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Differential role of hypoxia-inducible factor (HIF)-1α and HIF-2α in vascular development. HIF-1α and HIF-2α have distinct, nonredundant roles in the
formation of the vascular tree. Although endothelial cell proliferation, migration, and vessel sprouting rely more on HIF-1α, HIF-2α plays a larger role in
controlling vascular morphogenesis, integrity, and assembly. HIF-1α also promotes the recruitment of endothelial progenitor cells (EPCs), which physically
constitute the vessel wall, and CD45+ myeloid cells, which release angiogenic cues and matrix proteases. HIF-1α favors pericyte (PC) and smooth muscle
cell (SMC) recruitment, which cover and stabilize the vessels. HIF-1α also regulates the arterial versus venous fate, promoting the formation of arteries.
Reprinted from Fraisl et al.24 Copyright 2010, with permission from Elsevier.
Source: Chapter 8. Biology of the Vessel Wall, Hurst's The Heart, 13e
Citation: Fuster V, Walsh RA, Harrington RA. Hurst's The Heart, 13e; 2011 Available at: http://mhmedical.com/ Accessed: August 03, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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