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High-Intensity Signal on Time-of-Flight Magnetic Resonance Angiography Indicates Carotid Plaques at High Risk for Cerebral Embolism During Stenting by Shinichi Yoshimura, Kiyofumi Yamada, Masanori Kawasaki, Takahiko Asano, Masayuki Kanematsu, Manabu Takamatsu, Akira Hara, and Toru Iwama Stroke Volume 42(11):3132-3137 October 24, 2011 Copyright © American Heart Association, Inc. All rights reserved. A representative case with high-intensity signal (HIS)-positive plaque on maximum intensity projection (MIP) images of time-of-flight (TOF) MRA. Images were obtained from a 61-year-old man who had asymptomatic severe carotid artery stenosis. Shinichi Yoshimura et al. Stroke. 2011;42:3132-3137 Copyright © American Heart Association, Inc. All rights reserved. A representative case with high-intensity signal (HIS)-negative plaque on maximum intensity projection (MIP) images of time-of-flight (TOF) MRA. Images were obtained from a 58-year-old man who had asymptomatic severe carotid artery stenosis. Shinichi Yoshimura et al. Stroke. 2011;42:3132-3137 Copyright © American Heart Association, Inc. All rights reserved. The relationship between high-intensity signal (HIS) on time-of-flight (TOF) MRA and the glycophorin A-positive area (%; A), number of CD68-positive cells (B), and fibrous cap thickness (C) of plaques obtained by endarterectomy. Shinichi Yoshimura et al. Stroke. 2011;42:3132-3137 Copyright © American Heart Association, Inc. All rights reserved. The relationship between the presence of high-intensity signal (HIS) in the plaque on time-offlight (TOF) MRA and new ischemic lesions on diffusion weighted imaging (DWI; A) and periprocedural ischemic symptoms (B). Shinichi Yoshimura et al. Stroke. 2011;42:3132-3137 Copyright © American Heart Association, Inc. All rights reserved.