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Transcript 
Growth Arrest–Specific 6 Exacerbates Pressure Overload–
Induced Cardiac HypertrophyNovelty and Significance
by Yi-fan Zhao, Da-chun Xu, Guo-fu Zhu, Meng-yun Zhu, Kai Tang, Wei-ming Li, and
Ya-wei Xu
Hypertension
Volume 67(1):118-129
December 9, 2015
Copyright © American Heart Association, Inc. All rights reserved.
Growth arrest–specific 6 (GAS6) is upregulated in human dilated cardiomyopathy (DCM) hearts,
hypertrophic murine hearts, and cardiomyocytes.
Yi-fan Zhao et al. Hypertension. 2016;67:118-129
Copyright © American Heart Association, Inc. All rights reserved.
Growth arrest–specific 6 (GAS6) cardiac-specific transgenic mice had detrimental effects in
pressure overload–induced cardiac hypertrophy.
Yi-fan Zhao et al. Hypertension. 2016;67:118-129
Copyright © American Heart Association, Inc. All rights reserved.
Growth arrest–specific 6 (GAS6) deficiency ameliorates aortic banding-induced cardiac
hypertrophy.
Yi-fan Zhao et al. Hypertension. 2016;67:118-129
Copyright © American Heart Association, Inc. All rights reserved.
Growth arrest–specific 6 (GAS6) aggravates angiotensin II (Ang II)–induced cardiomyocyte
hypertrophy in vitro.
Yi-fan Zhao et al. Hypertension. 2016;67:118-129
Copyright © American Heart Association, Inc. All rights reserved.
Growth arrest–specific 6 (GAS6) activates mitogen-activated protein kinase kinase 1/2 (MEK1/2)–
extracellular signal-regulated kinase ½ (ERK1/2) during pathological cardiac hypertrophy in vivo
and in vitro.
Yi-fan Zhao et al. Hypertension. 2016;67:118-129
Copyright © American Heart Association, Inc. All rights reserved.
Blockage of mitogen-activated protein kinase kinase 1/2 (MEK1/2)–extracellular signal-regulated
kinase 1/2 (ERK1/2) signaling reverses GAS6-TG–induced detrimental phenotype of cardiac
hypertrophy.
Yi-fan Zhao et al. Hypertension. 2016;67:118-129
Copyright © American Heart Association, Inc. All rights reserved.
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