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A New Method for Creating Transgenic Animals INVENTORS • Robert Bremel, Anthony W. S. Chan, Jane Burns WARF: P95253US View U.S. Patent No. 6,080,912 in PDF format. Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin- The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing improved methods for the production of transgenic animals. Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They OVERVIEW are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have The ability to alter the genetic makeup of animals such as cows, pigs and sheep allows a number of commercial applications. These applications include the production of animals that express large quantities of exogenous proteins in their milk, are resistant to infection or have enhanced growth rates. negotiated innovative licensing strategies to meet the individual needs of business clients. The most widely used method for the production of transgenic animals is microinjection of DNA into the pronuclei of fertilized embryos. However, while this method works well for the production of transgenic mice, it is much less efficient for the production of transgenic livestock. THE INVENTION UW–Madison researchers have developed improved methods and compositions for the generation of transgenic non-human animals. The methods permit the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., prematuration oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. They increase the efficiency of producing transgenic animals while reducing the rate of generating animals that are mosaic for the presence of the transgene. APPLICATIONS • Production of transgenic animals, particularly cows KEY BENEFITS • Increased efficiency Wisconsin Alumni Research Foundation | 614 Walnut Street, 13th Floor | Madison, WI 53726 | [email protected] | www.warf.org WARF: P95253US • Reduced generation of mosaic animals ADDITIONAL INFORMATION Tech Fields Agriculture - Animal biotech CONTACT INFORMATION For current licensing status, please contact Emily Bauer at [email protected] or (608) 262-8638. Wisconsin Alumni Research Foundation | 614 Walnut Street, 13th Floor | Madison, WI 53726 | [email protected] | www.warf.org