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ROBUST STUDY SUMMARY - Inherent Toxicity
Item
Yes
No
Reference: Kopperman, H.L., R.M. Carlson, and R. Caple. 1974. Aqueous Chlorination and Ozonation Studies. I.
Structure-Toxicity Correlations of Phenolic Compounds to Daphnia magna. Chem.-Biol. Interact. 9(4):245-251.
Test Substance: CAS # and name (specify, but do not assess this item): 90-05-1 (2-Methoxyphenol)
* Substance purity reported? (Y/N and specify)
X
Persistence/stability of test substance in aquatic solution reported? (Y/N)
X
Method
References (Y/N)
*OECD, EU, national, or other standard method? (Y/N)
If not a standard method, justification of the method/protocol provided? (Y/N)
*GLP (Good Laboratory Practice) (Y/N)
Test organisms (specify common and/or Latin names) Daphnia magna
Latin or both Latin and common names reported? (Y/N)
Life cycle age / stage of test organism (Y/N)
Sex (Y/N)
Length and/or weight of test organisms (Y/N)
Number of test organisms per replicate (Y/N)
Food type / feeding periods (acclimation/during test) (Y/N)
Test design / conditions
Test type – acute or chronic (specify, but do not assess this item):
Experiment type (laboratory or field) specified? (Y/N)
System type (static, semi-static, flow-through) (Y/N)
Negative or positive controls? (Y/N and specify)
Number of replicates (including controls) and concentrations (Y/N)
Exposure pathways (food, water, both) (Y/N) Water
Exposure duration (Y/N and specify) 96 hours
*Measured concentrations reported? (Y/N)
Exposure media conditions (temperature, pH, electrical conductivity, hardness, TOC,
DOC, DO, major cations and anions; other) (Y/N)
Was pH within 6-9 range? (do not assess this item)
Was temperature within 5-28 °C range? (do not assess this item)
Photoperiod and light intensity (Y/N)
Stock and test solution preparation (Y/N)
Information on emulsifiers used for poorly soluble / unstable substances (Y/N)
Analytical monitoring intervals (Y/N)
Statistical methods used (Y/N)
X
X
X
Not applicable
X
X
Not applicable
X
X
X
X
X
X
X
X
X
X
X
No data
X
X
X
Not applicable
X
X
Results
Toxicity endpoints / values / units (specify, but do not assess this item): 48-h LC50 = 26 mg/L
Other endpoints reported (e.g. BCF/BAF, LOEC/NOEC, etc.) (specify, but do not assess this item):
*Was toxicity value below the chemical’s water solubility? (Y/N) WS = 18700 mg/L
X
Other adverse effects (carcinogenicity, mutagenicity, etc. Do not assess this item)
Score: major items – 1/4 ;
overall score: 12/23 = 52%
EC Reliability code: 3
Reliability category (high, satisfactory, low): Low
Comments: Not a standard method; no references and method justification. Purity is not reported. Nominal concentrations
were used. Water chemistry parameters were not reported. Poor documentation.
A.Okonski. June 8, 2004