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Massively parallel sequencing: the new frontier of hematologic genomics by Jill M. Johnsen, Deborah A. Nickerson, and Alex P. Reiner Blood Volume 122(19):3268-3275 November 7, 2013 ©2013 by American Society of Hematology Types of DNA sequence variation. Jill M. Johnsen et al. Blood 2013;122:3268-3275 ©2013 by American Society of Hematology First-generation sequencing and genome-wide association technologies. Jill M. Johnsen et al. Blood 2013;122:3268-3275 ©2013 by American Society of Hematology Schematic of 1 form of NGS. The process starts by randomly cutting genomic DNA (or cDNA) into short fragments (a few hundred base pairs in length). Jill M. Johnsen et al. Blood 2013;122:3268-3275 ©2013 by American Society of Hematology Screenshot from exome variant server of the MPL gene showing part of a summary table of variants discovered through the NHLBI ESP. The current data release is taken from 6503 unrelated European American and African American samples drawn from multiple ESP c... Jill M. Johnsen et al. Blood 2013;122:3268-3275 ©2013 by American Society of Hematology