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Molecular characterization of additional resistant MB allografts reveals mechanisms of GDC0449 resistance downstream of SMO. A, quantification of Gli1 mRNA levels by qRT-PCR in expanded tumors (n = 3) collected 6 hours after a single dose with either vehic... Gerrit J. P. Dijkgraaf et al. Cancer Res 2011;71:435-444 ©2011 by American Association for Cancer Research