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Transcript 
Apolipoprotein E Enhances MicroRNA-146a in Monocytes
and Macrophages to Suppress Nuclear Factor-κB–Driven
Inflammation and AtherosclerosisNovelty and Significance
by Kang Li, Daniel Ching, Fu Sang Luk, and Robert L. Raffai
Circulation Research
Volume 117(1):e1-e11
June 19, 2015
Copyright © American Heart Association, Inc. All rights reserved.
Apolipoprotein E (ApoE) is primarily expressed in macrophages and monocytes and suppresses
nuclear factor-κB (NF-κB) inflammatory signaling in these cells.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
MiR-146a levels are reduced in apolipoprotein E (apoE)-deficient macrophages and monocytes,
but not other myeloid and lymphoid cells.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
Ectopic apolipoprotein E (apoE) expression enhances miR-146a expression in macrophages and
monocytes.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
Apolipoprotein E (ApoE) increases miR-146a transcription by enhancing transcription factor
purine-rich PU-box–binding protein 1 (PU.1).
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
Hyperlipidemic HypoE mice expressing reduced apolipoprotein E (apoE) levels display
enhanced miR-146a in macrophages and monocytes that suppress their cellular activation.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
In vivo delivery of miR-146a (146a-m) mimetics inhibits macrophage inflammatory responses,
Ly-6Chigh monocytosis and atherosclerosis in hyperlipidemic Apoe–/–Ldlr–/– mice.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
In vivo delivery of miR-146a mimetics (146a-m) reduces macrophage inflammatory responses,
Ly-6Chigh monocytosis, and atherosclerosis in Ldlr–/– mice fed a high-fat diet.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
Apolipoprotein E (ApoE) enhances purine-rich PU-box–binding protein 1 (PU.1)-dependent miR146a transcription to suppress nuclear factor-κB (NF-κB)−driven monocyte and macrophage
activation and thereby inflammation and atherosclerosis.
Kang Li et al. Circ Res. 2015;117:e1-e11
Copyright © American Heart Association, Inc. All rights reserved.
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