXRA_XENLA Retinoic acid receptor RXR-alpha OS=Xenopus laevis GN=rxra PE=1 SV=1
MSSAAMDTKHFLP----------LGGRT-----CADTLRCTTSWTAGY--------DFSS
QVNS----------------------SSLSSSGLRGS----MTAPLLHPSLGN------S
GLNNSLGSPTQLPSP---LSSPINGMGPPFSVISPPLGP-SMAIPSTPGLGYGTGSPQIH
SPMNS----VSSTEDIKPP-PGINGILKVPMHPSGAMASFTKHICAICGDRSSGKHYGVY
SCEGCKGFFKRTVRKDLTYTCRDSKDCMIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQ
RGKERNENE---------------------------------------VESSNSANEDMP
VEKILEAEHAVEPKTE----TYTEA--NMGLAPNSPSDPVTNICQAADKQLFTLVEWAKR
IPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVK--------------------------DGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP
DSKGLSNPLEVEALREKVYASLEAYCKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFF
FKLIGDTPIDTFLMEMLEAPHQMT------