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CD4+CD25+ regulatory T-cell lines from human cord blood
have functional and molecular properties of T-cell anergy
by Lequn Li, Wayne R. Godfrey, Stephen B. Porter, Ying Ge, Carle H. June, Bruce R.
Blazar, and Vassiliki A. Boussiotis
Blood
Volume 106(9):3068-3073
November 1, 2005
©2005 by American Society of Hematology
Treg cell lines generated from cord blood exhibit impaired proliferation and IL-2 production in
response to stimulation by TCR and costimulation.
Lequn Li et al. Blood 2005;106:3068-3073
©2005 by American Society of Hematology
Distinct TCR–CD3/CD28 signaling in Treg cell lines.
Lequn Li et al. Blood 2005;106:3068-3073
©2005 by American Society of Hematology
Cell cycle progression in response to TCR–CD3/CD28 is blocked in Treg cell lines and can be
rescued by exogenous IL-2.
Lequn Li et al. Blood 2005;106:3068-3073
©2005 by American Society of Hematology
IL-2/IL-2 receptor signaling prevents Tregs from undergoing activationinduced cell death.
Lequn Li et al. Blood 2005;106:3068-3073
©2005 by American Society of Hematology
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