Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Powerpoint - Blood Journal
Document related concepts
no text concepts found
Transcript
Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates by Enrico Lugli, Carolyn K. Goldman, Liyanage P. Perera, Jeremy Smedley, Rhonda Pung, Jason L. Yovandich, Stephen P. Creekmore, Thomas A. Waldmann, and Mario Roederer Blood Volume 116(17):3238-3248 October 28, 2010 ©2010 by American Society of Hematology IL-15 administration alters the peripheral blood count of multiple lymphocyte subsets. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology IL-15 administration expands multiple subsets of NK and memory T cells. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology IL-15 treatment preferentially targets memory T cells and induces their proliferation and the expression of multiple activation markers. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology Activation and proliferation of memory T cells after treatment with IL-15 occurs in multiple tissues. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology Accumulation of CD8+ T cells in peripheral tissues is not a consequence of local IL-15–induced expansion. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology IL-15 treatment does not lead to long-lasting (day 48) accumulation of NK and memory T cells, but chronically alters the balance of CD4+ and CD8+ T cells. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology Proposed model for IL-15 function in vivo. Enrico Lugli et al. Blood 2010;116:3238-3248 ©2010 by American Society of Hematology
Related documents