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Download Supplementary Table 2. lite-1 mutations Allele Genomic sequence
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Supplementary Table 2. lite-1 mutations Allele Genomic sequence Genomic sequence in N2 (wild type) in mutant TTT AT AGT ce302 TTG GT AGT CTG AAT TC ce303 CTG GAT TC CTC TGA GA ce304 CTC TGG GA GCG AT ATT ce314 GCG GT ATT CTT TAG GA ce318 CTT CAG GA TCT TAA AT ce319 TCT CAA AT TCC AA GGA ce320 TCC AG GGA TCC AA TGT ce327 TCC AG TGT TTA TCA GC ce329 TTA CCA GC CTT TTT GGC ce338 CTT TTG GC TAT TAA AG ce340 TAT CAA AG TGC TCG CT ce341 TGC CCG CT AAT TAA TC ce342 AAT CAA TC TCC TGT GC ce343 TCC CGT GC TTG AA GTG ce345 TTG AG GTG Effect on lite-1 gene or protein Splice donor site after end of 9th exon D214N W419 Stop Splice donor site after end of 6th exon Q106 Stop Q376 Stop Splice acceptor site before start of 9th exon Splice acceptor site before start of 6th exon P342S Insertion of T in 178th codon causing frameshift Q276 Stop P259S Q62 Stop R222C S126N (mutation is in last base of exon; cDNA change is AGC to AAC) ce312, ce316, and ce331, isolated from separate mutageneses, have the same mutation as ce302.
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