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Curriculum Vitae (2012) McLaughlin, Kelly A. Kelly A. McLaughlin, Ph.D. Associate Professor of Biology & Biology Graduate Program Director 163 Packard Ave.; 120 Dana Hall Medford, MA 02155 Office: (617) 627-4154 [email protected] KELLY A. MCLAUGHLIN email: [email protected] EDUCATION 1996-2001 Postdoctoral Fellow Harvard Medical School, Department of Cell Biology, Boston, MA 1998 Developmental Biology Teaching Workshop Darling Marine Center, University of Maine, Walpole, ME 1990-1996 Ph.D. Molecular and Cellular Biology University of Massachusetts, Amherst, MA 1986-1990 B.A. Biology (major)/Chemistry (minor) Wheaton College, Norton, MA RESEARCH EXPERIENCE Associate Professor 2007-present Tufts University, Department of Biology, Medford, MA appointment without limit of time Research: Mechanisms used to create the embryonic organs Organogenesis: Development, Regeneration, and Remodeling Assistant Professor 2001-2007 Tufts University, Department of Biology, Medford, MA Postdoctoral Fellow 1996-2001 Harvard Medical School, Department of Cell Biology, Boston, MA P.I. Dr. Mark Mercola Role of Notch signaling in Xenopus organogenesis Graduate Student 1990-1996 Univ. of Massachusetts, Department of Molecular and Cell Biology P.I. Dr. Barbara Osborne Identification of mechanisms involved in murine thymocyte apoptosis TEACHING EXPERIENCE Associate Professor 2007-present Assistant Professor 2001-2007 Adjunct Faculty fall 1998- 2001 Tufts University, Medford, MA Courses Taught: • Developmental Biology BIO103 • Cell Signaling: Life, Death, and Disease BIO182 • Experiments in Cell Biology BIO52 • Cells and Organisms BIO13L • Molecular Nephrology BIO196; Eco-Development BIO196 • Science and the media: the fact behind the fiction (TAS) • The Other Side of Science (workshop) • Teaching Biology: Pedagogy and Practice BIO260 • Teaching in diverse settings – labs and lectures (GIFT) Harvard University, Cambridge, MA Principles of Developmental Biology (fall), Harvard Extension School 1 Curriculum Vitae (2012) McLaughlin, Kelly A. TEACHING AWARDS NRC/HHMI National Academies Education Fellow in the Life Sciences summer 2008 The National Academies/HHMI Summer Institutes on Undergraduate Education in Biology sponsored by the HHMI and the National Academies. Tufts University Undergraduate Initiative in Teaching Award (UNITE 2006) spring 2006 Awarded to: “Junior full-time faculty member who has demonstrated excellence in teaching & advising, concern for students’ academic and personal growth, and the ability to convey a passion and enthusiasm for their field of study.” Harvard College Certificate of Distinction in Teaching Award (Derek Bok Center) spring 1998 Awarded to: “recipients that have achieved 4.5 or above on the CUE evaluation's 5point scale, with at least 7 respondents from a section.” University of Massachusetts Excellence in Teaching Award, Teaching Assistant spring 1991 Awarded to: “A graduate student Teaching Assistant that has improved undergraduate education through mentoring and implementation of novel teaching initiatives designed to enhance the classroom experience.” GRANTS AND FELLOWSHIPS AWARDED 2009-2013 2008-2009 2006-2007 2003-2007 2003-2006 2000-2002 2000-2001 1997-2000 National Science Foundation, (BIO/IOS) NRC/HHMI Summer Institute Fellowship FRAC-Marshall Research Award, Tufts University, MA American Heart Association (National) - Scientist Development Grant American Heart Association (Northeast) - Scientist Development Grant National Kidney Foundation Fellowship Bunting Fellowship; Radcliffe for Advanced Study, Harvard University National Research Service Award, National Institutes of Health REPRESENTATIVE HONORS AND OUTREACH ACTIVITIES (2001-present) March 2011 Feb. 2011 Oct. 2010 Sept. 2010 Sept. 2008 Nov. 2006 Oct. 2006 April 2006 April 2006 April 2005 March 2005 2005-pres. Aug. 2004 May 2004 April 2003 March 2003 Dec. 2002 April 2002 Key Note Speaker Schulman lecture series, Wheaton College, MA Invited participant, Biology Assessment Writing Workshop, Boston MA IRACDA Conference Panelist, Tufts Med. School, Boston, MA Invited speaker,13th International Xenopus Conference, Lake Louise, Canada Invited speaker, NEBAALAS, Harvard Medical School, Boston, MA Invited speaker, American Heart Association, Cardiology conference, Chicago Invited speaker, University of Massachusetts, Amherst, MA Invited speaker, High Table Dinner Series, Tufts University, Medford, MA Invited speaker, April Open House Tufts University, Medford, MA Invited speaker and session organizer (co-chair), SDB Northeast meeting, MA Invited speaker, Boston University Medical School, Boston, MA Participant, Teachers as Scholars Program, hosted at Tufts University, Medford Participant, Lexington High School METCO program, hosted at Tufts, Medford, Invited speaker, Tufts Medical School, Boston, MA Invited speaker, Grinnell College, Howard Hughes Program, Iowa, IA Invited speaker, Forsyth Institute, Harvard Medical School, Boston, MA Invited speaker, Waltham High School, Waltham, MA Invited Key Note Speaker, Boston University, Pathways Program , Boston, MA 2 Curriculum Vitae (2012) 2000-2002 April 2001 1998-present McLaughlin, Kelly A. Participant, Pathways Program, Boston University, MA Invited Speaker, Radcliffe Institute for Advanced Study, Cambridge, MA State High School Science Fair Judge, Massachusetts Institute of Technology SELECTED PUBLICATIONS in Refereed journals (Full articles) (*denotes undergraduate author) 1) Caine, S.T. and McLaughlin, K.A. Restoration of functional pronephric proximal tubules after mechanical renal damage in Xenopus laevis. (fall 2012 under revision) 2) Lenkowski, J. R., Sanchez-Bravo, G.* and McLaughlin, K. A. (2010) Low concentrations of atrazine, glyphosate, 2,4-dichlorophenoxyacetic acid (2,4-D), and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis. J. Environ. Sci. 22 (9): 1305-8. 3) Lenkowski, J. R. and McLaughlin, K. A. (2010) Acute atrazine exposure disrupts matrix metalloproteinases and retinoid signaling during organ morphogenesis in Xenopus laevis Journal of Applied Toxicology. 30(6) 582-589. DOI: 10.1002/jat.1529 4) Blackiston, D.J., McLaughlin, K., and Levin, M. (2009) Bioelectric controls of cell proliferation: Ion channels, membrane voltage, and the cell cycle. Cell Cycle. 8(21) 1-10. (Cover) 5) Miazga, C. and McLaughlin, K.A., (2009) Coordinating the timing of cardiac precursor cell development during gastrulation: a new role for Notch signaling. Developmental Biology. 333(2) 285–296. 6) Lenkowski, J., Reed, J.M., Deininger, L.*, and McLaughlin, K.A. (2008) Perturbation of Organogenesis by the Herbicide Atrazine in the Amphibian Xenopus laevis. Environmental Health Perspectives 116:223-230 (published online Nov. 22, 2007). 7) Bracken, C., Mizeracka, K.*, and McLaughlin, K.A. (2008) Patterning the embryonic kidney: BMP signaling mediates the differentiation of the pronephric tubules and duct. Developmental Dynamics 237:132–144 (published online Dec. 10, 2007). 8) Contakos, S.P., Gaydos, C., Pfeil, E.C.*, and McLaughlin, K.A. (2005) Subdividing the embryo: a role for Notch signaling during germ layer patterning in Xenopus laevis. Developmental Biology 288(1):294-307. 9) Van Stry, M., McLaughlin, K.A., Ataliotis, P., and Symes, K. (2004) The mitochondrial-apoptotic pathway is triggered in Xenopus mesoderm cells deprived of PDGF receptor signaling during gastrulation. Developmental Biology 268(1):232242. 3 Curriculum Vitae (2012) McLaughlin, Kelly A. 10) Tonomura, N., McLaughlin, K.A., Grimm, L., Goldsby, R.A., and Osborne, B.A. (2003) Glucocorticoid-induced Apoptosis of Thymocytes: Requirement of Proteasome Dependent Mitochondrial Activity. Journal of Immunology 170(5):2469-2478. 11) Rones, M.S., Woda, J., Mercola, M., and McLaughlin, K.A. (2002) Isolation and Characterization of Xenopus Hey-1: A Downstream Mediator of Notch Signaling. Developmental Dynamics 225:554-560. 12) McLaughlin, K.A., Rones, M.S., and Mercola, M. (2000) Notch regulates cell fate in the developing pronephros. Developmental Biology 227:567-580. 13) Rones, M.S., McLaughlin, K.A., Raffin, M., and Mercola, M. (2000) Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127:3865-3876. 14) McLaughlin, K.A., Osborne, B.A., and Goldsby, R.A. (1996) The role of oxygen in thymocyte apoptosis. European Journal of Immunology 26:1170-1175. 15) Osborne, B.A., Smith, S., McLaughlin, K.A., Grimm, L., Morgan, G., and Goldsby, R.A. (1996) Genetic regulation of apoptosis in the mouse thymus. Mechanisms of Lymphocyte Activation and Immune Regulation. Plenum press In Advances in Experimental Medicine and Biology. Vol. 406:199-208. 16) McLaughlin, K.A., S.W. Smith, C.E. Milligan, W. Bielke, L.M. Schwartz, and B.A. Osborne. (1995) The isolation and characterization of cell death genes. In: Handbook of Experimental Immunology, Blackwell Scientific Press, Vol. 4; Ch. 126:1-14. 17) Osborne, B.A., Smith, S., McLaughlin, K.A., Grimm, L., and Schwartz, L. (1995) Genes that regulate apoptosis in the mouse thymus. Journal of Cellular Biochemistry 60:18-22. 18) Smith, S., McLaughlin, K.A., and Osborne, B.A. (1995) Molecular events in thymocyte apoptosis death in the thymus. In: Current Topics in Microbiology and Immunology. G. Kroemer and A. Martinez, editors, p. 147-162, Springer-Verlag. 19) Osborne, B.A., S.W. Smith, Z.-G Liu, K. McLaughlin, and L. M. Schwartz. (1995) Transient transfection assays to examine the requirement of putative cell death genes. In: Methods in Cell Biology: Cell Death, Vol. 46:99-106, Academic Press, San Diego, CA. 20) Liu, Z.-G., Smith, S., McLaughlin, K.A., Schwartz, L., and Osborne, B.A. (1994) Apoptotic signals delivered through the T-cell receptor of T-cell hybrid require the immediate-early gene nur77. Nature 367:281-284. 21) Osborne, B.A., S.W. Smith, Z.-G. Liu, K. McLaughlin, L. Grimm, and L.M. Schwartz. (1994) Identification of genes induced during apoptosis in T lymphocytes. Immunological Reviews, Vol. 141:301-320. 4 Curriculum Vitae (2012) McLaughlin, Kelly A. EXAMPLES OF PUBLISHED ABSTRACTS (2001-present) (* denotes undergraduate author) 1) Caine, S.T. and McLaughlin, K.A. (2012) Elucidating the mechanism of proximal tubule regeneration in the pronephros Xenopus laevis tadpoles. Developmental Biology. 368 (1): 140. 2) Shoshoni Caine and Kelly A. McLaughlin. (2011) Characterizing the cellular process of renal repair in the Xenopus laevis pronephric kidney. Developmental Biology 356 (1): 220. 3) Shoshoni Caine and Kelly A. McLaughlin. (2010) The role of matrix metalloproteinases in the repair of the Xenopus laevis pronephric kidney. Developmental Biology. 344(1) 520. 4) Shoshoni Caine and Kelly A. McLaughlin. (2009) Restoration of the pronephric kidney in Xenopus laevis tadpoles. Developmental Biology. 331(2) 488. 5) Patrick T. McMillen*, Carolyn M. Gaydos, Ellen S. Moore, Thuy Ivy Vo*, Kelly A. McLaughlin (2007). Creating embryonic tissues: the role of bHLH genes during the prepatterning of the mesoderm in Xenopus laevis. Developmental Biology. 306(1) 412. 6) Christina Bracken, Karolina Mizeracka*, and Kelly A. McLaughlin. (2006). BMP signaling mediates proper formation of the pronephric kidney in Xenopus laevis. Developmental Biology, 295(2):458. 7) Jenny Lenkowski and Kelly A. McLaughlin. (2005). The effects of the widely used herbicide atrazine on early amphibian development. Developmental Biology 283(2):569. 8) Carolyn M. Gaydos and Kelly A. McLaughlin. (2005). A Role for Notch signaling in mesoderm patterning of Xenopus laevis. Developmental Biology 283(2):422. 9) Karolina Mizeracka*, Stefan Wawersik, and Kelly A. McLaughlin. (2004). Role of BMP signaling during the development of the embryonic kidney (pronephros). Developmental Biology 271(2):623. 10) Emily C. Pfeil*, Stacey P. Coleman, and Kelly A. McLaughlin. (2004). Notch signaling influences the early patterning of Xenopus laevis. Developmental Biology 271(2):619. 11) Melanie Van Stry, Kelly A. McLaughlin, and Karen Symes. (2003). Inhibition of PDGF signaling results in apoptosis of mesoderm cells during gastrulation in Xenopus laevis. Developmental Biology 259(2):463. 5 Curriculum Vitae (2012) McLaughlin, Kelly A. 12) Stacey Coleman and Kelly A. McLaughlin. (2003). Subdividing the embryo: A role for Notch signaling. Developmental Biology 259(2):555. 13) Melanie Van Stry, Kelly A. McLaughlin, and Karen Symes. (2002). The role of PDGF signaling during gastrulation in Xenopus laevis. Molecular Biology of the Cell 13:531. 14) Kelly A. McLaughlin, Melissa S. Rones, and Mark Mercola. (2001). The Biology of Becoming: Cell Fate Decisions During Embryonic Kidney Development. Developmental Biology 235(2):151. EXAMPLES OF PRESENTATIONS AT CONFERENCES (2001-pres.) (* denotes undergraduate) 1) Shoshoni Caine and Kelly A. McLaughlin. (2012). Elucidating the mechanism of proximal tubule regeneration in the pronephros Xenopus laevis tadpoles.. Society for Developmental Biology Annual conference. Montreal, Canada (presented by S. Caine). 2) Kelly A. McLaughlin (2011). La Donne Heaton Schulman Science Lecture series, Invited keynote speaker, named lecture series: The biology of becoming: developmental decisions. Wheaton College, Norton, MA. 3) Kelly A. McLaughlin (2011). Curriculum Fellow & Preceptor Retreat, Talk title: Science education, the good the bad the reality. Invited Key Note Speaker: Harvard University, Cambridge MA. 4) Shoshoni Caine and Kelly A. McLaughlin. (2011) Characterizing the cellular process of renal repair in the Xenopus laevis pronephric kidney. (Society for Developmental Biology Annual conference. Chicago, IL (presented by S. Caine). 5) Shoshoni Caine and Kelly A. McLaughlin. (2010) The role of matrix metalloproteinases in the repair of the Xenopus laevis pronephric kidney. Society for Developmental Biology Annual conference. San Francisco, CA (presented by S. Caine). 6) Shoshoni Caine and Kelly A. McLaughlin. (2009) Restoration of the pronephric kidney in Xenopus laevis tadpoles. Society for Developmental Biology Annual conference. San Francisco, CA (presented by S. Caine). 7) Kelly A. McLaughlin. Teaching Biology: Pedagogy and Practice (BIO260) update (Feb. 2009) Howard Hughes Medical Institute, Summer Institute Midterm meeting at HHMI Headquarters, MD. 8) Jenny R. Lenkowski and Kelly A. McLaughlin (2009) Disruption of tissue morphogenesis in pesticide-exposed Xenopus laevis tadpoles. Society for Integrative and Comparative Biology Annual Conference. Boston, MA. (selected talk by J. Lenkowski). 6 Curriculum Vitae (2012) McLaughlin, Kelly A. 9) Jenny R. Lenkowski and Kelly A. McLaughlin (2008) Atrazine exposure disrupts tissue morphogenesis in a model amphibian system. Gordon Research Conference on Environmental Endocrine Disruptors. Waterville Valley, NH. (selected talk by J. Lenkowski). 10) Carolyn M. Gaydos and Kelly A. McLaughlin (2008) Notch signaling regulates cell fate decisions during cardiac field formation in Xenopus laevis. Cardiac Development and Regeneration Conference, Abcam Inc., Boston, MA (selected talk by C. Gaydos). 11) Carolyn M. Gaydos and Kelly A. McLaughlin (2008) Notch Signaling Regulates Cell Fate Decisions During Cardiac Field Formation in Xenopus laevis. Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by C. Gaydos). 12) Shoshoni T. Caine and Kelly A. McLaughlin (2008) Pronephric kidney repair & regeneration in the amphibian Xenopus laevis. Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (selected talk presented by S. Caine). 13) Awarded best poster award: Patrick T. McMillen*, Carolyn M. Gaydos, Ellen S. Moore, Thuy Ivy Vo*, Kelly A. McLaughlin (2007). Creating embryonic tissues: the role of bHLH genes during the prepatterning of the mesoderm in Xenopus laevis. Society for Developmental Biology International Meeting, Cancun Mexico (presented by P. McMillen) 14) Christina M. Bracken and Kelly A. McLaughlin (2007) Patterning the embryonic kidney: BMP signaling mediates differentiation of the pronephric tubules and duct in X. laevis. Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by C. Bracken) 15) Jenny R. Lenkowski* and Kelly A. McLaughlin (2007). Teratogenic effects of a common herbicide on organ morphogenesis in Xenopus laevis Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by J. Lenkowski) 16) Patrick T. McMillen*, Carolyn M. Gaydos, Ellen S. Moore, Thuy Ivy Vo, Kelly A. McLaughlin (2007). Towards an Understanding of the Role of bHLH Genes During Pronephric Patterning in Xenopus laevis Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by P. McMillen*) 17) Multiple roles for Notch signaling during cardiogenesis. (2006). Ellen Moore, Carolyn Gaydos, Patrick McMillen*, and Kelly A. McLaughlin. American Heart Association Scientific Sessions Annual Cardiology Conference, Chicago, IL. (presented by K. McLaughlin) 18) BMP signaling mediates proper formation of the pronephric kidney in Xenopus laevis. (2006). Christina Bracken, Karolina Mizeracka*, and Kelly A. McLaughlin. 7 Curriculum Vitae (2012) McLaughlin, Kelly A. Society for Developmental Biology National Meeting, Ann Arbor, MI. (presented by C. Bracken) 19) The effects of an herbicide on early frog development. (2006). Jenny Lenkowski and Kelly A. McLaughlin. Tufts University Research Days; Shining a Light on Environmental Scholarship, Medford, MA. (presented by J. Lenkowski) 20) Deleterious effects of pesticides on non-target organisms. (2006). Jenny Lenkowski and Kelly A. McLaughlin. Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by J. Lenkowski) 21) Awarded best poster award: A role for notch signaling during heart field specification in Xenopus laevis. (2006). Carolyn Gaydos and Kelly A. McLaughlin. Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by C. Gaydos) 22) The effects of the widely used herbicide atrazine on early amphibian development. (2005). Jenny Lenkowski and Kelly A. McLaughlin. Society for Developmental Biology National Meeting, San Francisco, CA. (presented by J. Lenkowski) 23) A role for notch signaling in mesoderm patterning of Xenopus laevis. (2005). Carolyn M. Gaydos and Kelly A. McLaughlin. Society for Developmental Biology National Meeting, San Francisco, CA. (presented by C. Gaydos) 24) Multiple roles for Notch signaling during formation of mesodermal organs. (2005). Stacey Contakos, Carolyn Gaydos, Emily Pfeil* and Kelly A. McLaughlin. Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by K. McLaughlin) 25) Notch-mediated formation of the mesoderm and endoderm germ layers. (2005). Carolyn M. Gaydos, Stacey Contakos, Emily Pfeil*, and Kelly A. McLaughlin. Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by C. Gaydos) 26) Awarded best poster award: Role of BMP signaling during the development of the pronephros. (2005). Karolina Mizeracka* and Kelly A. McLaughlin. Society for Developmental Biology Northeast Regional Meeting, Woods Hole, MA. (presented by K. Mizeracka*) 27) Role of BMP signaling during the development of the embryonic kidney (pronephros). (2004). Karolina Mizeracka*, Stefan Wawersik, and Kelly A. McLaughlin. Society for Developmental Biology National Meeting, Calgary, Canada. (presented by K. Mizeracka*) 28) Notch signaling influences the early patterning of Xenopus laevis. (2004). Emily C. Pfeil*, Stacey P. Coleman and Kelly A. McLaughlin. Society for Developmental Biology National Meeting, Calgary, Canada. (presented by E. Pfeil*) 29) Inhibition of PDGF signaling results in apoptosis of mesoderm cells during gastrulation in Xenopus laevis. (2003). Melanie Van Stry, Kelly A. McLaughlin, and Karen Symes. Society for Developmental Biology National Meeting, Boston, MA. (presented by M. Van Stry) 8 Curriculum Vitae (2012) McLaughlin, Kelly A. 30) Subdividing the embryo: A role for Notch signaling. (2003). Stacey Coleman and Kelly A. McLaughlin. Society for Developmental Biology National Meeting, Boston, MA. (presented by S. Coleman) 31) Inhibition of PDGFR signaling results in apoptosis of mesoderm cells during gastrulation in Xenopus laevis. (2003). Melanie Van Stry, Kelly A. McLaughlin, Paris Ataliotis, and Karen Symes. Sloan-Ketterning Developmental Biological Inaugural Symposium, New York, NY. (presented by M. Van Stry) 32) Inhibition of PDGF signaling results in apoptosis of mesoderm cells during gastrulation in Xenopus laevis. (2003). Melanie Van Stry, Kelly A. McLaughlin, and Karen Symes. Northeast Regional Meeting, Woods Hole, MA. (presented by M. Van Stry) 33) The role of PDGF signaling during gastrulation in Xenopus laevis. (2002). Melanie Van Stry, Kelly A. McLaughlin, and Karen Symes. American Society for Cell Biology Annual Meeting, San Francisco, CA. (presented by M. Van Stry) 34) The biology of becoming: Cell fate decisions during embryonic kidney development. (2001). Kelly A. McLaughlin, Melissa S. Rones and Mark Mercola. Society for Developmental Biology National Meeting, Seattle, WA. (presented by K. McLaughlin) PROFESSIONAL MEMBERSHIPS Society for Developmental Biology (SDB), member (1997-present ) Annual meeting participant, poster judge (Northeast regional /National) National Kidney Foundation, member (2006-2007) American Heart Association, member (2002-2007 and 2011-present) CIVIC ACTIVITIES (SCIENCE EDUCATION OUTREACH PROGRAMS) State Science Fair Judge (high school) Massachusetts Institute of Technology (1998-present) Teachers as Scholars Program (TAS); professional development program for K-12 teachers (2005-present) a nonprofit, outreach organization designed to give K-12 teachers content-based seminars led by University faculty to give educators an opportunity to discuss and reflect on scholarly issues. Focus on the connection between research and education. Topic is entitled “Science in the Media: the fact behind the fiction” topics include cloning and biotechnology. Mentor/advise local high school students on science fair projects: Some of the public high schools located near Boston do not have the resources or expertise to support their students’ science projects. Dr. McLaughlin (as well as members of her lab) mentor high school students to successfully implement these activities by providing guidance and equipment not available to them in their regular classrooms. (1998-present) The Other Side of Science: This set of workshops is designed to help prepare participants (undergraduate/graduate/postdoctoral) for “life after graduation”. Activities include: C.V. and resume writing, interview skills, database searches, editing and writing, formal & informal presentations (scientific and general audience), project budgets, website design, poster presentations, reading primary literature effectively, requesting reagents (writing a good cover letter), and scientific ethics. Participants include graduate, undergraduate students and postdoctoral fellows working on research projects. 9