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Monovalent Fc receptor blockade by an anti–Fcγ
receptor/albumin fusion protein ameliorates murine ITP
with abrogated toxicity
by Xiaojie Yu, Melissa Menard, József Prechl, Varsha Bhakta, William P. Sheffield,
and Alan H. Lazarus
Blood
Volume 127(1):132-138
January 7, 2016
©2016 by American Society of Hematology
In vitro binding activity of 3G8 scFv-HSA for huFcγRIIIA.
Xiaojie Yu et al. Blood 2016;127:132-138
©2016 by American Society of Hematology
In vitro binding activity of 2.4G2 scFv-MSA for murine FcγRIII/IIB and in vivo pharmacokinetics.
Xiaojie Yu et al. Blood 2016;127:132-138
©2016 by American Society of Hematology
In vivo efficacy of 2.4G2 scFv-MSA in ITP amelioration.
Xiaojie Yu et al. Blood 2016;127:132-138
©2016 by American Society of Hematology
Changes in body temperature induced by antibody 2.4G2 and 2.4G2 scFv-MSA.
Xiaojie Yu et al. Blood 2016;127:132-138
©2016 by American Society of Hematology
Basophil activation induced by antibody 2.4G2 and 2.4G2 scFv-MSA.
Xiaojie Yu et al. Blood 2016;127:132-138
©2016 by American Society of Hematology
Transient basophil depletion induced by antibody 2.4G2 and 2.4G2 scFv-MSA.
Xiaojie Yu et al. Blood 2016;127:132-138
©2016 by American Society of Hematology
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