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Ghasem Ahangari M.T., Ph.D. Associate Professor Current Address: National Institute for Genetic Engineering and Biotechnology (NIGEB), P.O. BOX: 14155- 6343, Tehran, Iran E-mail: [email protected] Tel: (+98) 2144580384 Fax: (+98) 2144580399 Education: 1. B.Sc. degree (1985) in Medical Technology, Iran Medical University, Tehran, IRAN 2. M.S. degree (1988) in Hematology and Blood Banking, Tarbiat Modarrs University, Tehran, IRAN 1 3. Ph.D. degree (1997) in Molecular Clinical Immunology, Tarbiat Modarrs University Tehran, Iran. and Karolinska Institute, Stockholm, Sweden. Professional Experience: 1. Head Department of Immunology at NIGEB (1/2/1998-1/10/ 2002) 2. Member of scientific committee at NIGEB (1/2/1998-1/10/ 2002) 3. Head Department of Medical genetic at NIGEB ( 2008 till now) 4. One-year practical experience in clinic. 5. Two-years practice in Hematology lab. 6. More than 20 years teaching experience for Msc and PhD students in Immunology, Immunogenetic, Immunohematology, Hematology, Blood banking& Transfusion and Medical Biotechnology at Tarbiat Modarres University, Tehran Medical University, Azad University and Rajaie University and National Institute for Genetic Engineering and Biotechnology. 7. Practical Course in analysis of protein structure and function at HEJ Research Center in Karachi, Pakistan (1992). 2 8. Practical course in clinical immunology techniques ( Stem cells and Transplantation) at Erasmus Hospital in Brussels, Belgium (1993). 9. Practical course in Laser Flowcytometry at BD center in Brussels, Belgium (1999). 10. Three years research experience in Molecular Immunology and Immunopathology at Karolinska Institute and Karolinska Hospital in Stockholm, Sweden (19941997). 11. Five years experience as Clinical Immunology lab Director at Sarem Medical Hospital (2000-2004) 12. Chairman and organizer of first practical and theoretical Iranian HLA workshop on molecular diagnosis of HLA in Transplantation, NRCGEB, Tehran, Iran (October, 1999). 13. Director of Private Shademan Clinical Lab (2005-2007) 14. Chairman and organizer of second practical and theoretical Iranian workshop on molecular methods in immunogenetics, NRCGEB, Tehran, Iran (October, 2000). 15. Chairman and organizer of third practical and theoretical Iranian workshop on molecular methods in immunogenetics, NRCGEB, Tehran, Iran (May, 2002). 16. Chairman and organizer of fourth practical and theoretical Iranian workshop on molecular methods in Immunogenetic Tehran, Iran (May, 2003). 17. Chairman and organizer of fifth practical and theoretical Iranian workshop on molecular methods in Immunogenetic Tehran, Iran (October, 2004). 18. Director of Tissue engineering lab, Private Company (1/6/1999- 15/3/2001). 3 19. Chairman and organizer of first practical and theoretical Iranian workshop on Tissue engineering, Tehran, Iran (May, 2006). 20. Supervisor and advisor of 18 Ms and PhD Thesis. 21. Editorial Board of Open Journal of Pathology Publications: 1. Ahangari G., et al. (1996). RT-PCR based analysis of T-cell receptor B variable region gene usage in normal human breast skin resident T lymphocyte (SRT). Scand. J. Immunology. 44, 330. 2. Ahangari G., et al. (1997). RT-PCR topography of chronic psoriasis skin based on analysis of T-cell receptor B variable gene usage, Scand. J. Immunology. 45, 534. 3. Ahangari G., et al. (1997). The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. Journal of biological chemistry.272.24. 15258. 4. Ahangari G., et al. (1998). The presence and clearance of immune complexes in the untreated generalised psoriasis. Inter. J. Immunopathol. Pharmacol. 111. 2. 91. 5. Ahangari G., et al. (1998). RT-PCR based analysis of T-cell receptor B variable region gene usage in nickel allergic contact dermatitis. 10th international congress of immunology. Book. Vol 2. 1190- 1195. 6. Ahangari, G. (1988). Quality and quantitative assay of PBMC before and after induction with mitogen in Hodgkin lymphoma compare to healthy individuals. M.S thesis. 4 7. Ahangari, G. (1997). Immune complex clearance and T cell receptor gene rearrangement on psoriasis patients compare to healthy individuals. PhD thesis. 8. Ahangari G., et al. Immunological mapping of skin immune system based on RT-PCR analysis of TCRBV gene rearrangement (submitted). 9. Ahangari G., et al. (1992). Essential Immunology (I, Roitt). Book, Translated to Persian. 10. Ahangari G., et al.(1999). Molecular diagnosis of HLA in Transplantation, First Iranian Immunogenetic workshop, Booklet, NIGEB, Tehran, Iran. 11. Ahangari G., et al. (2000). Immunogenetic, Second Iranian immunogenetic workshop, Booklet, NIGEB,Tehran, Iran. 12. Ahangari G., et al. (2002). Immunogenetic and clinical application. Third Iranian Immunogenetic workshop, Booklet, NIGEB, Tehran, Iran. 13. Ahangari G, et al. (2003). Immunogenetic (neuroimmunogenetic). Fourth Iranian Immunogenetic workshop, Booklet, NIGEB, Tehran, Iran. 14. Ahangari G, et al. (2003). Immunogenetic . Fifth Iranian Immunogenetic workshop, Booklet, NIGEB, Tehran, Iran. 5 15. Ahangari G. (2003). Tissue Engineering technology (Stem cells, Matrix and Clinical applications), Modern technology in 3th millennium, First Edition, Book, ISBN: 964-7397-16-X, Publisher; Kholous, Tehran, Iran. 16. Ahangari G, et al. (2003). Analysis of fetal sex and RhD gene in fetal cells DNA from maternal blood by polymerase chain reaction. Middle East fertility society Journal. Vol. 8, no 3. 263-268 17. Ahangari G, et al. (2004). Antibody production against E-coli polypeptide (ECP) by Dot blotting and ELIZA methods for ECP assay in recombinant drug and patients sera. Iranian Journal of Pediatrics. Vol. 13. 1. 18. Ahangari G. (2004). Natural antibiotic (antimicrobial peptides and clinical application). Modern technology in 3th millennium, Second edition, Book, ISBN: 964-7397-23-2, Publisher; Kholous, Tehran, Iran 19. Ahangari G, et al (2004). Growth hormone antibodies formation in patients treated with recombinant human growth hormone, International journal of Immunopathology and Pharmacology. Vol.17, 1. 20. Ahangari G, et al. (2004). Prenatal diagnosis of human fetal RhD blood group by heminested-PCR. Iranian Journal of Pediatrics. Vol. 14. 1. 21. Ahangari G, et al. (2004). The detection of dopamine gene receptors (DRD1DRD5) expression on human peripheral blood lymphocytes by Real-Time PCR. Iranian Journal of Allergy, Asthema and Immunology. Vol. 3. 4. 22. Rahimi Am, Shahoseini MH, Ahangari G, Shahsavar F, Seyed Rezaye Tehrani SM. (2004). Fetal Sex determination via nested-PCR method using Amylogenin, Yaft-E Journal, Vol6 no 22. 6 23. Ahangari G. (2006). Aptamer or DNA , RNA antibodies(clinical and diagnostic application). Modern technology in 3th millennium, Third edition, Book, ISBN: 964-7397-29-1, Publisher; Kholous, Tehran, Iran. 24. Ahangari G. et al (2006). Sequencing and expression of Elastase II gene in Polymorphoneuclear leukocytes in healthy individuals for determination of single nucleotide polymorphism (SNP) by RT-PCR. IJP, 16, 2: 201-109 25. Ahangari G, et al. (2006) RT-PCR based mutation detection of the inflammatory molecules Elastase II gene encoding neutrophil elastase in cyclic neutropenia patients by capillary sequencing. European Journal of Inflamation, 4, 1. 43-49 26. A. Hossein-Nejad, G. Ahangari, M. B. Larijani. (2006). Modulation of LBDLigand complex: Genetic variation of receptors. Proceeding Book of International Conference on Bio-Nanotechnology, 43-46 27. G.Ahangari, et al. (2007). Novel mutation detection of the inflammatory molecules Elastase II gene encoding neutrophil elastase in Kostmann syndrome by capillary sequencing. European Journal of Inflamation, 5,2. 6571 28. A. Farhoodi, Ahangari G, Chavoshzadeh Z, Ramyar A, Movahedi M, Ghareghozlou M, Fazlolahi M, Heyderzadeh M, Bemanian M H and F Zandieh, (2007), Relation between ELA2 gene mutatations, clinical and laboratory parameters in sever congenital and cyclic neutropenia.TUMJ, 65,7: 1-10 7 Conference Papers: 1. Oral Presentation, Ahangari G., et al. (1992). The studies of cell mediated immunity in Hodgkin’s lymphoma. Immunology Congress, Mashhad, IRAN. 2. Oral Presentation, Ahangari G., et al. (1993). Autologous bone marrow transplantation. The 5Th Congress of Pediatrics, Tehran, IRAN. 3. Poster Presentation, Ahangari G., et al. (1994).Determination of anti neutrophil cytoplasmic antibody (ANCA) in arthritis and generalised psoriasis. 4. Poster Presentation, Ahangari G., et al. (1994). Investigation of CD35 expression molecules on red blood cells in the Rheumatoid Arthritis patients. 5. Poster Presentation, Ahangari G., et al. (1994). Investigation of CD35 expression molecules on red blood cells in the Systemic Lupus Erythematosus patients.These abstract presented in Fourth BRETON workshop on Autoimmunity 14- 16 APRIL 1994, In BERITANE, FRANCE and published in special issue Clinical Experimental Rheumatology. 6. Poster presentation, Ahangari G., et al. (1995). The presence and clearance of immune complexes in the untreated generalised Psoriasis. The 9Th International Congress of Immunology, San Francisco, California, USA. 8 7. Oral Presentation, Ahangari G., et al. (1996). RT- PCR topography of chronic Psoriasis skin based on analysis of TCRBV gene usage. 27Th Scandinavian Society for Immunology Meeting, Turku, FINLAND. 8. Seminar, Ahangari G. (1997). Molecular aspect of skin immune system, Karolinska Institute, Microbiology and Tumor biology Center, Stockholm, SWEDEN. 9. Oral Presentation, Ahangari G., et al. (1996). RT-PCR based analysis of T-cell receptor BV region gene usage in normal human breast skin resident T lymphocytes (SRT), The FASEB Meeting, New Orleans, USA. 10. Oral Presentation, Ahangari G., et al. (1998). RT-PCR based analysis of T-cell receptor BV region gene usage in nickel allergic contact dermatitis. The 10Th International Congress of Immunology, New Delhi, INDIA. 11. Oral Presentation, Ahangari G., et al. (1998). Immunology of Psoriasis. The 4Th Iranian Congress of Immunology. Esfehan, IRAN. 12. Oral Presentation, Ahangari G., et al. (1998). The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. 4Th Iranian Congress of Biochemistry, Babol, IRAN. 13. Oral Presentation, Ahangari G., et al. (1999). Molecular aspect of skin Immune system. Annual Meeting of Iranian Dermatologist. Tehran, IRAN. 14. Oral Presentation, Ahangari G., et al. (1999). Application of gene rearrangement in clinical pathology. Annual meeting of Iranian Pathologist. Tehran, IRAN. 9 15. Oral Presentation, Ahangari G., et al. (1999). Application of Laser Flow cytometry on monitoring of Bioreactor. B.D. Center in Europe, Brussels, BELGIUM. 16. Oral Presentation, Ahangari G., et al. (2000). TCRVB gene usage bias in different parts of normal human skin based on RT-PCR analysis: Could it be evidence for peripheral T cell education? Second Asia and ocean Federation of Immunology, Bangkok, THAILAND. 17. Oral Presentation, Ahangari G.,et al. (2000), Non-invasive prenatal diagnosis of B-Thalassemia and sex, International Prenatal Diagnosis symposium, Tehran, IRAN. 18. Oral Presentation, Ahangari G., et al. (2000), New methods for Non-invasive Prenatal genetic Diagnosis (PGD). 11th Iranian Internal Medicine Congress, Tehran, IRAN. 19. Oral Presentation, Ahangari G., et al. (2000). Molecular diagnosis of RhD antigen by PCR. Annual Meeting of Iranian Pathologist. Tehran, IRAN. 20. Oral Presentation, Ahangari G., et al. (2000). New methods of prenatal diagnosis (Non-invasive) by PCR based on Fetal cell separation from maternal blood. Genetic congress, Ardabil , IRAN. 21. Oral Presentation, Ahangari G., et al. (2000). Non-invasive prenatal diagnosis of sex and thalassemia by PCR based on Fetal cell separation from maternal blood. First national medical genetic congress, Shahrakord , IRAN. 22. Oral Presentation, Ahangari G., et al. (2000). T cell receptor based on immunohistochemical analysis: could it be evidence for preferential usage of T cell receptor in Tonsil? XVII international congress of allergology and clinical immunology, Sydney, AUSTRALIA. 10 23. Oral Presentation, Ahangari G., et al. (2001). Application of tissue engineering in clinical diagnosis. Second Iranian Biotechnology congress, Karaj, IRAN. 24. Oral Presentation, Ahangari G., et al. (2001). Immunogenecity of recombinant human drug. 14th Pharmacology congress, Shiraz, IRAN. 25. Oral presentation, Ahangari G., et al. (2001). Could non-invasive prenatalgenetic diagnosis be evidence for prenatal X-linked Immunological disorders? 11th international congress of immunology, Stockholm, SWEDEN. 26. Poster presentation, Ahangari G. (2002). Efficiency of Dyna-beads methods for non-invasive prenatal genetic diagnosis using fetal cells. European Human Genetic Conference , Strasbourg, FRANCE. 27. Poster presentation, Ahangari G. (2003). RT-PCR based analysis of dopamine receptor gene expression on peripheral blood lymphocytes in schizophrenia patients. American school in forensic medicine and Mayo clinic course in advanced molecular medicine. Zagreb, Croatia. 28. Oral presentation, G. Ahangari, (2003), Immunological factors in spontaneous abortion. First annual meeting Iranian of Society of Fertility & Sterility. Tehran, Iran. 29. Oral presentation, G. Ahangari. (2004). Gender assignment. Second annual meeting Iranian of Society of fertility & Sterility. Tehran, Iran. 11 30. Oral presentation, G. Ahangari, (2004). Dopamine gene expression on human peripheral lymphocytes. 7th Iranian international congress of immunology. Mashhad, Iran. 31. Poster presentation. G. Ahangari, (2004), Molecular genetic analysis of HLA-A, B and DR alleles in recurrent spontaneous of immunology and 4th annual conference of FOCIS. Montreal, Canada. 32. Oral presentation, G. Ahangari, (2004), Multifactorial Genetic Disorders, International workshop on Application of advanced molecular methods for the diagnosis of human genetic diseases, (Under the auspices of ICGEB, Italy), September 2004, Tehran ,Iran 33. Oral presentation G. Ahangari.(2006). Application of Molecular Immunology in clinic and diagnostic, International Immunology Congress, Tehran, Iran 34. Seminar Presentation , G. Ahangari. (2006). Skin Tissue Engineering, Koro Institute, Shefiled, UK 35. Oral presentation, G Ahangari, (2006). Tissue Engineering and Clinical application. First Iranian Theoretical and Practical Workshop. Tehran, Iran 36. Poster presentation, A. Hossein-Nejad, G. Ahangari, M. B. Larijani, (2007). Osteoimmunological regulation by genetic variations of vitamin D receptor. Immunorio, Rio de Janeiro, Brazil. 37. G. Ahangari and Naderimanesh H, (2007), Effectiveness of pooled autoantibody array in clinical diagnostic autoimmune disease by using tissue engineering technology. Journal of Tissue engineering, 13,17: 1681 12 38. A. Hossein-Nejad, G. Ahangari, Maghboli Z and et al. (2007). Vitamine D receptor gene variations modifie cytokines effects on bone turn over. Journal of Bone . 40 (6): 243 39. A. Hossein-Nejad, G. Ahangari, Maghboli Z and et al. (2007). The role of Vitamine D receptor gene variations an dits interaction with immune regulatory molecules in bone turn over. Journal of Calcified Tissue International, 80:99 Membership: American Association of Immunologists. Federation American Society for Experimental Biology. Scandinavian Society for Immunology. Iranian Biotechnology Society International Tissue engineering Society, EU Section Editorial Board Members: Open Journal of pathology 13