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Table 1 Chimpanzee cancer gene products identical to human orthologs Name B-cell CLL/lymphoma 10 damage-specific DNA binding protein 2 MAD2 mitotic arrest deficient-like 1 RAD51-like 1 RAD9 homolog A GNAS complex locus v-Ha-ras Harvey rat sarcoma viral oncogene homolog v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog neuroblastoma RAS viral oncogene homolog septin 5 septin 6 chimerin 1 Wiskott-Aldrich syndrome cyclin-dependent kinase 2 pim-1 oncogene protein kinase, cAMP-dependent, regulatory, type I, alpha cyclin-dependent kinase inhibitor 1B cyclin-dependent kinase inhibitor 2A succinate dehydrogenase complex, subunit C nascent-polypeptide-associated complex alpha phosphatase and tensin homolog protein tyrosine phosphatase, non-receptor type 11 FIP1 like 1 cylindromatosis ribosomal protein L22 clathrin, heavy polypeptide RAB6 interacting protein 2 growth arrest-specific 7 LIM and SH3 protein 1 lymphocyte cytosolic protein 1 LIM domain containing preferred translocation partner moesin nucleophosmin tropomyosin 4 Symbol RefSeq Locus BCL10 DDB2 MAD2L1 RAD51L1 RAD9A GNAS HRAS KRAS2 NRAS SEPT5 SEPT6 CHN1 WAS CDK2 PIM1 PRKAR1A CDKN1B CDKN2A -p16INK4A SDHC NACA PTEN PTPN11 FIP1L1 CYLD RPL22 CLTC ELKS GAS7 LASP1 LCP1 LPP MSN NPM1 TPM4 NM_003921 NM_000107 NM_002358 NM_002877 NM_004584 NM_000516 NM_176795 NM_004985 NM_002524 NM_002688 NM_015129 NM_001822 NM_000377 NM_001798 NM_002648 NM_002734 NM_004064 NM_000077 NM_003001 NM_005594 NM_000314 NM_002834 NM_030917 NM_015247 NM_000983 NM_004859 NM_015064 NM_003644 NM_006148 NM_002298 NM_005578 NM_002444 NM_002520 NM_003290 1p22 11p12 4q27 14q23 11q13 20q13 11p15 12p12 1p13 22q11 Xq24 2q31 Xp11 12q13 6p21 17q23 12p13 9p21 1q21 12q23 10q23 12q24 4q12 16q12 3q26 17q11 12p13 17p13 17q11 13q14 3q28 Xq11 5q35 19p13 Lenght (aa) Category 233 427 205 350 391 394 170 188 189 369 434 459 502 298 313 381 198 156 169 215 402 593 594 956 128 1675 948 336 261 627 612 577 294 248 Apoptosis DNA repair DNA repair DNA repair DNA repair GTPase GTPase GTPase GTPase GTPase GTPase GTPase activator GTPase regulator Kinase Kinase Kinase Kinase Inhibitor Kinase Inhibitor Metabolism Nascent polypeptide associated complex Phosphatase Phosphatase Polyadenylation Protease Ribosome Structural Structural Structural Structural Structural Structural Structural Structural Structural ZW10 homolog topoisomerase I paired related homeobox 1 B-cell CLL/lymphoma 11A runt-related transcription factor 1 v-ets erythroblastosis virus E26 oncogene like Friend leukemia virus integration 1 GATA binding protein 1 hepatic leukemia factor high mobility group AT-hook 2 homeo box A11 homeo box A13 homeo box C13 hyperparathyroidism 2 LIM domain only 1 mothers against DPP homolog 4 nuclear receptor coactivator 2 paired box gene 5 pre-B-cell leukemia transcription factor 1 retinoic acid receptor, alpha T-cell acute lymphocytic leukemia 2 T-cell leukemia, homeobox 3 Ikaros tripartite motif-containing 24 SMARC, subfamily b, member 1 suppressor of fused homolog F-box and WD-40 domain protein 7 von Hippel-Lindau tumor suppressor mixed-lineage leukemia translocated to, 11 bromodomain containing 4 B-cell translocation gene 1 cysteine-rich hydrophobic domain 2 papillary renal cell carcinoma PRO1073 protein Shwachman-Bodian-Diamond syndrome TRK-fused gene TCF3 (E2A) fusion partner ZW10 TOP1 PMX1 BCL11A CBFA2T1 ERG FLI1 GATA1 HLF HMGA2 HOXA11 HOXA13 HOXC13 HRPT2 LMO1 MADH4 NCOA2 PAX5 PBX1 RARA TAL2 TLX3 ZNFN1A1 TIF1 SMARCB1 SUFU FBXW7 VHL AF1Q BRD4 BTG1 CHIC2 PRCC PRO1073 SBDS TFG TFPT NM_004724 NM_003286 NM_006902 NM_018014 NM_004349 NM_004449 NM_002017 NM_002049 NM_002126 NM_003483 NM_005523 NM_000522 NM_017410 NM_024529 NM_002315 NM_005359 NM_006540 NM_016734 NM_002585 NM_000964 NM_005421 NM_021025 NM_006060 NM_003852 NM_003073 NM_016169 NM_018315 NM_000551 NM_006818 NM_014299 NM_001731 NM_012110 NM_005973 AF113016 NM_016038 NM_006070 NM_013342 11q23 20q12 1q24 2p13 8q22 21q22 11q24 Xp11 17q22 12q15 7p15 7p15 12q13 1q21 11p15 18q21 8q13 9p13 1q23 17q12 9q31 5q35 7p12 7q32 22q11 10q24 4q31 3p25 1q21 19p13 12q22 4q11 1q21 11q31 7q11 3q11 19q13 779 765 217 773 577 462 452 413 295 109 313 388 330 531 156 552 1464 391 430 462 108 291 519 1016 385 484 627 213 90 722 171 165 491 57 250 400 253 Structural Topoisomerase Transcription co-activator Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription Factor Transcription regulation Tumor suppressor Tumor suppressor Ubiquitylation Ubiquitylation Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown
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