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ORGAN PROTECTION
INTERVENTIONS FOR MACROVASCULAR RISK REDUCTION
Risk Factor
Goal
Smoking
Cessation, using counseling or
medications
Obesity
Weight Reduction by:
Exercise: 30 – 60 minutes of moderate
intensity aerobic exercise at least 3 times
per week
Diet: Fat of <30% total calories with <7%
saturated fat and <1% trans fat; sodium
restriction
Hypertension
Blood Pressure of <130/80mmHg
Dyslipidemia
TG <150mg/dL
High Risk Patients:
LDL <70mg/dL
Non-HDL <100mg/dL
Apo B <80mg/dL
Non-High Risk Patients:
LDL <100mg/dL
Non-HDL <130mg/dL
Apo B <90mg/dL
INTERVENTIONS FOR MACROVASCULAR RISK REDUCTION-CONTD
Hyperglycemia
HbA1C <7%
Hypercoagulability/Dysfibrinolysis
Aspirin primary prevention in high risk
patients*
Secondary prevention in patients with
cardiovascular disease
Inflammation
High-sensitivity C-reactive protein
<2mg/L**
PROTECTION OF KIDNEYS
Complication
Method
Frequency
Optimal Goals
Nephropathy
Urine Microalbumin
Annually*
Albumin
<30mg/24hr or
Albumin- Creatinine
ratio<30mg/g in
random urine
specimen
GFR estimation by
serum creatinine
Annually
GFR > 90
mL/min/1.72m2
DIABETIC RETINOPATHY


Diabetic retinopathy is a complication from diabetes
that affects the eyes. It sometimes leads to partial
vision loss and eventually results in blindness. The
leading cause of blindness in adults, diabetic
retinopathy is caused by damage to or swelling of the
blood vessels in the back of the eye (the retina), which
is constructed of light-sensitive tissue. In some cases,
blood vessels can leak fluid into the eye's macula
causing blurred vision. In other cases, new blood
vessels grow abnormally, attaching to the surface of
the retina. Anyone with type 1 or type 2 diabetes is at
risk but especially longtime diabetics and those with
less controlled blood sugar levels.
PROTECTION FOR EYES
Complication
Method
Retinopathy
Regular eye check
ups
Dilated and
comprehensive eye
exam
Frequency
Optimal Goals
Initially
Type 1: 3–5 years
after onset
Type 2: From
diagnosis
Annually; more
frequently if
pregnant or
progressive
retinopathy
Primary prevention,
delay of progression
and prevention of
blindness from
retinopathy
NEUROPATHY
Complication
Method
Frequency
Optimal Goals
Neuropathy
Daily self-inspection
of feet
Every visit
Intact skin
Comprehensive foot
examination
Annually
Normal examination
Examination for
distal symmetric
polyneuropathy
At diagnosis and
annually
Early detection and
limb preservation
Assessment for
autonomic
neuropathy
Type 1: 5 years after
diagnosis
Type 2: from
diagnosis
Early detection,
symptom control,
recognition of
associated
cardiovascular risk