Download Supplementary Table 2. Conserved alterations in the basal gene

Supplementary Table 2. Conserved alterations in the basal gene expression levels of
radiation sensitive primary human fibroblasts
Gene ontology group
Sequence Name
Accession #
Response to DNA damage
DDIT4
NM_019058
Programmed cell death
PDCD5
NM_004708
ANGPTL4
NM_139314
TP53I3
NM_004881
SULF1
NM_015170
UNC5B
NM_170744
NUDT2
NM_001161
SGK
NM_005627
Regulation of cell cycle
NM_015714
NM_015714
NM_006455
NM_006455
AK130930
AK130930
Regulation of cell proliferation and growth
TOB1
NM_005749
NOV
NM_002514
CYR61
NM_001554
WARS
NM_004184
ADAMTS1
NM_006988
CSRP2
NM_001321
Defense response
DF
NM_001928
Z33459
Z33459
BC020891
BC020891
MICA
NM_000247
IFITM3
NM_021034
HLA-F
NM_018950
C2
NM_000063
NM_015892
NM_015892
X56841
X56841
SERPING1
NM_000062
CRLF1
NM_004750
HLA-B
NM_005514
ADA
NM_000022
Intracellular signaling cascade
ADAM9
NM_003816
RASSF2
NM_014737
TENS1
NM_022748
PRKAR1A
NM_002734
AK027294
AK027294
Cell surface receptor linked signal transduction
GNG11
NM_004126
AL162032
AL162032
FZD2
NM_001466
AGT
NM_000029
GPR124
NM_032777
NM_017526
NM_017526
Fold Change
-2.01
Sequence Description
DNA-damage-inducible transcript 4 (DDIT4),
+1.585
+1.93
-1.62
-3.71
-2.995
-1.62
-1.76
programmed cell death 5 (PDCD5),
angiopoietin-like 4, transcript variant 1,
tumor protein p53 inducible protein 3
sulfatase 1 (SULF1),
unc-5 homolog B (C. elegans) (UNC5B),
nucleoside diphosphate linked moiety-type motif 2
serum/glucocorticoid regulated kinase (SGK),
-3.105
-2.48
-1.74
putative lymphocyte G0/G1 switch gene (G0S2),
synaptonemal complex protein SC65 (SC65),
cDNA FLJ27420 fis, clone WMC07143
+1.58
+2.555
-3.22
-1.435
-1.615
-2.335
transducer of ERBB2, 1 (TOB1),
nephroblastoma overexpressed gene (NOV),
cysteine-rich, angiogenic inducer, 61 (CYR61),
Unknown
metalloprotease with thrombospondin type 1 motif
cysteine and glycine-rich protein 2 (CSRP2),
-2.455
-2.955
-1.595
-1.71
-1.68
-2.28
-1.55
-3.3
-1.53
-2.785
-3.305
-2.355
-1.635
D component of complement (adipsin) (DF),
H.sapiens for MHC class I HLA-C allele
Homo sapiens, clone IMAGE:4694038,
MHC class I polypeptide-related sequence A
interferon induced transmembrane protein 3
major histocompatibility complex, class I, F
complement component 2 (C2),
B cell RAG associated protein
H.sapiens HLA-E gene
serine (or cysteine) proteinase inhibitor, clade G,
cytokine receptor-like factor 1 (CRLF1),
major histocompatibility complex, class I, B
Unknown
+1.295
+2.21
-2.015
-1.49
-1.915
a disintegrin and metalloproteinase domain 9
Ras association domain family 2 variant
tensin-like SH2 domain containing 1 (TENS1),
Unknown
cDNA FLJ14388 fis, clone HEMBA1002716
+1.66
-2.62
-1.6
-7.53
-2.085
-1.745
G protein, gamma 11
cDNA DKFZp434B1272
frizzled homolog 2 (Drosophila) (FZD2),
angiotensinogen proteinase inhibitor,
G protein-coupled receptor 124 (GPR124),
leptin receptor gene-related protein (OBRGRP),
Gene ontology group
Sequence Name
Accession #
Fold Change
Protein metabolism
PAM
NM_000919
RPS4Y
NM_001008
DNAJD1
NM_013238
RPS4Y2
NM_138963
OXA1L
NM_005015
AK074645
AK074645
NM_007173
NM_007173
CPZ
NM_003652
SULF2
NM_018837
FBXO32
NM_058229
BLMH
NM_000386
CTSF
NM_003793
ADAMTS2
NM_014244
ADAM12
NM_003474
PGRMC2
NM_006320
X75311
X75311
MMP11
NM_005940
BC026270
BC026270
AF419616
AF419616
EEF2
NM_001961
SIAT4A
NM_003033
MMP14
NM_004995
Nucleotide, nucleic acid metabolism
NR0B1
NM_000475
BHLHB3
NM_030762
ACYP2
NM_138448
TALDO1
NM_006755
AB058765
AB058765
PYCR1
NM_153824
U2AF1L2
NM_005089
Generation of precursor metabolites and energy
MT1X
NM_005952
PC
NM_000920
GAA
NM_000152
NXN
NM_022463
Cell communication
NPTX1
NM_002522
AL133035
AL133035
AL359062
AL359062
LAMB3
NM_000228
COL8A1
NM_001850
DPT
NM_001937
GLUL
NM_002065
Cell-cell adhesion
CDH13
NM_001257
BX648591
BX648591
CD36
NM_000072
Y11711
Y11711
Oxygene and reactive oxygene species metabolism
OSR1
NM_005109
Sequence Description
+2.53
+2.47
+1.56
+2.42
-1.82
-3.625
-1.55
-4.08
-2.62
-1.92
-1.815
-1.865
-1.885
-2.22
-1.56
-1.86
-1.8
-1.875
-1.775
-4.455
-1.695
-2.47
peptidylglycine alpha-amidating monooxygenase
ribosomal protein S4, Y-linked (RPS4Y),
DnaJ (Hsp40) homolog, subfamily D, member 1
ribosomal protein S4, Y-linked 2 (RPS4Y2),
oxidase (cytochrome c) assembly 1-like
cDNA FLJ90164 fis,
protease, serine, 23 (SPUVE),
carboxypeptidase Z (CPZ),
sulfatase 2 (SULF2), transcript variant 1,
F-box only protein 32, transcript variant 1,
bleomycin hydrolase (BLMH),
cathepsin F (CTSF),
metalloprotease with thrombospondin motif
metalloproteinase domain 12, transcript variant 1,
progesterone receptor membrane component 2
Hepatitis B virus fusion for mevalonate kinase
matrix metalloproteinase 11
phosphodiesterase 4D interacting protein
clone DKFZp564A057 AG02 , partial cds
eukaryotic translation elongation factor 2 (EEF2),
sialyltransferase 4ª, transcript variant 1,
matrix metalloproteinase 14 (membrane-inserted)
+2.15
+2.095
+1.56
-1.38
-2.285
-1.47
-1.54
nuclear receptor subfamily 0, group B, member 1
basic helix-loop-helix domain containing, class B
acylphosphatase 2, muscle type (ACYP2),
transaldolase 1 (TALDO1),
for KIAA1862 protein, partial cds
pyrroline-5-carboxylate reductase 1
small nuclear RNA auxiliary factor 1-like 2
+1.92
-1.56
-1.585
-2.805
metallothionein 1X (MT1X),
pyruvate carboxylase, transcript variant A,
glucosidase, alpha; acid
nucleoredoxin (NXN),
+4.255
-1.755
-2.205
-2.35
-2.765
-1.805
-1.655
neuronal pentraxin I (NPTX1),
cDNA DKFZp434G171
cDNA clone EUROIMAGE 1913076
laminin, beta 3 (LAMB3),
collagen, type VIII, alpha 1, transcript variant 1,
dermatopontin (DPT),
glutamate-ammonia ligase (glutamine synthase)
+1.98
+2.365
+2.285
+1.575
cadherin 13, H-cadherin (heart) (CDH13),
cDNA DKFZp686G14198
CD36 antigen
extracellular matrix protein collagen type XIV
+1.40
oxidative-stress responsive 1 (OSR1),
2
Gene ontology group
Sequence Name
Transport
SLC20A2
KCNJ2
SLC16A3
NPC1
SLC12A7
C1QTNF5
COL4A1
PTGDS
Organic acid metabolism
CPT1C
SEPHS2
Lipid metabolism
RARRES2
DHCR7
Not-annotated
TMEM16C
MT2A
DDX3Y
DDX3X
BX460058
AF085871
PDGFRL
SERPINE2
BC007034
D50683
AL133052
A_24_P238386
FJX1
AL133118
A_32_P56415
ETHE1
BX640636
CWF19L1
MOXD1
AB002384
C6orf139
PLA2G4A
TFPI
THC1945691
SVIL
NM_016448
LMO2
BG436185
RTN3
SEC3L1
BC043603
FAM29A
ENST00000308092
THC1869247
BM550834
A_32_P225328
Accession #
Fold Change
Sequence Description
NM_006749
NM_000891
NM_004207
NM_000271
NM_006598
NM_015645
NM_001845
NM_000954
+1.73
+1.775
-2.45
-1.51
-1.43
-2.46
-1.905
-2.895
solute carrier family 20 (phosphate transporter),
potassium inwardly-rectifying channel, subfamily
solute carrier family 16, member 3
Niemann-Pick disease, type C1 (NPC1),
solute carrier family 12, member 7
C1q and tumor necrosis factor related protein 5
collagen, type IV, alpha 1 (COL4A1),
prostaglandin D2 synthase 21kDa (brain)
NM_152359
NM_012248
-1.605
-1.635
carnitine palmitoyltransferase 1C (CPT1C),
selenophosphate synthetase 2 (SEPHS2),
NM_002889
NM_001360
-10.785
-1.66
retinoic acid receptor responder
7-dehydrocholesterol reductase (DHCR7),
NM_031418
NM_005953
NM_004660
NM_024005
BX460058
AF085871
NM_006207
NM_006216
BC007034
D50683
AL133052
A_24_P238386
NM_014344
AL133118
A_32_P56415
NM_014297
BX640636
NM_018294
NM_015529
AB002384
NM_018132
NM_024420
NM_006287
THC1945691
NM_021738
NM_016448
NM_005574
BG436185
NM_006054
NM_018261
BC043603
NM_017645
ENST00000308092
THC1869247
BM550834
A_32_P225328
+4.55
+1.915
+2.34
+1.72
+1.865
+1.855
+2.39
+1.87
+2.34
+1.935
+1.655
+2.45
+1.89
+3.91
+2.095
+1.415
+1.525
+1.45
+1.805
+2.76
+2.005
+1.655
+1.705
+2.09
+1.885
+2.25
+1.47
+2.1
+1.41
+1.325
+1.85
+1.43
+1.98
+1.705
+1.76
+3.05
transmembrane protein 16C (TMEM16C),
metallothionein 2A (MT2A),
DEAD box polypeptide 3, Y-linked
DEAD box polypeptide 3, X-linked
Unknown
full length insert cDNA clone YO11A01
platelet-derived growth factor receptor-like
serine (or cysteine) proteinase inhibitor member 2
metallothionein 2A,
TGF-betaIIR alpha, complete cds
cDNA DKFZp434G2415
Unknown
four jointed box 1 (Drosophila) (FJX1),
cDNA DKFZp586N0121
Unknown
ethylmalonic encephalopathy 1 (ETHE1),
cDNA DKFZp779H2259
CWF19-like 1, cell cycle control (S. pombe)
monooxygenase, DBH-like 1 (MOXD1),
for KIAA0386 gene, partial cds
chromosome 6 open reading frame 139
phospholipase A2, group IVA
tissue factor pathway inhibitor
Unknown
supervillin (SVIL), transcript variant 2,
RA-regulated nuclear matrix-associated protein
LIM domain only 2 (rhombotin-like 1)
Unknown
reticulon 3 (RTN3), transcript variant 1,
SEC3-like 1 (S. cerevisiae), transcript variant 1,
Similar to hypothetical protein FLJ33215
family with sequence similarity 29, member A
Unknown
Unknown
Unknown
Unknown
3
Gene ontology group
Sequence Name
IL13RA2
NR_000039
PSG6
AK092921
CENTB2
AK027191
A_24_P254933
A_24_P101426
NM_032762
NM_025268
IL11RA
XM_290732
PLXND1
A_24_P357933
ENST00000333397
A_24_P323805
AK097672
AK128746
THC1858543
ST5
NM_178507
CNN1
A_24_P50666
AK074565
EFEMP1
ADFP
THC1941864
D90278
THC1914497
ACTG2
AK022020
PSG1
ENST00000330895
AK000900
NM_173638
PCOLCE
BC032042
BAMBI
SMPDL3A
THC1857957
PSG2
ENST00000243927
ENST00000322312
A_24_P144163
A_24_P341006
A_23_P370707
ENST00000330704
ENST00000325265
NM_024600
ACTA2
THC1805416
THC1891770
Accession #
NM_000640
NR_000039
NM_002782
AK092921
NM_012287
AK027191
A_24_P254933
A_24_P101426
NM_032762
NM_025268
NM_147162
XM_290732
NM_015103
A_24_P357933
ENST00000333397
A_24_P323805
AK097672
AK128746
THC1858543
NM_005418
NM_178507
NM_001299
A_24_P50666
AK074565
NM_004105
NM_001122
THC1941864
D90278
THC1914497
NM_001615
AK022020
NM_006905
ENST00000330895
AK000900
NM_173638
NM_002593
BC032042
NM_012342
NM_006714
THC1857957
NM_031246
ENST00000243927
ENST00000322312
A_24_P144163
A_24_P341006
A_23_P370707
ENST00000330704
ENST00000325265
NM_024600
NM_001613
THC1805416
THC1891770
Fold Change
+2.05
-1.745
-3.815
-1.65
-1.34
-3.005
-1.77
-1.41
-2.35
-1.72
-1.73
-2.43
-1.465
-1.36
-1.57
-1.4
-7.275
-1.53
-4.285
-1.5
-1.9
-2.59
-2.175
-2.39
-4.14
-1.655
-2.7
-2.385
-1.93
-4.575
-1.615
-3.63
-2.99
-1.48
-1.695
-3.195
-1.575
-2.31
-3.255
-2.505
-2.53
-1.595
-2.675
-1.5
-1.37
-2.235
-1.705
-1.355
-1.73
-2.185
-3.435
-1.93
4
Sequence Description
interleukin 13 receptor, alpha 2 (IL13RA2),
RAB9, member RAS oncogene family,
pregnancy specific beta-1-glycoprotein 6
cDNA FLJ35602 fis,
centaurin, beta 2 (CENTB2),
cDNA: FLJ23538 fis
Unknown
Unknown
hypothetical protein MGC16121
hole gene (MGC4659),
interleukin 11 receptor, alpha, transcript variant 2
KIAA1917 protein (KIAA1917),
plexin D1 (PLXND1),
Unknown
Unknown
Unknown
cDNA FLJ40353 fis,
cDNA FLJ44672 fis, clone BRACE3006553
Unknown
Unknown
NS5ATP13TP2 protein
calponin 1, basic, smooth muscle (CNN1),
Unknown
cDNA FLJ90084 fis,
fibulin-like extracellular matrix protein 1
adipose differentiation-related protein (ADFP),
Unknown
CGM1b for CD66d, complete cds
Unknown
actin, gamma 2, smooth muscle, enteric
cDNA FLJ11958 fis, clone HEMBB1000996
pregnancy specific beta-1-glycoprotein 1
Unknown
cDNA FLJ10038 fis, clone HEMBA1000971
hypothetical protein MGC8902
procollagen C-endopeptidase enhancer
polyadenylation specific factor 6,
BMP membrane-bound inhibitor homolog
sphingomyelin phosphodiesterase, acid-like 3A
Unknown
pregnancy specific beta-1-glycoprotein 2
similar to X-linked ribosomal protein 4
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
hypothetical protein FLJ20898 (FLJ20898),
actin, alpha 2, smooth muscle, aorta (ACTA2)
Unknown
Unknown
Gene ontology group
Sequence Name
AY040873
BC062438
AL137500
CEACAM7
FBLN1
MAGED4
COL4A2
NM_020190
A_23_P125109
A_23_P211468
LTB4DH
A_24_P195510
ENST00000293569
A_24_P366768
ACTN1
THC1957039
BC035647
AL137734
NM_022480
THC1822857
PSG4
ENST00000308589
AK090500
MARCKS
Accession #
AY040873
BC062438
AL137500
NM_006890
NM_001996
NM_030801
NM_001846
NM_020190
A_23_P125109
A_23_P211468
NM_012212
A_24_P195510
ENST00000293569
A_24_P366768
NM_001102
THC1957039
BC035647
AL137734
NM_022480
THC1822857
NM_002780
ENST00000308589
AK090500
NM_002356
Fold Change
-1.88
-2.63
-1.985
-2.895
-3.245
-2.84
-3.06
-2.03
-1.985
-1.67
-1.87
-1.635
-2.47
-1.38
-1.72
-1.635
-2.485
-2.5
-1.535
-2.79
-2.42
-1.63
-1.645
-1.725
Sequence Description
C21orf57 isoform A protein
cDNA clone IMAGE:6494968
cDNA DKFZp761F171
carcinoembryonic antigen-related molecule 7
fibulin 1 (FBLN1), transcript variant C,
melanoma antigen, family D,
collagen, type IV, alpha 2 (COL4A2),
olfactomedin-like 3 (OLFML3),
Unknown
Unknown
leukotriene B4 12-hydroxydehydrogenase
Unknown
DJ377H14
Unknown
actinin, alpha 1 (ACTN1),
Unknown
Homo sapiens, clone IMAGE:5575764,
cDNA DKFZp586C0721
hypothetical protein FLJ12587
Unknown
Unknown
Unknown
similar to HLA classI histocompatibilty antigene
myristoylated alanine-rich protein kinase C substr
________________________________________________________________
The expression of these genes was altered on all arrays. The fold expression changes
represent the mean value of the arrays, the deviation is < +/-0.4. The + and – marks show upand down-regulated genes, respectively.
5