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Download 766-771 May 9, 2017
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X-ray crystal structure of plasmin with tranexamic acid– derived active site inhibitors by Ruby H. P. Law, Guojie Wu, Eleanor W. W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, and James C. Whisstock BloodAdv Volume 1(12):766-771 May 9, 2017 © 2017 by The American Society of Hematology Ruby H. P. Law et al. Blood Adv 2017;1:766-771 © 2017 by The American Society of Hematology Crystal structure of μPlm inhibitor binary complexes. Ruby H. P. Law et al. Blood Adv 2017;1:766-771 © 2017 by The American Society of Hematology Inhibitor binding to Plm determined by NMR. (A) Saturation-transfer difference (STD) spectra reveal binding of TXA to μPlm. Ruby H. P. Law et al. Blood Adv 2017;1:766-771 © 2017 by The American Society of Hematology Inhibition of Plm enzyme activity by TXA and lysine. Ruby H. P. Law et al. Blood Adv 2017;1:766-771 © 2017 by The American Society of Hematology Impact of YO compounds on Plg conformation. Ruby H. P. Law et al. Blood Adv 2017;1:766-771 © 2017 by The American Society of Hematology
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