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Download (rbc introduction strip sequence) Gulf Coast 2013
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Erythropoietin (EPO) binds to Erythropoietin Receptor (EPO-R) on Erythrocyte Progenitor Cells Erythropoietin (EPO) binding induces conformational changes to occur in Erythropoietin Receptor (EPO-R) Activation of Janus Kinase (JAK) occurs Janus Kinase (JAK) activates its substrate, STAT5, a transcription factor Activated STAT5 translocates into the nucleus STAT5 binds to promoter elements of proliferation-inducing genes Expression of proliferation-inducing genes Increased production of Red Blood Cells
