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Mechanism of peptide hydrolysis by cysteine cathepsins. An acylation reaction between free cathepsin (upper left-hand side) with its Cys-His dipole and
the target protein at the sessile bond results in an unstable tetrahedral intermediate (upper right-hand side) with subsequent release of the C-terminal
peptide from the target protein, leaving an acyl-enzyme. A subsequent deacylation reaction results in the release of the N-terminal peptide of the target
protein and restoration of free cathepsin.
Source: Pycnodysostosis: Cathepsin K Deficiency, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular
Bases of Inherited Disease; 2014 Available at: http://mhmedical.com/ Accessed: August 03, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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