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What is going on between defibrotide and endothelial
cells? Snapshots reveal the hot spots of their romance
by Marta Palomo, Enrique Mir, Montse Rovira, Ginés Escolar, Enric Carreras, and
Maribel Diaz-Ricart
Blood
Volume 127(13):1719-1727
March 31, 2016
©2016 by American Society of Hematology
Uptake of defibrotide by endothelial cells.
Marta Palomo et al. Blood 2016;127:1719-1727
©2016 by American Society of Hematology
DF internalization by SK cells.
Marta Palomo et al. Blood 2016;127:1719-1727
©2016 by American Society of Hematology
Specificity of DF labeling and DF interaction with ECs. (A) Confocal microscopy images show no
green staining when SK cells (red staining with wheat germ agglutinin for membranes) were
incubated only with Alexa 488 compared with (B) the incubation of SK cel...
Marta Palomo et al. Blood 2016;127:1719-1727
©2016 by American Society of Hematology
DF is internalized by ECs through macropinocytic mechanisms.
Marta Palomo et al. Blood 2016;127:1719-1727
©2016 by American Society of Hematology
Inflammation of ECs is prevented by DF interaction with the cell membrane.
Marta Palomo et al. Blood 2016;127:1719-1727
©2016 by American Society of Hematology
The antioxidant effect of DF on ECs is caused by its interaction with the cell membrane.
Marta Palomo et al. Blood 2016;127:1719-1727
©2016 by American Society of Hematology
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