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Extracellular Matrix Remodeling in Heart Failure
by Karl T. Weber
Circulation
Volume 96(11):4065-4082
December 2, 1997
Copyright © American Heart Association, Inc. All rights reserved.
Overview of interrelationship between structural remodeling of myocardium and ventricular
function in normal and failing hearts.
Karl T. Weber Circulation. 1997;96:4065-4082
Copyright © American Heart Association, Inc. All rights reserved.
Tissue repair in infarcted rat heart induced by permanent left coronary artery ligation.
Karl T. Weber Circulation. 1997;96:4065-4082
Copyright © American Heart Association, Inc. All rights reserved.
Cellular responses seen in serial sections of infarcted rat heart postinfarction.
Karl T. Weber Circulation. 1997;96:4065-4082
Copyright © American Heart Association, Inc. All rights reserved.
Model of reciprocal regulation that involves various stimulators and inhibitors of tissue repair
induced by Ang II. Stimulators include Ang II, TGF-β1, and ET1 and ET3.
Karl T. Weber Circulation. 1997;96:4065-4082
Copyright © American Heart Association, Inc. All rights reserved.
After tissue repair, a complex set of cellular and molecular responses occur to eventuate in
fibrous tissue formation.
Karl T. Weber Circulation. 1997;96:4065-4082
Copyright © American Heart Association, Inc. All rights reserved.
Fibrous tissue is a contractile assembly based on myoFbs having α-SMA and cell-cell
connections via gap junctions and cell-matrix connections via a fibronexus.
Karl T. Weber Circulation. 1997;96:4065-4082
Copyright © American Heart Association, Inc. All rights reserved.
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