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A dominant-negative mutant of C/EBPα, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse by Maike Schwieger, Jürgen Löhler, Meike Fischer, Uwe Herwig, Daniel G. Tenen, and Carol Stocking Blood Volume 103(7):2744-2752 April 1, 2004 ©2004 by American Society of Hematology Mut10 C/EBPα expresses enhanced levels of a 30-kDa protein. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology G-CSF stimulates the formation of CFU-G colonies in mut10-transduced BM cells but not in BM in which Cebpa has been excised. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology FMEV/mut10-infected cells still contain a high percentage of granulopoiesis after 14 days in culture. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology Mut10-expression alters the kinetics but does not block the differentiation of murine BM cells. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology Transduction of mut10 into human CD34+ CB cells abrogates myeloid differentiation. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology Impaired differentiation of human CD34+ progenitors expressing mut10 C/EBPα documented by flow cytometric profiles. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology Immunocytochemical demonstration of lineage-specific cell marker expression of infected cultures. Maike Schwieger et al. Blood 2004;103:2744-2752 ©2004 by American Society of Hematology
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