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Transcript 
In vivo inhibition by a site-specific catalytic RNA subunit of
RNase P designed against the BCR-ABL oncogenic
products: a novel approach for cancer treatment
by C. Cobaleda, and I. Sánchez-Garcı́a
Blood
Volume 95(3):731-737
February 1, 2000
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
Sequence-specific cleavage ofBCR-ABLp190 substrate by M1-p190-GS.Autoradiograph of
cleavage products generated by M1-GS constructs.BCR-ABLp190 substrate was incubated
either alone (lane 1), with M1-p190-GS (lane 2), with M1-p210-GS (lane 3), or with M1-TC-G...
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
Sequence-specific cleavage ofBCR-ABLp210 substrate by M1-p210-GS.Autoradiograph of
cleavage products generated by M1GS constructs.BCR-ABLp210 substrate was incubated either
alone (lane 1), with M1-p190-GS (lane 2), with M1-p210-GS (lane 3), or with M1-TC-GS...
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
Comparison of suppression ofBCR-ABLp190 mRNA transcripts.Direct comparison of
suppression ofBCR-ABLp190 mRNA transcripts in Ba/F3 + p190 cells transfected either with the
MFG-M1-p190-RNA vector or with the same vector carrying only theBCR-ABLp190 antisense ...
C. Cobaleda, and I. Sánchez-Garcı́a Blood 2000;95:731-737
©2000 by American Society of Hematology
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