Download JING CHEN - Tulane University

CURRICULUM VITAE
Jing Chen, MD, MMSc, MSc
Associate Professor of Medicine
Division of Nephrology and Hypertension
Department of Medicine
Tulane University School of Medicine
ADDRESS
Office Address
Division of Nephrology and Hypertension
Department of Medicine
Tulane University School of Medicine
1430 Tulane Avenue, SL 45
New Orleans, LA 70112
Home Address
3721 North LaBarre Road
Metairie, LA 70002
Office Tele
Fax
Mobile
E-mail
(504) 988–6110
(504) 988–7448
(504) 858-1596
[email protected]
CITIZENSHIP
United States
EDUCATION
Degrees
M.D., July 1984
Jiangxi Medical College
Jiangxi Province, PR China
Master of Medical Sciences, August 1989
Peking Union Medical College and Chinese Academy of Medical Sciences
Beijing, PR China
Master of Sciences (Biotechnology), May 1995
Johns Hopkins University
Baltimore, Maryland
Post-doctoral Training
1983-1984
Internship in Internal Medicine
1
Nanchang City Hospital
Jiangxi Province, PR China
1984-1986
Residency in Internal Medicine
Pingxiang City Hospital
Jiangxi Province, PR China
1986-1989
Clinical Fellow
Peking Union Medical College and Chinese Academy of Medical
Sciences
Beijing, PR China
1990-1992
Research Fellow
Department of Physiology and Pharmacology
Bowman Gray School of Medicine
Wake Forest University
Winston-Salem, NC
1998–2001
Internship and Residency in Internal Medicine
Department of Medicine
Tulane University School of Medicine
New Orleans, LA
2001-2003
Clinical Fellow in Nephrology
Division of Nephrology and Hypertension
Tulane University School of Medicine
New Orleans, LA
Certification
1996
2000
2001
2002
2003
2010
ECFMG Certificate
US National Broad of Medical Examiners
Louisiana Broad of Medical Examiners
American Broad of Internal Medicine
American Broad of Nephrology
Specialist in Clinical Hypertension
APPINTMENTS
1989-1990
Instructor in Medicine
Peking Union Medical College and Chinese Academy of Medical Sciences
Beijing, PR China
2003-2010
Assistant Professor of Medicine
Section of Nephrology and Hypertension
Department of Medicine
Tulane University School of Medicine
2
New Orleans, LA
2003-2010
Adjunct Assistant Professor of Epidemiology
Department of Epidemiology
Tulane University School of Public Health and Tropical Medicine
New Orleans, LA
2010-
Associate Professor of Medicine
Section of Nephrology and Hypertension
Department of Medicine
Tulane University School of Medicine
2010-
Adjunct Associate Professor of Epidemiology
Department of Epidemiology
Tulane University School of Public Health and Tropical Medicine
New Orleans, LA
RESEARCH INTEREST
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Etiology, Prevention and Treatment of Chronic Kidney Disease and Hypertension
Cardiovascular Disease in Chronic Kidney Disease
Metabolic Syndrome and Obesity Related Kidney Disease
Diabetic Nephropathy
Gene-Environment Interaction in Chronic Kidney Disease and Hypertension
HONOR AND AWARD
Jorgen U. Schlegel Award for Excellent in Research, Tulane University School of Medicine,
2003
BIRCWH (Interdisciplinary Research in Women’s Health) Scholarship funded by NIH, 20032005
Young Investigator Travel Awards, 2nd Biennial National IDeA Symposium of Biomedical
Research Excellence, NIH/NCRR, 2008
PROFESSIONAL MEMBERSHIP
Member of American Society of Nephrology
Member of American Medical Association
Member of American Heart Association
Member of American Diabetes Association
JOURNAL REVIEWS AND EDITORIAL BOARDS
3
American Journal of Kidney Disease
Diabetes Care
Journal of the American Society of Nephrology
DISSERTATION COMMITTEE MEMBER
Kristi Reynolds, MPH, Tulane University School of Public Health and Tropical Medicine
"A Prospective Cohort Study of Risk Factors for End-stage Renal Disease" (October, 2004)
Current Position: Research Scientist, Department of Research and Evaluation, Southern
California Permanente Medical Group, Pasadena, CA.
Tanika N. Kelly, MPH, Tulane University School of Public Health and Tropical Medicine
“Genetic Variants Associated with Salt Sensitivity of Blood Pressure: Candidate Gene Analysis
in the Genetic Epidemiology Network of Salt-Sensitivity” (November, 2008)
Current Position: Assistant Professor, Department of Epidemiology Tulane University School of
Public Health and Tropical Medicine, New Orleans, LA
4
CLINICAL SERVICES
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Inpatient nephrology consultation at Tulane University Hospital, VA Hospital, and
Charity Hospital
Inpatient nephrology services at Tulane University Hospital
Inpatient medicine ward services at Charity Hospital
Inpatient transplant nephrology services at Tulane University Hospital
Out-patient dialysis services at Tulane University Hospital and Westbank Dialysis Units
Kidney biopsy services at Tulane University Hospital, VA Hospital, and Charity Hospital
Out-patient nephrology clinics at Tulane University Hospital, VA Hospital, and Charity
Hospital
TEACHING
In Classes
Acid-Base and Electrolyte Cases (2005)
Acute Renal Failure and Chronic Kidney Disease Cases (2005)
Problem-Based Learning Exercise: Mechanisms of Disease-Kidney Block (2003-now)
In Hospitals
Bedside teaching to medical students, residents and nephrology fellows during rounds
Lecture
Disorders of Calcium, Phosphate and Vitamin D Metabolism in CKD (2008-now)
Grant Rounds
Medical School
The Metabolic Syndrome (May 2009)
Nephrology
Diabetic Nephropathy (November 2003)
Metabolic syndrome and CKD (May 2004 and March 2006)
Insulin resistance, obesity, metabolic syndrome and salt-sensitivity (January 2005)
Obesity, adipocytokines and CKD (March 2007)
Cold pressor test, kidney function, metabolic syndrome and salt-sensitivity of blood pressure
(December 2007)
Endothelial dysfunction and CKD (October 2006, February 2008, and June 2009)
Vascular calcification in CKD (March 2010)
Seminar
School of Public Health and Tropical Medicine
Endothelial dysfunction and CKD (November 2008)
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The Metabolic syndrome (November 2009)
Physiology
Endothelial dysfunction and CKD (October 2007)
Journal Club
Anti-glomerular basement membrane disease (February 2004)
Focal segmental glomerulosclerosis (March 2005)
IgA nephropathy (April 2005)
Assessment of kidney function (January 2006)
Update on the treatment of lupus nephritis (April 2007)
Vascular calcification in CKD (November 2007 and March 2008)
Accuracy in GFR estimates (January 2008)
Peripheral arterial disease in chronic kidney disease (August 2008)
Diabetic Nephropathy (January 2009)
Efficacy of combined use of aliskiren and ARB on proteinuria and blood pressure control
(February 2009)
Vitamin D therapy for patients with CKD (November 2009)
New Understanding on Blood Pressure and Lipid Control for Diabetic
Patients – the ACCORD Study(May 2010)
Case Presentation
Hypokalemia (December 2004 and November 2008)
Hypernatremia (May 2006)
Vasculitis (November 2009)
ADVISING/MENTORING
Saravanan Balamuthusamy (Nephrology fellow)
Alhakam Hudaihed (Nephrology fellow)
Enver Khan (Nephrology fellow)
Chad Miller (Resident)
Federico J Teran (Resident)
Kamal Shah (Medical student)
Joseph Tarsia (Medical student)
Stephanie Rogers (Medical student)
ADMINISTRATIVE SERVICE
Medical Director, Tulane University Office of Health Research (OHR). Tulane OHR is a
research clinic where several NIH-sponsored projects have been conducting at this facility since
2003.
PUBLICATIONS
6
1.
Chen J, Ching R-J. Study on ultrasonographic value in the evaluation of neonatal
intracranial hemorrhage and its complications. J Clinical Pediatrics (Chinese). 1990;
8:220-222.
2.
Chen J, Ching R-J. Normal value measurement of the brain ventricles by ultrasound in
0-18 month old infants. J Clinical Ultrasound (Chinese). 1990; 10:396-399.
3.
Busija DW, Chen J. Reversal by increased CFS [H+] and [K+] of phorbol ester induced
arteriolar constriction in piglets. Am J Physiology. 1992; 263: H1455-H1459.
4.
Busija DW, Chen J. Effects of trigeminal neurotransmitter on piglet pial arterioles. J Dev
Physiol. 1992; 18:67-72.
5.
Busija DW, Khreis LY, Chen J. Prostanoids promote arteriolar dilation and mask
arteriolar constriction to oxytocin in piglets. Am J Physiology. 1993; 264:H1023-H1027.
6.
Chen J, He J, Ogden LG, Batuman V, Whelton PK. Relationship of serum antioxidant
vitamins to serum creatinine in the US population. Am J Kidney Dis. 2002; 39:460-468.
7.
He J, Muntner P, Chen J, Roccella EJ, Streiffer RH, Whelton, PK. Factors associated
with hypertension control in the general population of the United States. Arch Intern
Med. 2002; 162:1051-1058.
8.
Chen J, He J, Hamm L, Batuman VB, Whelton PK. Serum antioxidant vitamins and
blood pressure in the US population. Hypertension. 2002; 40:810-816.
9.
Gu D, Reynolds K, Wu X, Chen J, Duan X, Muntner P, Huang G, Reynolds RF, Su S,
Whelton PK, He J. Prevalence, awareness, treatment and control of hypertension in
China. Hypertension. 2002; 40:920-927.
10.
Chen J, Muntner P, Hamm L, Fonseca V, Batuman V, Whelton PK, He J. Insulin
resistance and risk of chronic kidney disease in non-diabetic US adults. J Am Soci
Nephrol. 2003; 14:469-77.
11.
Reynolds K, Gu D, Muntner P, Wu X, Chen J, Huang G, Duan X, Whelton PK, He J.
InterASIA Collaborative Group. Geographic variations in the prevalence, awareness,
treatment and control of hypertension in China. J Hypertens. 2003; 21:1273-1281.
12.
Gu D, Reynolds K, Duan X, Xin X, Chen J, Wu X, Mo J, Whelton PK, He J for the
InterASIA Collaborative Group. Prevalence of diabetes and impaired fasting glucose in
Chinese adult population: International Collaborative Study of Cardiovascular Disease in
Asia (InterASIA). Diabetologia. 2003; 46:1190-1198.
13.
He J, Gu D, Reynolds K, Wu X, Muntner P, Zhao J, Chen J, Liu D, Mo J, Whelton PK
for the InterASIA Collaborative Group. Serum total and lipoprotein cholesterol levels and
awareness, treatment and control of hypercholesterolemia in China. Circulation. 2004;
110:405-411.
14.
Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J.
The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med.
2004; 140:167-74.
15.
Muntner P, He J, Chen J, Fonseca V, Whelton PK. Prevalence of non-traditional
cardiovascular disease risk factors among persons with impaired fasting glucose,
7
impaired glucose tolerance, diabetes, and the metabolic syndrome: analysis of the Third
National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol.
2004; 14:686-95.
16.
Chen J, Wildman RP, Hamm LL, Muntner P, Reynolds K, Whelton PK, and He J.
Association between Inflammation and Insulin Resistance in US Non-Diabetic Adults:
Results from NHANES III. Diabetes Care. 2004; 27:2960-2965.
17.
Muntner P, Hamm LL, Kusek J, Chen J, Whelton PK, He J. The prevalence of
nontraditional risk factors for coronary heart disease in patients with chronic kidney
disease. Ann Intern Med. 2004; 140:9-17.
18.
Gu DF, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, Whelton PK, He J.
Prevalence of the metabolic syndrome and overweight among adults in China. Lancet.
2005; 365:1398-405.
19.
He J, Gu D, Wu X, Duan X, Chen J, Chen J, Whelton PK. Effect of soybean protein on
blood pressure: A randomized controlled trial. Ann Intern Med. 2005; 143:1-9.
20.
Muntner P, Gu D, Wildman RP, Chen J, Qan W, Whelton PK, He J. Prevalence of
physical activity among Chinese adults: results from the International Collaborative
Study of Cardiovascular Disease in Asia. Am J Public Health. 2005; 95:1631-1636.
21.
Wildman RP, Gu D, Muntner P, Huang G, Chen J, Duan X, He J. Alcohol intake and
hypertension subtypes in Chinese men. J Hypertens. 2005; 23:737-743.
22.
Chen J, Wildman RP, Gu D, Kusek J, Spruill M, Reynolds K, Liu D, Whelton PK, He J.
Prevalence of decreased kidney function in Chinese adults aged 35-74 years. Kidney Int.
2005; 68:2837-2845.
23.
Muntner P, Gu D, Reynolds RF, Wu X, Chen J, Whelton PK, He J. Therapeutic lifestyle
changes and drug treatment for high blood cholesterol in China and application of the
Adult Treatment Panel III Guidelines. Am J Cardiol. 2005; 96:1260-5.
24.
He J, Gu D, Duan X, Reynolds K, Wu X, Chen C, Chen J, Wildman RP, Klag MJ,
Whelton PK. Major causes of death in China: A prospective study of 169,871 men and
women. N Engl J Med. 2005; 353:1124-34.
25.
Gu D, Gupta A, Muntner P, Hu S, Duan X, Chen J, Reynolds RF, Whelton PK, He J.
Prevalence of cardiovascular disease risk factor clustering among the adult population of
China: results from the International Collaborative Study of Cardiovascular Disease in
Asia (InterAsia). Circulation. 2005; 112:658-665.
26.
Muntner P, Wildman RP, Reynolds K, Desalvo KB, Chen J, Fonseca V. Relationship
between HbA1c level and peripheral arterial disease. Diabetes Care. 2005; 28:1981-7.
27.
Wildman RP, Muntner P, Chen J, Sutton-Tyrrell K, He J. Relation of inflammation to
peripheral arterial disease in the national health and nutrition examination survey, 19992002. Am J Cardiol. 2005; 96:1579-83.
28.
Chen J, He J, Wildman RP, Reynolds K, Streiffer RH, Whelton PK. A randomized
controlled trial of dietary fiber intake on serum lipids. Euro J Clin Nutr. 2006; 60:62-68.
8
29.
Gu D, He J, Wu X, Reynolds K, Huang G, Chen J, Duan X, Chen C-S, Whelton PK.
Body weight and mortality among men and women in China. JAMA. 2006; 295:776-83.
30.
Chen J, Gu D, Chen CS, Wu X, Hamm L, Muntner P, Batuman V, Lee C-H, Whelton
PK, He J. Association between the metabolic syndrome and chronic kidney disease in
Chinese adults. Nephrol Dial Transplant. 2007; 22:1100-1106.
31.
Yang W, Reynolds K, Gu D, Chen J, He J. A comparison of two proposed definitions for
metabolic syndrome in the Chinese adult population. Am J Med Sci. 2007; 334:184-9.
32.
Reynolds K, Gu D, Muntner P, Kusek JW, Chen J, Wu X, Duan X, Chen CS, Klag MJ,
Whelton PK, He J. A population-based, prospective study of blood pressure and risk for
end-stage renal disease in china. J Am Soc Nephrol. 2007; 18:1928-35.
33.
He J, Reynolds K, Chen J, Chen CS, Wu X, Duan X, Reynolds R, Bazzano LA, Whelton
PK, Gu D. Cigarette smoking and erectile dysfunction among Chinese men without
clinical vascular disease. Am J Epidemiol. 2007; 166:803-9.
34.
Bazzano LA, Gu D, Reynolds K, Wu X, Chen CS, Duan X, Chen J, Wildman RP, Klag
MJ, He J. Alcohol consumption and risk for stroke among Chinese men. Ann Neurol.
2007; 62:569-78.
35.
Reynolds K, Gu D, Muntner P, Chen J, Wu X, Yau CL, Duan X, Chen CS, Hamm LL,
He J. Body mass index and risk of ESRD in China. Am J Kidney Dis. 2007; 50:754-64.
36.
Chen J. Townsend RR. Preventing cardiovascular and renal complications in the
management of hypertension and metabolic syndrome. Expert Opinion on
Pharmacotherapy. 2007; 8:2001-9.
37.
Stevens L, Manzi J, Levey A, Chen J, Deysher A, Ojo A, Poggio M, Steffes M, Zhang L,
Van Lente F, Coresh J, the CKD-EPI Group. Impact of creatinine calibration on
performance of GFR estimating equations in a pooled individual patient database. Am J
Kidney Dis. 2007; 50:21-35.
38.
Gu D, Kelly TN, Wu X, Chen J, Duan X, Huang JF, Chen JC, Whelton PK, He J. Blood
pressure and risk of cardiovascular disease in Chinese men and women. Am J Hypertens.
2008; 21:265-72.
39.
Kelly TN, Gu D, Chen J, Huang J, Chen J, Duan X, Wu X, Yau CL, Whelton PK, He J.
Hypertension subtype and risk of cardiovascular disease in Chinese adults. Circulation.
2008; 118:1558-66.
40.
Reynolds K, Gu D, Chen J, Wu X, Yau CL, Chen J, Chen CS, Duan X, Hamm LL, He J.
Alcohol consumption and risk of end-stage renal disease among Chinese men. Kidney
Int. 2008; 73:870–6.
41.
Kelly TN, Gu D, Chen J, Huang JF, Chen JC, Duan X, Wu X, Chen CS, He J. Cigarette
smoking and risk of stroke in the Chinese adult population. Stroke. 2008; 39:1688–93.
42.
Reilly KH, Gu D, Duan X, Wu X, Chen CS, Huang J, Kelly TN, Chen J, Liu X, Yu L,
Bazzano LA, He J. Risk factors for chronic obstructive pulmonary disease mortality in
Chinese adults. Am J Epidemiol. 2008; 167:998-1004.
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43.
Chen J, Gu D, Jaquish CE, Chen C, Hixson JE, Rao DC, Lui D, Hamm,LL, Gu C,
Whelton, PK, and He J. Association between blood pressure responses to cold pressor
test and dietary sodium intervention: Results from GenSalt study. Arch Intern Med.
2008; 168:1740-6.
44.
Chen J, Gu D, Whelton SP, Chen CS, Wu, X, Reynolds K, Hamm L, Whelton PW, He J.
Blood pressure and mortality among Chinese patients with cardiovascular disease. J
Hypertens. 2008; 26:859-65.
45.
Zhang Y, Reilly KH, Tong W, Xu T, Chen J, Bazzano LA, Qiao D, Ju Z, Chen C, He J.
Blood pressure and clinical outcome among patients with acute stroke in Inner Mongolia,
China. J Hypertens. 2008; 26:1446-52.
46.
Yang W, Gu D, Chen J, Jaquish CE, Rao DC, Wu X, Hixson JE, Duan X, Kelly TN,
Hamm LL, Whelton PK, He J. Agreement of blood pressure measurements between
random-zero and standard mercury sphygmomanometers. Am J Med Sci. 2008; 336:373378.
47.
Bazzano LA, Gu D, Reynolds K, Chen J, Wu X, Chen CS, Duan X, Chen J, He J.
Alcohol consumption and risk of coronary heart disease among Chinese men. Int J
Cardiol. 2009; 135:78-85.
48.
He J, Gu D, Chen J, Jaquish CE, Rao DC, Hixson JE, Chen JC, Duan X, Huang JF, Chen
C, Bazzano LA, Whelton PK for the GenSalt Collaborative Research Group. Gender
difference in blood pressure responses to dietary sodium intervention in the GenSalt
study. J Hypertens. 2009; 27:48–54.
49.
Gu D, Kelly TN, Wu X, Chen J, Samet JM, Huang JF, Zhu M, Chen JC, Chen CS, Duan
X, Klag MJ, He J. Mortality attributable to smoking in China. N Engl J Med. 2009;
360:150-9.
50.
Chen J, Gu D, Huang J, Rao DC, Jaquish CE, Hixson JE, Chen CS, Chen J, Lu F, Hu D,
Rice T, Kelly TN, Hamm LL, Whelton PK, He J; GenSalt Collaborative Research Group.
Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in
China: a dietary intervention study. Lancet. 2009; 373:829-35.
51.
Gu D, Chen J, Wu X, Duan X, Jones DW, Huang JF, Chen CS, Chen JC, Kelly TN,
Whelton PK, He J. Prehypertension and risk of cardiovascular disease in Chinese adults.
J Hypertens. 2009; 27:700–701.
52.
Bazzano LA, Gu D, Whelton MR, Wu X, Chen CS, Duan X, Chen J, Chen JC, He
J.Body mass index and risk of stroke among Chinese men and women. Ann Neurol.
2009; 67(1):11-20.
53.
DeLoach SS, Appel LJ, Chen J, Joffe MM, Gadegbeku CA, Mohler ER 3rd, Parsa A,
Perumal K, Rafey MA, Steigerwalt SP, Teal V, Townsend RR, Rosas SE. Aortic pulse
pressure is associated with carotid IMT in chronic kidney disease: report from Chronic
Renal Insufficiency Cohort. Am J Hypertens. 2009; 12:1235-1241.
54.
Townsend RR, Wimmer NJ, Chirinos JA, Parsa A, Weir M, Perumal K, Lash JP, Chen J,
Steigerwalt SP, Flack J, Go AS, Rafey M, Rahman M, Sheridan A, Gadegbeku CA,
Robinson NA, Joffe M. Aortic pulse wave velocity in chronic kidney disease: A CRIC
ancillary study. Am J Med. 2009; Dec 17. [Epub ahead of print].
10
55.
Mei H, Gu D, Rice TK, Hixson JE, Chen J, Jaquish CE, Zhao Q, Chen CS, Chen JC, Gu
CC, Kelly TN, He J. Heritability of blood pressure responses to cold pressor test in a
Chinese population. Am J Hypertens. 2009; 22:1096-100.
56.
Kelly TN, Rice TK, Gu D, Hixson JE, Chen J, Liu D, Jaquish CE, Bazzano LA, Hu D,
Ma J, Gu CC, Huang J, Hamm LL, He J. Novel genetic variants in the alpha-adducin and
guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood
pressure. Am J Hypertens. 2009; 22:985-92.
57.
He J, Gu D, Chen J, Wu X, Kelly TN, Huang JF, Chen JC, Chen C-S, Bazzano LA,
Reynolds K, Whelton PK, Klag MJ. Premature deaths attributable to blood pressure in
China: a prospective cohort study. Lancet. 2009; 374:1765-72.
58.
Montasser ME, Shimmin LC, Gu D, Chen J, Gu C, Kelly TN, Jaquish CE, Rice T, Rao
D, Cao J, Chen J, Liu DP, Whelton P, He J, Hixson JE. Blood pressure response to
potassium supplementation is associated with genetic variation in endothelin 1 and
interactions with E selectin in rural Chinese. J Hypertens. 2009 Dec 5. [Epub ahead of
print]
59.
Zhao Q, Gu D, Chen J, Bazzano LA, Rao DC, Hixson JE, Jaquish CE, Cao J, Chen J, Li
J, Rice T, He J. Correlation between blood pressure responses to dietary sodium and
potassium intervention in a Chinese population. Am J Hypertens. 2009; 22:1281-6.
60.
Zhao Q, Hixson JE, Rao DC, Gu D, Jaquish CE, Rice T, Shimmin LC, Chen J, Cao J,
Kelly TN, Hamm LL, He J. Genetic variants in the apelin system and blood pressure
responses to dietary sodium interventions: a family-based association study. J Hypertens.
2010 Jan 30. [Epub ahead of print]
61.
Chen J. Sodium Sensitivity of Blood Pressure in Chinese Populations. Curr Hypertens
Rep. 2010 Apr;12(2):127-34.
62.
Chen J. Epidemiology of hypertension and chronic kidney disease in China. Curr Opin
Nephrol Hypertens. 2010 May;19(3):278-82.
63.
Zhang Y, Thompson AM, Tong W, Xu T, Chen J, Zhao L, Kelly TN, Chen CS, He J.
Biomarkers of inflammation and endothelial dysfunction and risk of hypertension among
Inner Mongolians in China. J Hypertens. 2010; 28:35-40.
64.
Bazzano LA, Gu D, Whelton MR, Wu X, Chen CS, Duan X, Chen J, Chen JC, He J.
Body mass index and risk of stroke among Chinese men and women. Ann Neurol. 2010
Jan;67(1):11-20. PubMed PMID: 20186847.
65.
Zhao Q, Gu D, Kelly TN, Hixson JE, Rao DC, Jaquish CE, Chen J, Huang J, Chen CS,
Gu CC, Whelton PK, He J. Association of genetic variants in the apelin-APJ system and
ACE2 with blood pressure responses to potassium supplementation: the GenSalt study.
Am J Hypertens. 2010 Jun;23(6):606-13. Epub 2010 Mar 11. PubMed PMID: 20224560;
PubMed Central PMCID: PMC2890255.
66.
Zhao Q, Hixson JE, Rao DC, Gu D, Jaquish CE, Rice T, Shimmin LC, Chen J, Cao J,
Kelly TN, Hamm LL, He J. Genetic variants in the apelin system and blood pressure
responses to dietary sodium interventions: a family-based association study. J Hypertens.
2010 Apr;28(4):756-63. PubMed PMID: 20125035; PubMed Central PMCID:
PMC2905479.
11
67.
Montasser ME, Shimmin LC, Gu D, Chen J, Gu C, Kelly TN, Jaquish CE, Rice T, Rao
DC, Cao J, Chen J, Liu DP, Whelton P, He J, Hixson JE. Blood pressure response to
potassium supplementation is associated with genetic variation in endothelin 1 and
interactions with E selectin in rural Chinese. J Hypertens. 2010 Apr;28(4):748-55.
PubMed PMID: 19996987; PubMed Central PMCID: PMC2919321.
68.
Gu D, Kelly TN, Hixsonc JE, Chen J, Liue D, Chen J, Rao DC, Mu J, Ma J, Jaquishi CE,
Rice TK, Gu C, Hamm L, Whelton PK, He J. Genetic variants in the renin-angiotensinaldosterone system and salt-sensitivity of blood pressure. Hypertens. 2010
Jun;28(6):1210-20. PubMed PMID: 20486282; PubMed Central PMCID: PMC2884148.
69.
Chen S, Wang H, Lu X, Liu DP, Chen J, Jaquish CE, Rao DC, Hixson JE, Kelly TN,
Hou L, Wang L, Huang J, Chen CS, Rice TK, Whelton PK, He J, Gu D. Polymorphisms
in the GNB3 and ADD1 genes and blood pressure in a Chinese population. Hum Genet.
2010 May 16. [Epub ahead of print] PubMed PMID: 20473689.
70.
Gu D, Kelly TN, Hixson JE, Chen J, Liu D, Chen JC, Rao DC, Mu J, Ma J, Jaquish CE,
Rice TK, Gu C, Hamm LL, Whelton PK, He J. Genetic variants in the renin-angiotensinaldosterone system and salt sensitivity of blood pressure. J Hypertens. 2010
Jun;28(6):1210-20. PubMed PMID: 20486282; PubMed Central PMCID:
PMC2884148.
71.
Thompson AM, Zhang Y, Tong W, Xu T, Chen J, Zhao L, Kelly TN, Chen CS, Bazzano
LA, He J. Association of obesity and biomarkers of inflammation and endothelial
dysfunction in adults in Inner Mongolia, China. Int J Cardiol. 2010 May 1. [Epub ahead
of print] PubMed PMID: 20439121.
72.
Townsend RR, Chirinos JA, Parsa A, Weir MA, Sozio SM, Lash JP, Chen J,
Steigerwalt SP, Go AS, Hsu CY, Rafey M, Wright JT Jr, Duckworth MJ, Gadegbeku CA,
Joffe MP; Chronic Renal Insufficiency Cohort Investigators. Central pulse
pressure in chronic kidney disease: a chronic renal insufficiency cohort
ancillary study. Hypertension. 2010 Sep;56(3):518-24. Epub 2010 Jul 26. PubMed
PMID: 20660819.
73.
Wang L, Hou L, Li H, Chen J, Kelly TN, Jaquish CE, Rao DC, Hixson JE, Hu D, Chen
CS, Gu C, Chen S, Lu X, Whelton PK, He J, Lu F, Huang J, Liu DP, Gu D; for the
GenSalt Collaborative Research Group. Genetic variants in the renin-angiotensin system
and blood pressure reactions to the cold pressor test. J Hypertens. 2010 Sep 1. [Epub
ahead of print]
74.
Gutiérrez OM, Isakova T, Hyre Anderson A, Anderson C, Bellovich K, Chen J, Lash J,
Negrea L, Scialla J, Robinson N, Ojo A, Feldman HI and Wolf M. Impact of race and
socioeconomic status on serum phosphate concentrations in the Chronic Renal
Insufficiency Cohort Study. JASN 2010: In Press.
75.
Chen J, Hamm LL, Hudaihed A, Chen CS, Teran FJ, Royse K, Rogers S, Shah K, Tarsia
J, Xu J, MD, Rifai N. Association of biomarkers of endothelial dysfunction and
inflammation with chronic kidney disease (submitted).
12
76.
Chen J, Alper B, Kleinpeter MA, Miller C, Balamuthusamy S, Chen CS, Royse K, Rifai
N, Klag MJ, Hamm LL. Serum levels of adipocytokines and risk of chronic kidney
disease (in preparation).
77.
Townsend RR, Anderson AH, Chen J, Gadebegku C, Feldman HI, Fink J, Go AS, Joffe
M, Nessel L, Ojo A, Rader D, Reilly M, Teal V, Teff K, Wright JT, Xie D. Metabolic
syndrome components and cardiovascular disease prevalence in chronic kidney disease
(in preparation).
78.
Chen J, Mohler E, Xie D, Townsend R, Appel L, Shlipak M, Nessel L, Fargo J, Ojo A,
Schreiber M, Strauss L, Raj D. Hamm LL. Novel risk factors for peripheral artery disease
in patients with chronic kidney disease (in preparation).
BOOK CHAPTERS
1.
Chen J, He J. Hypertension in Asia. In: Mohler ER, Townsend R eds. Advanced therapy
in hypertension and vascular disease. BC Decker Inc: Hamilton. 2006:38-47.
ABSTRACTS AND PRESENTATIONS
1.
Chen J, Rou-Jia Ching. Study on ultrasonographic value in the evaluation of neonatal
intracranial hemorrhage and its complications. Accepted by the 35th Annual Convention
of American Institute of Ultrasound in Medicine. Atlanta, Georgia, 1991.
2.
Chen J, Rou-Jia Ching. Normal value measurement of the brain ventricles by ultrasound
in 0-18-month-old infants. Accepted by the 35th Annual Convention of American
Institute of Ultrasound in Medicine. Atlanta, Georgia, 1991.
3.
Busija DW, Chen J. Reversal by increased CFS [H+] and [K+] of phorbol ester induced
arteriolar constriction in piglets. FASEB Journal. 1991; 5:A374 (abstract).
4.
Chen J, Tytell M, Busija DW. Regional distribution of heat shock proteins in piglet
brains after asphyxia or cerebral ischemia. FASEB Journal .1992; 6:A1063 (abstract).
5.
Busija DW, Khreis LY, Chen J. Prostanoids promote arteriolar dilation and mask
arteriolar constriction to oxytocin in piglets. FASEB Journal. 1992; 6:1170 (abstract).
6.
Chen J, He J, Ogden LG, Batuman V, Whelton PK. Serum antioxidant vitamin level and
renal function in US adults. The National Health and Nutrition Examination Survey III.
Presented at the Scientific Sessions 2000, American Heart Association, Circulation 2000;
102: II-868. Abstract # 4165.
7.
Chen J, Muntner P, Hamm L, Fonseca V, Batuman V, Whelton PK, He J. Diabetes,
Insulin Level, Glycemic Control, and Hypercreatininemia in US General Population.
Presented at the 42nd Annual Conference on Cardiovascular Disease Epidemiology of
American Heart Association. Hawaii, April 2002. Abstract # P252.
13
8.
He J, Muntner P, Chen J, Hamm L, Whelton PK. Increased Cardiovascular Disease Risk
Factors in Patients with Chronic Renal Insufficiency. Presented at the 42nd Annual
Conference on Cardiovascular Disease Epidemiology of American Heart Association.
Hawaii, April 2002. Abstract # P296.
9.
Gu D, He J, Duan X, Xin X, Chen J, Wu X, Reynolds K, Mo J, Whelton PK. Prevalence
of Diabetes and Impaired Fasting Glucose in China: The International Collaborative
Study of Cardiovascular Disease in ASIA (InterASIA). Presented at the 42nd Annual
Conference on Cardiovascular Disease Epidemiology of American Heart Association.
Hawaii, April 2002. Abstract # 155. Circulation. 2002; 105:29.
10.
He J, Gu D, Reynolds K, Wu X, Zhao J, Chen J, Liu D, Mo J, Whelton PK. Prevalence
and Awareness of High Blood Cholesterol in China: The International Collaborative
Study of Cardiovascular Disease in ASIA (InterASIA). Presented at the 42nd Annual
Conference on Cardiovascular Disease Epidemiology of American Heart Association.
Hawaii, April 2002. Abstract # 169. Circulation. 2002; 105:32.
11.
He J, Gu D, Wu X, Duan X, Muntner P, Huang G, Reynolds K, Chen J, Reynolds RF,
Su S, Whelton PK. Prevalence, Awareness, Treatment, and Control of Hypertension in
China: The International Collaborative Study of Cardiovascular Disease in ASIA
(InterASIA). Presented at the 19th Scientific Meeting of the International Society of
Hypertension. Prague, Czech, June 2002. Abstract #O087. J Hypertens. 2002; 20 (suppl.
4): S95.
12.
He J, Gu D, Reynolds K, Muntner P, Chen J, Whelton PK. Serum Creatinine Levels in
the Chinese Population: the International Collaborative Study of Cardiovascular Disease
in Asia (InterASIA). Presented at American Society of Nephrology 35th Annual Meeting
and Scientific Exposition. Philadelphia, PA. November 2002. Abstract # F-P0947.
13.
Reynolds K, Gu D, Chen J, Wu X, Muntner P, Reynolds R, Whelton PK, He J.
Prevalence of the Metabolic Syndrome among Adults in China: The International
Collaborative Study of Cardiovascular Disease in ASIA (InterASIA). Presented at the
43rd Annual Conference on Cardiovascular Disease Epidemiology and Prevention of
American Heart Association. Miami, March, 2003. Abstract # P4. Circulation. 2003;
107:e7010.
14.
Reynolds K, Gu D, Muntner P, Wu X, Chen J, Huang G, Duan X, Whelton PK, He J.
Geographic Variations in the Prevalence, Awareness, Treatment and Control of
Hypertension in China. Presented at the 43rd Annual Conference on Cardiovascular
Disease Epidemiology and Prevention of American Heart Association. Miami, March,
2003. Abstract # P69. Circulation. 2003; 107:e7023.
15.
Reynolds K, Gu D, Chen J, Wu X, Muntner P, Reynolds R, Whelton PK, He J.
Prevalence of the Metabolic Syndrome among Adults in China: The International
Collaborative Study of Cardiovascular Disease in ASIA (InterASIA). Presented at the
20th Scientific Meeting of the International Society of Hypertension. Sao Paulo, February
15-19, 2004. Abstract # P401. J Hypertens. 2004; 22:S108.
14
16.
Chen J, Gu D, Reynolds K, Muntner P, Whelton PK, He J. Serum Creatinine Levels in
the Chinese Population: the International Collaborative Study of Cardiovascular Disease
in Asia (InterASIA). Presented at the 20th Scientific Meeting of the International Society
of Hypertension. Sao Paulo, February 15-19, 2004. Abstract # P114. J Hypertens. 2004;
22:S40-s41.
17.
Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J.
The metabolic syndrome and chronic kidney disease in U.S. adults. Presented at the 20th
Scientific Meeting of the International Society of Hypertension. Sao Paulo, February 1519, 2004. Abstract # P170. J Hypertens. 2004; 22:S50.
18.
Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, He J. Prevalence of the
metabolic syndrome among adults in China: The International Collaborative Study of
Cardiovascular Disease in ASIA (InterASIA). Presented at the International Heart Forum
Beijing 2004. Beijing, PR China, September 2004.
19.
Chen J, Gu D, Wildman RP, Hamm LL, Spruill M, Reynolds K, Whelton PK, He J.
Prevalence of chronic kidney disease in Chinese adult population. Presented at the
American Society of Nephrology. St. Louis, October 2004. Abstract #PUB168.
20.
He J, Gu D, Wu X, Duan X, Chen J. Effect of soybean protein on blood pressure: a
randomized controlled trial. Presented at the American Heart Association Scientific
Sessions 2004. New Orleans, Nov 7-10, 2004. Abstract #3588. Circulation. 2004; 110:
III-778.
21.
Reynolds K*, Gu D, Chen J, Wu X, Muntner P, Reynolds R, Whelton PK, He J.
Prevalence of the Metabolic Syndrome among Adults in China: The International
Collaborative Study of Cardiovascular Disease in ASIA (InterASIA). Presented at the
20th Scientific Meeting of the International Society of Hypertension. Sao Paulo, February
15-19, 2004. Abstract # P401. J Hypertens. 2004; 22:S108.
22.
Chen J, Wildman RP, Hamm L, Muntner P, Reynolds K, Whelton PK, He J. Association
between inflammation and insulin resistance in US non-diabetic adults: results from
NHANES III. Presented at the American Heart Association Scientific Sessions 2004.
New Orleans, Nov 7-10, 2004. Abstract #3613. Circulation. 2004; 110:III-783.
23.
Wildman RP, Muntner P, Chen J, He J. Inflammatory markers and peripheral vascular
disease in NHANES 1999-2000. Presented at the American Heart Association Scientific
Sessions 2004. New Orleans, Nov 7-10, 2004. Abstract #3740. Circulation. 2004;
110:III-810.
24.
He J, Gu D, Duan X, Reynolds K, Wu X, Chen C, Chen J, Wildman RP, Whelton PK.
Major Risk Factors for Mortality in China: A Prospective Study of 169,871 Men and
Women. Presented at the 45th Annual Conference on Cardiovascular Disease
Epidemiology and Prevention. Washington DC. Apr 29 - May 2, 2005. Abstract #27;
Circulation. 111(14):e190, 2005.
15
25.
He J, Gu D, Duan X, Reynolds K, Wu X, Chen C, Chen J, Wildman RP, Whelton PK.
Leading Causes of Death in China: A Prospective Study of 169,871 Men and Women.
Presented at the 45th Annual Conference on Cardiovascular Disease Epidemiology and
Prevention. Washington DC. Apr 29 - May 2, 2005. Abstract# P149. Circulation.
111(14):e223-e224, 2005.
26.
Reynolds K, Gu D, Muntner P, Chen J, Duan X, Chen C, Whelton PK, He J. Blood
Pressure and Risk of End-Stage Renal Disease in Chinese Adults. Presented at the 45th
Annual Conference on Cardiovascular Disease Epidemiology and Prevention.
Washington DC. Apr 29 - May 2, 2005. Abstract# P233. Circulation. 111(14):e240,
2005.
27.
Chen J, Whelton PK, He J. A randomized controlled trial of dietary fiber intake on
serum lipids. Presented at the 12th World Congress on Heart Disease. Vancouver,
Canada, Jul 16-19. Abstract # 35. J Heart Dis; 4(1):9, 2005.
28.
He J, Gu D, Chen J, Reynolds K, Chen C, Wildman R, Whelton P. Major causes of death
in China: A prospective cohort study of 169,871 men and women. Presented at the 12th
World Congress on Heart Disease. Vancouver, Canada, Jul 16-19. Abstract # 88. J Heart
Dis. 2005; 4(1):22.
29.
Chen J, Gu D, Reynolds K, Whelton PK, He J. Serum total and lipoprotein cholesterol
levels and awareness, treatment, and control of hypercholesterolemia in China. Presented
at the 12th World Congress on Heart Disease. Vancouver, Canada, Jul 16-19. Abstract #
200. J Heart Dis. 2005; 4(1):50.
30.
He J, Gu D, We X, Chen J, Whelton PK. Effect of soybean protein on blood pressure: a
randomized controlled trial. Presented at the 12th World Congress on Heart Disease.
Vancouver, Canada, Jul 16-19. Abstract # 230. J Heart Dis. 2005 4(1):58.
31.
Chen J, Gu D, Chen CS, Wu X, Hamm L, Muntner P, Batuman V, Lee C-H, Whelton
PK, He J. Metabolic syndrome and chronic kidney disease in Chinese adults. Presented at
American Society of Nephrology Renal Week. Philadelphia, Pennsylvania, November 8 13, 2005. Abstract # TH-PO942. J Am Soc Nephrol. 2005; 16:325A.
32.
He J, Gu D, Reynolds K, Chen J, Wu X, Duan X, Chen C-S, Whelton PK. Overweight
and risk of stroke in China: A prospective study of 169,871 men and women. Presented at
the 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.
Phoenix, AZ, March 2-5, 2006. Abstract # P14. Circulation. 2006; 113: e14.
33.
Gu D, He J, Wu X, Reynolds K, Huang G, Chen J, Duan X, Chen C-S, Whelton PK.
Body weight and mortality among men and women in China. Presented at the 46th
Annual Conference on Cardiovascular Disease Epidemiology and Prevention. Phoenix,
AZ, March 2-5, 2006. Abstract # P197. Circulation. 2006; 113: e50-e51.
34.
Chen J, Gu. D, Whelton SP, Wu X, Chen CS, Duan X, Reynolds K, Hamm LL, Whelton
PK, He J. Blood Pressure and Mortality in Men and Women with Cardiovascular
Disease. Presented at the 60th Annual Fall Conference and Scientific Sessions of the
16
Council for High Blood Pressure Research in Association with the Council on the Kidney
in Cardiovascular Disease. October 4 – October 7, 2006, San Antonio, Texas.
35.
Chen J, Gu D, Cashell JE, Chen CS, Rao DC, Reynolds K, Hixson JE, Hamm LL,
Whelton PK, He J. Blood Pressure Response to Cold Pressor Predicts Salt-Sensitivity in
the GenSalt Study. Presented at American Society of Nephrology Renal Week. San
Diego, California, November 16-19, 2006. Abstract # F-PO427.
36.
Chen J, Gu D, Hmm LL, Chen CS, MS, Rao DC, Cashell JE, Hixson JE, Whelton PK,
He J. Kidney Function and Salt-Sensitivity of Blood Pressure in the GenSalt Study.
Presented at American Society of Nephrology Renal Week. San Diego, California,
November 16-19, 2006. Abstract # F-PO208.
37.
Chen J, Gu D, Jaquish CE, Chen C, Rao DC, Reynolds K, Hixson JE, Hamm LL,
Whelton PK, He J. Blood pressure response to cold pressor predicts salt-sensitivity in the
GenSalt study. Presented at the American Heart Association Scientific Sessions 2006.
Chicago, IL, November 12-15, 2006. Abstract # 3942. Circulation. 2006; 114: II847-848.
38.
He J, Gu D, Jaquish CE, Rao DC, Hixson JE, Chen J, Chen CS, Gu CC, Liu DP,
Whelton PK. Gender difference in blood pressure responses to low and high dietary
sodium intervention in the GenSalt study. Presented at the 47th Annual Conference on
Cardiovascular Disease Epidemiology and Prevention. Orlando, FL. February 28-March
3, 2007. Abstract #P152. Circulation. 2007; 115(8):e254.
39.
He J, Gu D, Chen J, Wu X, Duan X, Chen CS, Reynolds K, Bazzano LA, Whelton PK.
Mortality and hypertension in China. A prospective study of 169,871 men and women.
Presented at the 47th Annual Conference on Cardiovascular Disease Epidemiology and
Prevention. Orlando, FL. February 28-March 3, 2007. Abstract #P153. Circulation. 2007;
115(8):e254.
40.
He J, Gu D, Wu X, Chen CS, Duan X, Bazzano LA, Chen J, Reynolds K, Klag MJ,
Whelton PK. Mortality and smoking in China. A prospective study of 169,871 men and
women. Presented at the 47th Annual Conference on Cardiovascular Disease
Epidemiology and Prevention. Orlando, FL. February 28-March 3, 2007. Abstract #P276.
Circulation. 2007; 115(8):e280.
41.
Stevens L, Manzi J, Levey A, Chen J, Deysher A, Ojo A, Poggio M, Steffes M, Zhang L,
Van Lente F, Coresh J, the CKD-EPI Group. Impact of Creatinine Calibration on
Performance of GFR Estimating Equations in a Pooled Individual Patient Database.
Presented at American Society of Nephrology Renal Week. San Diego, California,
November 16-19, 2006. Abstract # TH-PO176.
42.
Townsend R, Chen J, Chertow GM, Wright JT, Jr, Lo J, For the CRIC Study
Investigators. Influence of race, gender and age on metabolic syndrome prevalence in
CKD. Presented at American Society of Nephrology Renal Week. San Diego, California,
November 16-19, 2006. Abstract # SA-PO301.
17
43.
Chen J, Gu D, Rao DC, Jaquish CE, Hixson JE, Chen C,, Lui D, Hamm,LL, Gu C,
Whelton, PK, and He J. Metabolic Syndrome and Salt-Sensitivity of Blood Pressure
among Chinese Adults. Presented at American Society of Nephrology Renal Week. San
Francisco, California, October 31 -November 5, 2007. Abstract # SA-PO1097. J Am Soc
Nephrol. 2007; 18:586A.
44.
Kelly T, Gu D, Chen J, Huang J, Chen JC, Duan X, Wu X, Yau CL, Whelton PK, He J.
Hypertension subtype and risk of cardiovascular disease in Chinese adults. Presented at
American Heart Association Scientific Sessions 2007, Orlando, FL. Nov 4-7, 2007.
Abstract# 3784. Circulation. 2007; 116:II-860.
45.
Chen J, Gu D, Rao DC, Jaquish CE, Hixson JE, Liu D, Chen C-S, Hamm L, Whelton
PK, He J. Metabolic syndrome and salt-sensitivity of blood pressure among Chinese
adults. Presented at 48th Cardiovascular Disease Epidemiology and Prevention Annual
Conference, American Heart Association, March 13 – 15, 2008, Colorado Springs,
Colorado. Abstract #P255. Circulation. 2008; 117 (11):e264.
46.
Gu D, Chen J, Wu X, Duan X, Jones DW, Huang J, Chen J-C, Chen C-S, Kelly TN,
Whelton PK, He J. Prehypertension and risk of cardiovascular disease in Chinese adults.
Presented at 48th Cardiovascular Disease Epidemiology and Prevention Annual
Conference, American Heart Association, March 13 – 15, 2008, Colorado Springs,
Colorado. Abstract #P256. Circulation. 2008; 117 (11):e264.
47.
Gu D, Chen J, Wu X, Duan X, He J. Prehypertension and risk of cardiovascular disease
in Chinese adults. Presented at the 2008 International Society of Hypertension Meeting,
June 14–19, 2008, Berlin, Germany. Abstract# PS02/MON/10. J Hypertens. 2008;
26:S53.
48.
Kelly T, Gu D, Chen J, Wu X, Duan X, He J. Blood pressure and risk of cardiovascular
disease in Chinese men and women. Presented at the 2008 International Society of
Hypertension Meeting, June 14–19, 2008, Berlin, Germany. Abstract PS05/MON/08. J
Hypertens. 2008; 26:S88.
49.
Chen J, Gu D, Chen C, Liu D, Hamm L, Whelton P, He J. Association between blood
pressure responses to cold pressor test and dietary sodium intervention in the Chinese
population. Presented at the 2008 International Society of Hypertension Meeting, June
14–19, 2008, Berlin, Germany. Abstract PS05/MON/09. J Hypertens. 2008; 26:S88.
50.
Chen J, Gu D, Chen C, Hamm L, Liu D, Whelton P, He J. Metabolic syndrome and saltsensitiivty of blood pressure among Chinese adults. Presented at the 2008 International
Society of Hypertension Meeting, June 14–19, 2008, Berlin, Germany. Abstract
PS05/MON/10. J Hypertens. 2008; 26:S88.
51.
Kelly T, Gu D, Chen J, Huang J, Chen JC, Duan X, Wu X, Whelton P, He J.
Hypertension subtype and risk of cardiovascular disease in Chinese adults. Presented at
the 2008 International Society of Hypertension Meeting, June 14–19, 2008, Berlin,
Germany. Abstract PS05/MON/53. J Hypertens. 2008; 26:S98.
18
52.
Zhang Y, Reilly K, Tong W, Xu T, Chen J, Bazzano L, Qiao D, Ju Z, Chen C, He J.
Blood pressure and clinical outcome among patients with acute stroke in Inner Mongolia,
China. Presented at the 2008 International Society of Hypertension Meeting, June 14–19,
2008, Berlin, Germany. Abstract PS28/WEN/07. J Hypertens. 2008; 26:S395.
53.
He J, Wofford MR, Reynolds K, Chen J, Royse KE, Chen C-S, Myers L, Elmer PJ,
Jones DW, Whelton PK. Effect of dietary protein supplementation on blood pressure: A
randomized controlled trial. Presented at American Heart Association Scientifc Sessions
2008, New Orleans, LA, November 8-12. Abstract # 5138.
54.
Chen J, L. Hamm L, Hudaihed A, Townsend R, Mohler E, Chen C, Royse K, Rogers S,
Xu J, Rifai N, He J. Plasma levels of biomarkers of endothelial dysfunction and risk of
chronic kidney disease(CKD). Presented at American Society of Nephrology Renal
Week. Philadelphia, Pennsylvania, November 4 -November 9, 2008. Abstract #FPO1938.
55.
Chen J, Alper AB, Miller C, Kleinpeter MA, Balamuthusamy S, Royse K, Chen C,
Powers L, Tarsia J, Rifai N, Hamm LL. Plasma Levels of Leptin, Resistin, and
Adiponectin and Risk of Chronic Kidney Disease. Presented at American Society of
Nephrology Renal Week. Philadelphia, Pennsylvania, November 4 -November 9, 2008.
Abstract #F-PO1945.
56.
Zhang YL, Stevens LA, Schmid CH, Chen J, Horio M, Imai E, Matsuo S, Nelson RG,
Wang HY, Zuo L, Levey AS. Development and Validation of GFR Estimating Equations
for Use in Multiple Races and Ethnicity. Presented at American Society of Nephrology
Renal Week. Philadelphia, Pennsylvania, November 4 -November 9, 2008. Abstract
#SA-PO2891.
57.
Zhang Y, Chen J, Xu T, Kelly TN, Zhao L, Chen CS, He J. Biomarkers of endothelial
dysfunction and inflammation and risk of metabolic syndrome among Inner Mongolians
in China. Presented at the 49th Cardiovascular Disease Epidemiology and Prevention
Annual Conference, American Heart Association, March 10 – 14, 2009, Palm Harbor,
Florida. Abstract #P83. Circulation. 2009; 119(10):e301.
58.
Bazzano LA, Gu D, Chen J, Huang J, Rao DC, Jaquish CE, Hixson JE, Chen CS, Chen
JC, Duan X, Rice T, Kelly TN, Hamm LL, Whelton PK, He J. Effect of dietary sodium
and potassium intervention on blood lipids. Presented at the 49th Cardiovascular Disease
Epidemiology and Prevention Annual Conference, American Heart Association, March
10 – 14, 2009, Palm Harbor, Florida. Abstract #P179. Circulation. 2009; 119(10):e321.
59.
Zhang Y, Kelly TN, Xu T, Chen J, Zhao L, Chen CS, He J. Biomarkers of endothelial
dysfunction and inflammation and risk of hypertension among Inner Mongolians in
China. Presented at the 49th Cardiovascular Disease Epidemiology and Prevention
Annual Conference, American Heart Association, March 10 – 14, 2009, Palm Harbor,
Florida. Abstract #P192. Circulation. 2009; 119(10):e324.
60.
He J, Gu D, Kelly TN, Hixson JE, Rao DC, Jaquish CE, Chen J, Gu CC, Huang JF,
Shimmin LC, Liu D, Whelton PK. Genetic variants in the aldosterone system and blood
19
pressure responses to potassium intake. Presented at the 49th Cardiovascular Disease
Epidemiology and Prevention Annual Conference, American Heart Association, March
10 – 14, 2009, Palm Harbor, Florida. Abstract #P193. Circulation. 2009; 119(10):e324.
61.
Mei H, Gu D, Rice T, Hixson JE, Chen J, Jaquish CE, Zhao Q, Chen CS, Chen JC, Gu
CC, Kelly TN, He J. Heritability of blood pressure response to cold pressor test in a
Chinese population. Presented at the 49th Cardiovascular Disease Epidemiology and
Prevention Annual Conference, American Heart Association, March 10 – 14, 2009, Palm
Harbor, Florida. Abstract #P213. Circulation. 2009; 119(10):e329.
62.
Zhao Q, Gu D, Hixson JE, Rao DC, Jaquish CE, Chen J, Huang JF, Kelly TN, Gu CC,
Whelton PK, He J. Association between genetic variants of the ACE2 and apelin-APJ
system and blood pressure responses to a dietary potassium supplement: The GenSalt
Study. Presented at the 49th Cardiovascular Disease Epidemiology and Prevention
Annual Conference, American Heart Association, March 10 – 14, 2009, Palm Harbor,
Florida. Abstract #P215. Circulation. 2009; 119(10):e329.
63.
Kelly TN, Gu D, Hixson JE, Chen J, Liu D, Chen JC, Rao DC, Mu J, Ma J, Jaquish CE,
Whelton PK, He J. Genetic variants in the renin-angiotensin system and salt sensitivity
of blood pressure. Presented at the 49th Cardiovascular Disease Epidemiology and
Prevention Annual Conference, American Heart Association, March 10 – 14, 2009, Palm
Harbor, Florida. Abstract #P217. Circulation. 2009; 119(10):e330.
64.
Kelly TN, Chen J, Chen JC, Hixson JE, Rao DC, Liu D, Jaquish CE, Rice TK, Gu CC,
Whelton PK, Gu D, He J. The association between novel genetic variants in the ADD1
and GNB3 genes and salt sensitivity of blood pressure. Presented at the 49th
Cardiovascular Disease Epidemiology and Prevention Annual Conference, American
Heart Association, March 10 – 14, 2009, Palm Harbor, Florida. Abstract #P218.
Circulation. 2009; 119(10):e330.
65.
Zhao Q, Gu D, Hixson J, Rao DC, Jaquish CE, Chen J, Huang J, Kelly TN, Gu CC,
Whelton PK, He J. Association between Genetic Variants of the ACE2 and Apelin-APJ
System and Blood Pressure Responses to a Dietary Potassium Supplement: the GenSalt
Study. Presented at the 49th Cardiovascular Disease Epidemiology and Prevention
Annual Conference, American Heart Association, March 10 – 14, 2009, Palm Harbor,
Florida. Abstract # P215
66.
Thompson AM, Zhang Y, Tong W, Xu T, Chen J, Zhao L, Kelly TN, Chen CS, Bazzano
LA, He J. Association of Inflammation, Endothelial Dysfunction and Glycemic Status in
Adults in Inner Mongolia, China. Abstract No. 816. Poster presentation at the American
Heart Association Cardiovascular Disease Epidemiology and Prevention and Nutrition,
Physical Activity and Metabolism Conference, March 3, 2010, San Francisco, California.
Abstract # P132.
67.
Thompson AM, Zhang Y, Tong W, Xu T, Chen J, Zhao L, Kelly TN, Chen CS, Bazzano
LA, He J. Association of Obesity and Biomarkers of Inflammation and Endothelial
Dysfunction in Adults in Inner Mongolia, China. Abstract No. 827. Poster presentation
20
at the American Heart Association Cardiovascular Disease Epidemiology and Prevention
and Nutrition, Physical Activity and Metabolism Conference, March 3, 2010, San
Francisco, California. Abstract # P158.
68.
Gutiérrez OM, Isakova T, Hyre Anderson A, Anderson C, Bellovich K, Chen J, Lash J,
Negrea L, Scialla J, Robinson N, Ojo A, Feldman HI and Wolf M. On behalf of the CRIC
Study Group. Race and Serum Phosphate Concentrations in the Chronic Renal
Insufficiency Cohort Study (CRIC) Presented at American Society of Nephrology Renal
Week. October 27 - November 1, 2009, San Diego, California. Abstract # F-PO1863.
69.
Zhao Q, Gu D, Chen J, Bazzano LA, Rao DC, Hixson J, Jaquish CE, Cao J, Chen JC, Li
J, Rice T, He J. Correlation between Blood Pressure Responses to Dietary Sodium and
Potassium Intervention in a Chinese Population. Presented at the American Heart
Association, Scientific Session, Nov 15-17, 2009, Orlando, FL. Abstract # P1104
INVITED PRESENTATIONS
1.
Chen J. Invited speaker. The prevalence of chronic kidney disease in China. KDIGO
(Kidney Disease: Improving Global Outcomes) international controversies meeting,
October 12-14, 2006, Amsterdam, Netherland.
ON-GOING RESEARCH
Role:
Junior Faculty Principal Investigator for Subproject 5 (25% effort)
Project:
Tulane COBRE in Hypertension and Renal Biology
Period of support:
09/2007–08/2012
Funding source:
NCRR/NIH (P20RR017659)
Funding level:
$12 millions
Principal Investigator: Luis Gabriel Navar, PhD
Objectives
The objectives of this proposal are to provide an enriched mentoring
environment to junior faculty investigators so that they can achieve
independent status and national competitiveness and to augment and
strengthen biomedical research capacity at Tulane University Health
Sciences Center and the State of Louisiana in hypertension and associated
renal and cardiovascular disease.
Subproject 5:
Endothelial Dysfunction, Inflammation, Adipocytokines and Chronic
Kidney Disease
The objective of this subproject is to study the association of biomarkers
of endothelial dysfunction, inflammation, and adipocytokines with risk of
chronic kidney disease.
Role:
Project:
Period of support:
Funding source:
Site Principal Investigator (5% effort)
Carotid Intima-Media Thickness in Chronic Kidney Disease: a CRIC
Ancillary Study
09/15/2008-6/30/2013
NIDDK/NIH (R01 DK080033)
21
Funding level:
$954,944
Principal Investigator: Sylvia Rosas, MD
Objectives:
The aims of this cross-sectional, multi-center study are to determine the
prevalence and risk factors for increased carotid IMT and progression of
carotid IMT in patients participating in the Chronic Renal Insufficiency
Cohort (CRIC) study. Additionally, we will determine if IMT is a
predictor for cardiovascular events and mortality in CKD, and evaluate if
IMT adds to the prediction ability of standard prediction scores such as
Framingham.
Role:
Co-Investigator (20% effort)
Project:
Clinical Center for Prospective Cohort Study of CRI (CRIC II)
Period of support:
07/01/2008 – 06/30/2013
Funding source:
NIDDK/NIH (U01-DK60963)
Funding level:
$3,408,188
Principal Investigator: Jiang He, MD, PhD
Objectives:
The major goals of this project are to examine risk factors for the
progression of renal disease and development of cardiovascular disease in
patients with chronic renal insufficiency.
Role:
Co-Investigator (20% effort)
Project:
Sodium Sensitivity and Incidence of Hypertension
Period of support:
08/15/2007 – 07/31/2011
Funding source:
NHLBI/NIH (R01 HL087263)
Funding level:
$2,260,500
Principal Investigator: Jiang He, MD, PhD
Objectives:
The major objectives of this study are to examine the relationship between
blood pressure responses to dietary sodium intervention and the risk of
hypertension and to examine the association between variants in biological
candidate genes and the risk of hypertension.
Role:
Project:
Co-Investigator (20% effort)
Family-based Genome-wide Association Study for Salt-Sensitivity of
Blood Pressure
Period of support:
09/15/2008 – 07/31/2012
Funding source:
NHLBI (R01 HL090682)
Funding level:
$2,870,667
Principal Investigator: Jiang He, MD, PhD
Objectives:
The overall objectives of the proposed study are to identify genes for
blood pressure responses to dietary sodium intervention using two-stage
genome-wide association study approach.
Role:
Project:
Period of support:
Funding source:
Co-Investigator (10% effort)
Sodium and CVD in Patients with Kidney Disease
06/01/2008 – 05/31/2011
NIDDK/NIH (R01 DK074615)
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Funding level:
$726,666
Principal Investigator: Jiang He, MD, PhD
Objectives:
The major objectives of this study are to examine the relationship between
dietary intake of sodium, potassium, calcium, and magnesium and the risk
of cardiovascular disease among patients with chronic kidney disease.
PENDING RESEARCH
Role:
Project:
Period of support:
Funding source:
Funding level:
Objectives:
Principal Investigator (25% effort)
Biomarkers of Endothelial Dysfunction and Cardiovascular Risk
among CKD Patients
07/01/2010–06/30/2013
KNOD/NIH (1 R01 DK083979-01A1)
$ 1,562,245
The overall objective of the proposed study is to examine the association
between the biomarkers of endothelial dysfunction and the risk of CVD
among patients with chronic renal insufficiency.
(It has been recommended for funding and is pending NIDDK council
meeting in May 2010).
Role:
Site Principal Investigator (10% effort)
Project:
Carbamylated Low-density Lipoprotein and Cardiovascular Events
Period of support:
08/15/2010-6/30/2012
Funding source:
NHLBI/NIH (1R01HL104071-01)
Funding level:
$742,139
Principal Investigator: Sudhir V Shah, MD
Objectives:
The overall objective is to investigate carbamylated low-density
lipoprotein and cardiovascular events among patients with chronic kidney
disease.
Role:
Project:
Period of support:
Funding source:
Funding level:
Objectives:
Role:
Project:
Period of support:
Funding source:
Funding level:
Principal Investigator:
Principal Investigator ( 25% effort)
Vascular Calcification Biomarkers and Risk of CVD among Patients
with CKD
12/01/2010- 11/30/2013
NHLBI/NIH (1R01HL106094-01)
$ 1,187,187
The overall objective of the proposed study is to examine the prospective
relationship between vascular calcification biomarkers and risk of CVD
among patients with CKD.
Co-Investigator (20% effort)
Trial of Antihypertensive Medications and Risk of Dysglycemia
07/01/2010–06/30/2014
NHLBI/NIH/NIH
$3,042,317 (total costs: $7,598,882)
Jiang He, MD, PhD
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Objectives:
The proposed multi-center, randomized, double-blind trial will test whether
avoidance of hypokalemia or blockade of the renin-angiotensin-aldosterone
system will prevent thiazide-induced dysglycemia and investigate the potential
mechanisms of thiazide-induced dysglycemia.
COMPLETED RESEARCH
Role:
Scholar (75% effort)
Project:
BIRCWH Interdisciplinary Research in Women’s Health Scholarship
Period of support:
07/01/2003-06/30/2005
Funding source:
NIH
Principal Investigator: Paul K. Whelton, MD
This award provides support for junior faculty with an interest in women’s
health research.
Role:
Co-Investigator (20% effort)
Project:
Clinical Center for Prospective Cohort Study of CRI
Period of support:
08/01/2001 – 06/30/2008
Funding source:
NIDDK/NIH (U01-DK60963)
Funding level:
$4,402,718
Principal Investigator: Jiang He, MD, PhD
Objectives:
The major goals of this project are to examine risk factors for the
progression of renal disease and development of cardiovascular disease in
patients with chronic renal insufficiency.
Role:
Co-Investigator (20% effort)
Project:
Clinical Trial of Dietary Protein on Blood Pressure
Period of support:
07/01/2002 – 06/30/2008
Funding source:
NHLBI/NIH (R01 HL68057)
Funding level:
$2,881,270
Principal Investigator: Jiang He, MD, PhD
Objectives:
The major goals of this project are to examine the effect of soy and milk
protein supplementation on blood pressure, lipids, and other
cardiovascular disease risk factors in a randomized crossover clinical trial.
Role:
Co-Investigator (20% effort)
Project:
Genetic Epidemiology of Blood Pressure Intervention
Period of support:
09/30/2002 – 05/31//2009
Funding source:
NHLBI/NIH (U01 HL072507)
Funding level:
$7,618,499
Principal Investigator: Jiang He, MD, PhD
Objectives:
The overall objective of this study is to identify susceptibility genes that
influence individual blood pressure responses to environmental risk
factors for hypertension in human populations.
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