Download NCD 11-203 - Identification and Quantification of Proteins

Identification and Quantification of
Proteins in Tissue and Cell Preparation
USC Case #11-203
Market Opportunity:
With the increased understanding of underlying disease
mechanisms and disease pathology, and a growing need for new
drug targets, proteomics have gained increased prominence as
a research tool. Proteomics offer a direct look at the biological
function of the cell or organism; however, the current methods of
analysis of the protein mixture are limited by their reproducibility,
sensitivity, and throughput.
Applications
USC Solution:
Stage of Development
The current USC invention overcomes the state-of-the-art
drawback of protein quantification in a mixture by labeling and
counting component antigens in tissue and other cell
preparations. The invention makes use of a novel antibodybased approach for the capture of protein of interest and
quantifying it by use of specific probes.
• Protein identification and
quantification
• Target validation (ascertaining
an investigational drug as
desired effect)
• Tested
• Available for non-exclusive
research license
Technology Value
Intellectual Property
Status:
Value Proposition
Patent application published,
13/877,436
• Overcomes the bias in the current state-of-the-art
quantification process towards proteins of high abundance
• Method provides for high sensitivity and reproducibility
Keywords:
Proteomics, identification, quantification, tissue, cell mixture
Contact Information
Bonnie Wolfe
Licensing Associate, Life Sciences
(213) 821-0938
[email protected]
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