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Massively parallel sequencing: the new frontier of
hematologic genomics
by Jill M. Johnsen, Deborah A. Nickerson, and Alex P. Reiner
Blood
Volume 122(19):3268-3275
November 7, 2013
©2013 by American Society of Hematology
Types of DNA sequence variation.
Jill M. Johnsen et al. Blood 2013;122:3268-3275
©2013 by American Society of Hematology
First-generation sequencing and genome-wide association technologies.
Jill M. Johnsen et al. Blood 2013;122:3268-3275
©2013 by American Society of Hematology
Schematic of 1 form of NGS. The process starts by randomly cutting genomic DNA (or cDNA)
into short fragments (a few hundred base pairs in length).
Jill M. Johnsen et al. Blood 2013;122:3268-3275
©2013 by American Society of Hematology
Screenshot from exome variant server of the MPL gene showing part of a summary table of
variants discovered through the NHLBI ESP. The current data release is taken from 6503
unrelated European American and African American samples drawn from multiple ESP c...
Jill M. Johnsen et al. Blood 2013;122:3268-3275
©2013 by American Society of Hematology
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