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Mitochondrial Dysfunction during Brain Aging: Role of Oxidative Stress
and Modulation by Antioxidant Supplementation
Sasanka Chakrabarti;Soumyabrata Munshi;Kalpita Banerjee;Ishita Guha Thakurta;Maitrayee Sinha;Maria Bindu Bagh;
Department of Biochemistry, Institute of Postgraduate Medical Education and Research, Kolkata, India ;
Figure 2. Redox control of ARE dependent genes. ROS or the redox state of the cell can influence the release of Nrf-2 from inactive Nrf 2-KEAP 1 complex with subsequent
translocation to nucleus and activation of ARE dependent genes. With higher burden of ROS, Nrf 2 binding to DNA is inhibited by the oxidation of a specific cysteine residue.
null,null,2(3),242-256. Doi:null
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