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Association for Quality Assessment in TDM and Clinical Toxicology DRUGS OF ABUSE ROUND 2016.3A Section of the Dutch Foundation for Quality Assessment in Medical Laboratories Deadline September 29 SKML nr.: You can download this form: www.kkgt.nl: English version, scroll down till Drugs of Abuse and mail to [email protected] Fictitious case, so please do a drug test also when this would not be normal policy in your lab: Sample for a routine drug screening. N.B. Methanol is used as solvent. URINE SCREENING ROUND 2016.3A OPIATES COCAINE (benzoylecgonine) AMPHETAMINES & ANALOGUES*** Amphetamine*** Methamphetamine*** MDA*** MDMA*** MDEA*** CANNABINOIDS (nor-∆9-THCCOOH) METHADONE EDDP BENZODIAZEPINES specificy calibrator BARBITURATES specificy calibrator ETHANOL (g/l) ETHYLGLUCURONIDE Cut-off μg/l 300 300 1000 1000 1000 1000 1000 1000 50 300 100 200 conc. μg/l method code E/N* result** N/ P/ NT 200 0,1 500 OTHER DRUGS * E: enzymatic hydrolysis or N: nonenzymatic hydrolysis * *N: negative, P: positive or NT: not tested ***For amphetamine like components the tests is positive when the sum of the different components >1000 µg/l Creatinine: mmol/l. This urine sample is: normal / dilute(d) / abnormal Methodecode: 1. FPIA 6. RAPID ON-SITE TESTING a. Axsym f. Architect a. Syva Rapid j. Sure Screen b. TDx/FLx 3. CEDIA b. Micron k. Quick Screen c. FPIA, COBAS 4. KIMS(=online) c. Triage l. Bio-Rad 2. EIA 5. ELISA d. Abusign m. Dima a. EMIT II a. COZART e. Accusign n. Fastect II b. EMIT II plus b…………. f. Ontrack o. Acon One Step c. Beckman Coulter g. Abuscreen p. Testcard9 d. DRI h. Druglab q. ……… e. DST i. SSD Rapid Drug Test 7. other immuno-chemical (semi) quantitative technics COMMENT Postbus 43100, 2504 AC Den Haag, Tel. (0031-70) 3 217 161, www.kkgt.nl, E-mail: [email protected] Association for Quality Assessment in TDM and Clinical Toxicology Section of the Dutch Foundation for Quality Assessment in Medical Laboratories DRUGS OF ABUSE ROUND 2016.3A Cut-off μg/l URINE CONFIRMATION ROUND 2016.3A Opiates: Deadline September 29 6 MAM 15 MORPHINE 300 CODEINE 300 Cocaine : BENZOYLECGONINE 150 Amphetamines: AMPHETAMINE 500 METHYLAMPHETAMINE 500 MDA 500 MDMA 500 MDEA 500 Cannabis : THC (1-nor-9-COOH-9-THC) 15 Methadone: METHADONE 300 EDDP 100 Benzodiazepines ……………………… 100 Barbiturates: ……………………… Ethanol (g/l): ETHANOL 0,1 ETHYLGLUCURONIDE 500 Other drugs: * ** conc. μg/l method code SKML nr.: result** N/ P/ NT E/N* ……………………… E: enzymatic hydrolysis or N: nonenzymatic hydrolysis N: negative, P: positive or NT: not tested Method code: 8. TLC 9. HPLC 10. GC a. Toxilab a. STIP/DAD a. MS* b. Conventional b. UV/FLU/EC b. FID/NPD/EC c. HPTLC c. MS* c. …………… d…………… d. …………….. *: details van MS-detectie: ………………………………………………………………………………………….. Extraction : (liquid, pH, derivatized) liquid /solid phase: ……………………………………………………………… derivatized pH :……. : no / yes with: …………………………………………………………………… COMMENT: Postbus 43100, 2504 AC Den Haag, Tel. (0031-70) 3 217 161, www.kkgt.nl, E-mail: [email protected]