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Chemokine stromal cell-derived factor-1α modulates VLA-4
integrin-mediated multiple myeloma cell adhesion to CS1/fibronectin and VCAM-1
by Francisco Sanz-Rodrı́guez, Andrés Hidalgo, and Joaquin Teixidó
Blood
Volume 97(2):346-351
January 15, 2001
©2001 by American Society of Hematology
Expression and functionality of CXCR4 on BM myeloma cells.(A) Myeloma CD38hiCD45RA− BM
cells and myeloma-derived cell lines were incubated with the anti-CXCR4 44.717.111 or control
[C] P3X63 mAb and analyzed by flow cytometry.
Francisco Sanz-Rodrı́guez et al. Blood 2001;97:346-351
©2001 by American Society of Hematology
Effect of SDF-1α on VLA-4–dependent myeloma cell adhesion.BCECF-AM–labeled cells were
preincubated in adhesion medium in the absence or in the presence of SDF-1α (100 ng/mL) for 5
or 30 minutes (A) or for the times indicated (NCI-H929 cells) (B) and were al...
Francisco Sanz-Rodrı́guez et al. Blood 2001;97:346-351
©2001 by American Society of Hematology
Effect of pertussis toxin and cytochalasin D on SDF-1α–up-regulated VLA-4–dependent myeloma
cell adhesion.BCECF-AM–labeled NCI-H929 cells were preincubated in medium without (Nil) and
with pertussis toxin (PTx) (200 ng/mL, 2 hours) (A) or with cytochalasin ...
Francisco Sanz-Rodrı́guez et al. Blood 2001;97:346-351
©2001 by American Society of Hematology
Activation of the p44/42 MAP kinase by SDF-1α is not required for the up-regulation of VLA-4–
mediated cell adhesion.(A) NCI-H929 cells were pre-incubated in the absence or in the presence
of PD98059 before the addition of SDF-1α (100 ng/mL) for the indicate...
Francisco Sanz-Rodrı́guez et al. Blood 2001;97:346-351
©2001 by American Society of Hematology
Effect of inhibitors of phosphatidylinositol 3-kinase on SDF-1α–up-regulated VLA-4–dependent
myeloma cell adhesion and chemotaxis.(A) BCECF-AM–labeled NCI-H929 cells were treated for
30 minutes in adhesion medium without (Nil) or with wortmannin (Wort) (0.2...
Francisco Sanz-Rodrı́guez et al. Blood 2001;97:346-351
©2001 by American Society of Hematology
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