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Tad Holak Chemical Biology and Drug Discovery for Oncology Indications Organic Chemistry, Jagiellonian University, Kraków, Poland Malopolskie Center for Biotechnology UJ, Kraków, Poland Organic compounds X-ray structures Cell activity X-ray structure of the protein-protein complex synthesis X-ray structures: compoundprotein Check by NMR if the compound dissociates the protein-protein complex Small-molecule compounds for targeting protein-protein interactions for nongenotoxic therapy of cancer N N N N S CO2Me NH N N Cl NH O Cl N H Cl Cl PB1 PB3 PB2 Cl O Cl O N O N H NH N N N N Cl PB5 PB4 O O S N HN N Cl Cl PB6 H N Cl N H NH OH PB8 PB7 PB9 Cl H N S HO2C NH2 N N Cl N H Cl NH O CO2Et Cl PB10 PB12 N Cl Releasing p53 from its MDM2 inhibition – to carry out its anti-tumor duties in tumor cells 50% antagonist 50% Collaborations Molecular biology Jacek Otlewski Wrocław Organic chemistry Alexander Dömling Groningen NL Grzegorz Dubin Kraków NMR T. Holak Kraków Current group members The group Postdocs: Dr. Bogdan Musielak Dr. Łukasz Skalniak Dr. Bartek Zięba Dr. Ewa Wrona PhD students: Marcin Tomala Radosław Kitel Katarzyna Guzik Marcin Pustuła Sylwia Krzanik Katarzyna Kubica Mirosława Czub Dobrosława Krzemień Katarzyna Magiera Aleksandra Twarda Krzysztof Żak MSc students: Paulina Topór Beata Łabuzek Dominik Sala Oliwia Matuszewska Damian Muszak Diana Karwicka Justyna Polak Justyna Kocik Katarzyna Sitarz
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