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A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 by Minyun Zhou, Xianchi Dong, Carsten Baldauf, Hua Chen, Yanfeng Zhou, Timothy A. Springer, Xinping Luo, Chen Zhong, Frauke Gräter, and Jianping Ding Blood Volume 117(17):4623-4631 April 28, 2011 ©2011 by American Society of Hematology Structure of ssA2. Minyun Zhou et al. Blood 2011;117:4623-4631 ©2011 by American Society of Hematology Force-probe MD simulations of a wtA2 model with or without a Ca2+ bound at the metal-binding site. Minyun Zhou et al. Blood 2011;117:4623-4631 ©2011 by American Society of Hematology Effect of Ca2+ binding on A2 cleavage by ADAMTS13. Minyun Zhou et al. Blood 2011;117:4623-4631 ©2011 by American Society of Hematology Effect of mutations at the Ca2+-binding site on A2 cleavage by ADAMTS13. Minyun Zhou et al. Blood 2011;117:4623-4631 ©2011 by American Society of Hematology